Application Notes

As the cost of helium increases and its availability decreases, an increasing number of Gas Chromatography (GC) professionals are considering switching to hydrogen gas for their carrier gas.

The ability to simultaneously collect quantitative and qualitative information from a DMPK analysis has the potential to significantly increase productivity in pharmaceutical drug discovery and development.

Heparin is a polydisperse, heterogeneous polysaccharide derived from animal tissue. Heparin has been used as an anticoagulant for over 60 years and one of the fundamental parameters for characterizing unfractionated heparin (UFH) is its molecular weight (MW) and MW distribution.

The use of UHPLC systems for small molecule analysis has gained widespread acceptance among researchers in recent years.

Fusel alcohols, a common byproduct of fermentation, in abnormal quantities or types can indicate alcoholic beverage adulteration.

US EPA method 529 is the procedure to determine explosives and related compounds in finished drinking water.

In mass spectrometry instrumentation, the sensitivity and resolution of the instrument is often limited by the detector.

Chromium (Cr) is a metal with an interesting relationship to the environment. Whereas trivalent chromium (Cr(III)) is an essential nutrient, hexavalent chromium (Cr(VI)) is a poison to humans and aquatic life and poses serious environmental and ecological threats.

Analysis of polycarbonate urethanes (PCUs) are a class of biocompatible polyurethanes that show great promise for use in orthopedic implants, such as artificial hips.

Ultra high performance liquid chromatography (UHPLC) continues to grow in popularity due to highly efficient columns and fast run times, which result in excellent resolution and high throughput.

Monoamine neurotransmitters (adrenaline, dopamine, noradrenaline, and acetylcholine) are released from the brain and peripheral nervous system in minute amounts.

EPA 8270D calls for the extraction for analysis of semi-volatile analytes in various matrices. Target analytes mentioned in the method cover a wide range of compound classes resulting in reporting lists that often approach 100 compounds.

Laboratories taking in a high volume of aqueous semi-volatile samples know that every sample is different.

In the USP method for acetaminophen (1), the related compound p-aminophenol is determined using spectrophotometry while another related compound, p-chloroacetanilide, is determined using TLC.

Polymer Char

Agilent Technologies

Shimadzu Europa GmbH

Over the last decade the use of pharmaceuticals and personal care products (PPCPs) has doubled in the United States.

Degradation studies of biotherapeutic proteins are necessary to test their stability. The best way to test the suitability of a method is the use of real-time stability samples containing all relevant degradation products that might occur over time.

US EPA Method 528 determines 12 phenols in finished drinking water using solid phase extraction (SPE) and GC–MS detection.

The peptide and protein based pharmaceuticals are a rapidly expanding class of therapeutical agents that are used to treat a wide variety of health conditions, including cancer, metabolic and auto-immune diseases, HIV, and more.

Chiral chromatography has a wide range of applications in the food, biochemical, and pharmaceutical industries.

The analysis of the amorphous fraction is a fundamental task in the production of polypropylene.

Peptide mapping by reversed-phase chromatography is the mainstay technique in biotherapeutic analysis, delivering the comprehensive characterization of biopharmaceutical products.

Amino acids, dipeptides, and their related compounds are analyzed in a wide variety of industries.

The presence of polymerized triacylglycerides or chlorophyll degradation products in olive oil indicates that the oil has been refined or subject to other thermal treatment processes.

Isocyanates are highly reactive, low molecular weight chemicals. They are widely used in the manufacture of flexible and rigid foams, fibers, coatings such as paints and varnishes, and elastomers.

Columns packed with fully porous particles have long been considered "normal science" for HPLC practitioners. Since 2006, Fused-Core? or core-shell columns have caused a paradigm shift in the minds of liquid chromatographers who analyze small molecules (1).

Two important but frequently underutilized tools in methods development are mobile phase pH and elevated temperatures.

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