Gas Chromatography (GC)

This pyrolysis–GC–MS method enables direct analysis of solid or liquid polymers without sample pretreatment, as illustrated here for various materials, including a dental filling material and a car wrapping foil.

Despite the advantages of soft ionization ion-source technologies for improving confidence in the identification of a range of challenging analytes, soft ionization remains a niche technique for gas chromatography–mass spectrometry (GC–MS).

A discussion on the safe storage and use of calibration, carrier, and detector gas cylinders for small or large organizations.

Key considerations for setting up or troubleshooting a GC method.

A series of real life problems submitted by CHROMacademy members are used to highlight common problems with separations and instruments.

Pulsed-flow-modulated comprehensive two-dimensional gas chromatography with flame ionisation detection was used to separate and identify all common sulphur compounds found in natural gas.

We track the genesis of the top four carrier gases before they start their journey through a GC system.

When the goal is to improve the effectiveness of GC method development, a little help can go a long way. In the latest installment of The LCGC Blog, Tony Taylor offers expert advice on GC temperature program development, highlighting the thinking behind establishing the major parameters with the GC temperature program.

Click here to view the complete E-Separation Solutions newsletter from December 5, 2013.

In this article, the sensitivity of two-dimensional gas chromatography coupled to two different detectors - a time-offl ight mass spectrometer (GCXGC–TOF-MS) and a fl ame ionization detector (GC?GC–FID) - was compared to the sensitivity of conventional one-dimensional gas chromatography (GC–TOF-MS and GC–FID) by determining method detection limits (MDLs) for a series of different compounds with different polarities.

Click here to view the complete E-Separation Solutions newsletter from November 26, 2013.

Incognito lectures on the importance of knowing the fundamentals of your GC methods.

This article presents GC–GC(qMSMS) data on the analysis and quantitation of polychlorinated biphenyls (PCBs) in a complex matrix (fly ash). Calibration curves were recorded between 0.1 pg and 100 pg.

Click here to view the complete E-Separation Solutions newsletter from November 21, 2013.

Diesel exhaust fumes can rapidly degrade the floral odours used by honeybees (Apis melifera) to identify flowering plants, according to results published by scientists at the University of Southampton (Southampton, UK) in the journal Scientific Reports.1

A discussion of the effects of increased carrier-gas flow in an example separation that includes two pairs of solutes.

An interview with Hans-Gerd Janssen of Unilever Research and Development Vlaardingen and the University of Amsterdam. Janssen is involved with method development for gas chromatography, liquid chromatography, and mass spectrometry; the development of instrumentation for multidimensional chromatography for food analysis and biomacromolecular characterization; and problem solving and efficient routine analysis of foods (particularly oils and fats). This interview discusses the challenges encountered in the analysis of fats and oils, how multidimensional chromatography can be applied to the analysis, 2D LC for food-related compound analysis, the analysis of natural antioxidants in edible oils, and future steps in his research.

The anatomy of chromatographic peaks is examined with attention to features that help determine the suitability of individual chromatographs for a specific analysis task.

Gas chromatography with electron ionization and mass spectrometry (GC–EI-MS) detection is a workhorse among analytical techniques in metabolomics. A major challenge in the utilization of GC–EI-MS in metabolomics is the identification of unknowns.

Click here to view the complete E-Separation Solutions newsletter from September 19, 2013.

Tony Taylor provides insight on the best way to choose GC columns based on analyte or sample characteristics.

Click here to view the complete E-Separation Solutions newsletter from September 5, 2013.

This article provides an update on the search for an alternative to helium.

This article discusses how a dedicated air sampling system with TD–GC–FID can allow more frequent sampling of air pollutants.

Market Profile: GC–MS

Recently LCGC asked a panel of experts (listed in the sidebar) to assess the current state of the art of gas chromatography (GC) instrumentation and methods and to try to predict how the technology will develop in the future.

Understanding the chemistry behind GC separations can lead to faster problem identification and improved troubleshooting.

A practical and reliable analytical procedure that incorporates MDGC with a planar microfl uidic device as a Deans switch was developed for the characterization of chlorinated degreasers in marine gas oil.

Understanding the chemistry behind GC separations can lead to faster problem identifi cation and improved troubleshooting.

Long-distance running is examined as a metaphor for gas chromatography separations.