Gas Chromatography (GC)

A number of frequently asked questions about gases and their delivery to a gas chromatography instrument are addressed.

In this month's instament, John Hinshaw addresses a number of frequently asked questions about gases and their delivery to a gas chromatography instrument.

SPME decouples sampling from matrix effects that would distort the apparent sample composition or disturb the chromatographic separation. It is also easy to use and reduces solvent consumption.

Following the publication of “Analysis of the State of the Art: GC Instrumentation†in the August 2012 issue of LCGC, a reader notes further factors to consider, including poor user training, unanswered questions in fast GC, and the need for further instrument improvements, particularly better deactivation of the internal surfaces to minimize loss of trace samples.

Achieving efficient analyte transfer between columns is critical to gaining the benefits of multidimensional GC.

Comprehensive GCÃ-GC(qMS) provides a maximum chromatographic separation power in gas chromatography (GC). Combining it with the highly selective negative chemical ionization (NCI) mode gives highest sensitivity for electrophilic molecules like trichloroanisole and tribromoanisole.

This article describes the GC–MS and LC–MS screening methods developed by the Environment Agency for England and Wales for the analysis of both low-volumn water samples and extracts obtained from various designs of passive samplers.

In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) to assess the current state of the art of gas chromatography (GC) instrumentation and to try to predict how the technology will develop in the future.

In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts to assess the current state of the art of gas chromatography (GC) column technology, and to try to predict how the technology will develop in the future.

This month's instalment presents the latest tools and accessories for the gas chromatographer. Have you got what you need in your troubleshooting toolkit?

In this instalment John V. Hinshaw reviews gas chromatography instruments and accessories that were newly presented at Pittcon 2012 or were introduced to the marketplace in the preceding year.

Comprehensive GC×GC(MS) and LC×LC(MS) are chromatographic hyphenation methods providing the users with extremely large peak capacities.

An overview of important GC–MS techniques currently used in food analysis is described. Considerable attention is devoted to the use of the mass spectrometer, in relation to its poptential for separation and identification. The importance of comprehensive GC?GC is also discussed.

Can databases of column characteristics be used to help with HPLC column selection ahead of method development?

In this instalment John V. Hinshaw reviews gas chromatography instruments and accessories that were newly presented at Pittcon 2012 or were introduced to the marketplace in the preceding year.

On-line heart-cut LC–GC and, more recently, comprehensive LC–GC (LC?GC) are very powerful analytical techniques because of the combination of the selectivity features of LC with the high efficiency of GC. This article presents an overview of the most recently used interfacing systems, as well as applications in the food analysis.

A review of gas chromatography instruments and accessories presented at Pittcon 2012

An effective analytical method for detecting pesticide residues in olive oil

The resolution, sensitivity, and mass accuracy of the Agilent 7200 GC/Q-TOF system provide rapid, simple, and reliable analysis of trace levels of sulfur compounds in coffee.

The automated derivatization of fatty acids (FAs) was performed with the Agilent 7696A Sample Prep WorkBench. Since free fatty acids show tailing in gas chromatography, transformation of fatty acids into fatty acid methyl esters (FAMEs) is widely used.

Hyphenated approaches to analysis have received much attention over the last three decades to the extent that techniques such as GC?MS, GC?FTIR and LC?MS have ? in the relevant fields ? become indispensable parts of the analyst?s arsenal. This concept has been extended to include multi-hyphenated techniques, where the chromatography is preceded by analyte extraction from a sample matrix. In the field of GC?MS, examples include thermal, sorptive or headspace extraction, with subsequent preconcentration, for instance, by thermal desorption (TD).

Here is what to do to bring an idle capillary GC inlet column and detector back to operating condition – including column installation, electronic pneumatic control calibration, system bakeout and basic test mix performance.

Here is what to do to bring an idle capillary GC inlet column and detector back to operating condition – including column installation, electronic pneumatic control calibration, system bakeout and basic test mix performance.

The article discusses the fundamentals of instrumentation for headspace sampling, including vial thermostating, pressurization and transfer to the GC inlet.

This article looks at selectivity throughout the whole sample analysis cycle from the sampling stage, through sample preparation, sample introduction, analyte separation, analyte detection, data analysis and report generation.

Gas chromatography?mass spectrometry (GC?MS) combines a gas chromatographic front-end separation with a mass spectrometer. For the most part, the gas chromatographs and mass spectrometers used are modular in design and relatively easily separable. GC?MS is the most widespread tandem technique in the analytical instrumentation industry, which are employed across many different industries, particularly for environmental, chemical and toxicological applications.

How to use fluidic switching devices for open-tubular column manipulations, such as heartcutting and comprehensive multidimensional GCxGC.

Describes an analysis that was performed in a forensic science laboratory to assess who was the victim and who was the attacker in a legal dispute.

In recent years, recognition of multidimensional chromatographic technologies such as classical heart-cut MDGC, comprehensive GC×GC(MS), comprehensive LC×LC and LC×GC(MS) has increased because of their easy handling and software control. This article focuses on heart?cut MDGC and comprehensive GC×GC(qMS) using fast scanning quadrupole mass analysers.

Addresses some of the details of static HSGC theory and practice for conventional liquid-phase headspace samples to better understand and control the analytical processes.