Distribution agreement for laboratory chemicals
May 10th 2010Covidien has announced that its Mallinckrodt Baker business unit has entered into a multi-year agreement with global laboratory supply company, VWR International to distribute Mallinckrodt Baker?s J.T.Baker brand products in Eastern and Central Europe.
Biomarker research collaboration
May 5th 2010Thermo Fisher Scientific and Professor Bruno Domon, director of the new Luxembourg Clinical Proteomics unit (LCP), have announced a collaboration to develop workflows to overcome current bottlenecks in biomarker discovery and assay development for clinical proteomics research.
Branching Out: Mass Spectrometry and the Shape of Biotherapeutics
May 1st 2010Those fond of puns point out that mass spectrometry (MS) has become ever more focused in the last two decades, while at the same time offering ever more information. The dynamic market for biotherapeutics has driven a number of developments, particularly following the paradigm of well-characterized biopharmaceutical products (WCBP) (1,2). Partly as a result of automation and interfacing, those trained in biological or biochemical disciplines now use mass spectrometers routinely. This also means that the sorts of questions asked of MS have changed. Coping with biomolecule heterogeneity is a key challenge, not generally an issue for small molecule drugs. The data complexity means that mass information alone is insufficient. And at the submission stage, regulators are increasingly concerned about tertiary structure and conformation, something that was not previously an analytical requirement (2). Adding polyethylene glycol (PEG) to already heterogeneous molecules to prolong their half-lives in the body raises..
TOF-MS: A Viable Solution for Crude Oil Extract Analysis
May 1st 2010Crude oil is a generic term for the unrefined flammable liquid that is mined from the ground. It is an extremely varied and very complex medium that can contain many thousands of organic compounds, whose contents and concentrations vary enormously from one sample to another. This article discusses how recent advances in time-of-flight-mass spectrometry coupled with comprehensive two-dimensional gas chromatography is helping the petrochemical industry to characterize crude oils more fully and so provide solutions to common problems experienced during drilling, extraction, and refining.
Enhancing Mass Spectral Formula Determination by Heuristic Rules
May 1st 2010A new approach to enhancing the performance of formula identification of true unknowns beyond high mass and spectral accuracy was evaluated. Three heuristic rules on upper limits and ratios of elements were tested for their effectiveness in filtering out false positive formulas with both high- and low-resolution mass spectrometry data. The rule on elements' upper limits was found to be the most effective one in eliminating incorrect formulas.
Translating HPLC Performance Gains of Core-Shell Media to LC–MS Applications
May 1st 2010Adapting the use of "ultrahigh" performance chromatography for liquid chromatography–mass spectrometry (LC–MS) applications requires specific considerations in integrating the instrument platforms. Mobile phase options are limited to volatile buffers, and slow MS sampling rates can limit throughput advantages that such next-generation media offer. High-throughput LC–MS methods of different relevant pharmaceutical and environmental mixtures were developed using ultrahigh performance core-shell media. Such methods were developed using standard HPLC systems and back pressures, showing the ease and utility of using core-shell media for increasing throughput of LC–MS methods.