Gas Chromatography (GC)

Can databases of column characteristics be used to help with HPLC column selection ahead of method development?

In this instalment John V. Hinshaw reviews gas chromatography instruments and accessories that were newly presented at Pittcon 2012 or were introduced to the marketplace in the preceding year.

On-line heart-cut LC–GC and, more recently, comprehensive LC–GC (LC?GC) are very powerful analytical techniques because of the combination of the selectivity features of LC with the high efficiency of GC. This article presents an overview of the most recently used interfacing systems, as well as applications in the food analysis.

A review of gas chromatography instruments and accessories presented at Pittcon 2012

An effective analytical method for detecting pesticide residues in olive oil

The resolution, sensitivity, and mass accuracy of the Agilent 7200 GC/Q-TOF system provide rapid, simple, and reliable analysis of trace levels of sulfur compounds in coffee.

The automated derivatization of fatty acids (FAs) was performed with the Agilent 7696A Sample Prep WorkBench. Since free fatty acids show tailing in gas chromatography, transformation of fatty acids into fatty acid methyl esters (FAMEs) is widely used.

Hyphenated approaches to analysis have received much attention over the last three decades to the extent that techniques such as GC?MS, GC?FTIR and LC?MS have ? in the relevant fields ? become indispensable parts of the analyst?s arsenal. This concept has been extended to include multi-hyphenated techniques, where the chromatography is preceded by analyte extraction from a sample matrix. In the field of GC?MS, examples include thermal, sorptive or headspace extraction, with subsequent preconcentration, for instance, by thermal desorption (TD).

Here is what to do to bring an idle capillary GC inlet column and detector back to operating condition – including column installation, electronic pneumatic control calibration, system bakeout and basic test mix performance.

Here is what to do to bring an idle capillary GC inlet column and detector back to operating condition – including column installation, electronic pneumatic control calibration, system bakeout and basic test mix performance.

The article discusses the fundamentals of instrumentation for headspace sampling, including vial thermostating, pressurization and transfer to the GC inlet.

This article looks at selectivity throughout the whole sample analysis cycle from the sampling stage, through sample preparation, sample introduction, analyte separation, analyte detection, data analysis and report generation.

Gas chromatography?mass spectrometry (GC?MS) combines a gas chromatographic front-end separation with a mass spectrometer. For the most part, the gas chromatographs and mass spectrometers used are modular in design and relatively easily separable. GC?MS is the most widespread tandem technique in the analytical instrumentation industry, which are employed across many different industries, particularly for environmental, chemical and toxicological applications.

How to use fluidic switching devices for open-tubular column manipulations, such as heartcutting and comprehensive multidimensional GCxGC.

Describes an analysis that was performed in a forensic science laboratory to assess who was the victim and who was the attacker in a legal dispute.

In recent years, recognition of multidimensional chromatographic technologies such as classical heart-cut MDGC, comprehensive GC×GC(MS), comprehensive LC×LC and LC×GC(MS) has increased because of their easy handling and software control. This article focuses on heart?cut MDGC and comprehensive GC×GC(qMS) using fast scanning quadrupole mass analysers.

Addresses some of the details of static HSGC theory and practice for conventional liquid-phase headspace samples to better understand and control the analytical processes.

Describing an accurate analytical technique for the detection and quantification of water using IL-based capillary GC.

In this article we look at the determination of phthalate esters in childcare products and children's toys by GC-MS.

Discussion about the use of gas switching valves for column backflush and two-dimensional series bypass applications.

This article discusses some of the technical considerations and practical aspects of UFGC as a method and considers several key applications of its use.

Janet Kelsey speaks to Alun Cole, director of ALMSCO International, to find out more about GC-MS and the potential it offers for high-definition screening.

SFC–GCxGC is shown to be useful in fossil fuel analysis. Practical examples for the analysis of complex matrices are described.

The 2nd part of this series discusses the use of gas switching valves for column backflushing and 2D series-bypass applications.

The advantages of using software to optimize GC methods with practical examples for pesticide analysis are described.

Laboratories all around the world stand or fall by their reputation for accuracy and quality control.

This article describes the current requirements for the analysis of POPs and the measures taken to improve workflows, enabling high throughput and low complexity screening using GC-MS-MS.

A simultaneous headspace-GC–FID method was validated to establish methanol and ethanol assessment in blood, urine and saliva.

The Open University and Agilent Technologies UK have announced the launch of the Agilent Centre of Excellence in Comprehensive Chromatography.

Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.