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High-Throughput Analysis of Metabolic Stability Incubations

This application note describes the use of Acclaim® Rapid Separation Liquid Chromatography (RSLC) columns (Dionex Corporation) and the AB SCIEX 4000 QTRAP® System (AB Sciex) to measure Bisphenol A in water.

Biotage and MIP Technologies have announced that the owners of the two companies have reached an agreement that will see Biotage will acquire all outstanding shares in MIP Technologies and assume ownership of the company.

With the introduction of a new dedicated Polyphenol Analyzer by Antec, sensitive analysis of polyphenols in food and beverages at low costs has become possible in routine.

News from the chromatography world in May 2010.

Capillary flow technology improves the time-tested practice of backflushing in petrochemical analysis.

The 28th International Symposium on Chromatography (the ISC Symposium) is one of the top international congresses in separation science.

Upcoming educational courses for chromatographers.

Upcoming events in the chromatography community as of May 2010.

A method has been developed for detecting arsenic in animal feed, according to a study published in the Journal of Agricultural and Food Chemistry.

Novasep, producer of active molecules for the life science industry, has announced the appointments of two managers in what it describes as a drive to grow the group?s US presence and develop its Novasep Synthesis division.

What is the best way to clean protein residues from a bonded-silica reversed-phase column?

PerkinElmer has announced that its technology can be used to ensure the safety of traditional Chinese herbal medicines.

A selection of the latest developments in chromatography software.

Covidien has announced that its Mallinckrodt Baker business unit has entered into a multi-year agreement with global laboratory supply company, VWR International to distribute Mallinckrodt Baker?s J.T.Baker brand products in Eastern and Central Europe.

Antec will display its award winning ROXY™ EC systems used up-front MS for on-line Electrochemistry/MS during the 58th ASMS Conference on Mass Spectrometry and Allied Topics held in Salt Lake City, Utah, USA, May 23–27, 2010...

Only Agilent LC/MS platforms let you take full advantage of UHPLC and HPLC-Chip separations for your most demanding qualitative and quantitative analyses.

Kalexsyn chose to implement an ELN - instead of paper - from Day One.

DataApex is an independent software company with expertise in developing and manufacturing chromatography data stations. DataApex?s solution combines hardware and software developed in DataApex laboratories with a commitment to providing quality technical support.

analytica China, which is being held at the Shanghai New International Exhibition Centre from 15?17 September 2010, has announced some of the highlights in its programme of events.

It has been revealed that the collaboration between Thermo Fisher Scientific?s Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center and three organizations will be extended.

Thermo Fisher Scientific and Professor Bruno Domon, director of the new Luxembourg Clinical Proteomics unit (LCP), have announced a collaboration to develop workflows to overcome current bottlenecks in biomarker discovery and assay development for clinical proteomics research.

Can a UHPLC approach be easily transferred to speed up GPC/SEC measurements? Unfortunately, the answer is: No! But there are other solutions to make GPC/SEC faster

Hyphenation between thermal desorption (TD), gas chromatography and mass spectrometry detection has been employed by a team from Romania to find if it is possible to discriminate between Romanian and Baltic ambers, two closely related amber species.

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The latest ion chromatography system from Dionex has been awarded the Bronze star in the GIT Innovations Award 2010. Presented by German magazine GIT Labor-Fachzeitchrift, the award was in the category of ?Analytical Instruments and Software?.

Those fond of puns point out that mass spectrometry (MS) has become ever more focused in the last two decades, while at the same time offering ever more information. The dynamic market for biotherapeutics has driven a number of developments, particularly following the paradigm of well-characterized biopharmaceutical products (WCBP) (1,2). Partly as a result of automation and interfacing, those trained in biological or biochemical disciplines now use mass spectrometers routinely. This also means that the sorts of questions asked of MS have changed. Coping with biomolecule heterogeneity is a key challenge, not generally an issue for small molecule drugs. The data complexity means that mass information alone is insufficient. And at the submission stage, regulators are increasingly concerned about tertiary structure and conformation, something that was not previously an analytical requirement (2). Adding polyethylene glycol (PEG) to already heterogeneous molecules to prolong their half-lives in the body raises..

Crude oil is a generic term for the unrefined flammable liquid that is mined from the ground. It is an extremely varied and very complex medium that can contain many thousands of organic compounds, whose contents and concentrations vary enormously from one sample to another. This article discusses how recent advances in time-of-flight-mass spectrometry coupled with comprehensive two-dimensional gas chromatography is helping the petrochemical industry to characterize crude oils more fully and so provide solutions to common problems experienced during drilling, extraction, and refining.

A new approach to enhancing the performance of formula identification of true unknowns beyond high mass and spectral accuracy was evaluated. Three heuristic rules on upper limits and ratios of elements were tested for their effectiveness in filtering out false positive formulas with both high- and low-resolution mass spectrometry data. The rule on elements' upper limits was found to be the most effective one in eliminating incorrect formulas.