Accelerating metabolic research
Agilent Technologies and Stemina Biomarker Discovery have announced that Agilent will be providing a liquid chromatography system and quadrupole time-of-flight mass spectrometer to accelerate Stemina's metobolomic research.
Agilent Technologies and Stemina Biomarker Discovery have announced that Agilent will be providing a liquid chromatography system and quadrupole time-of-flight mass spectrometer to accelerate Stemina's metobolomic research. The research team uses metabolomic analysis of stem cells for the discovery of biomarkers for use in drug screening and drug development. Software will also be supplied to help researchers interpret the complex data generated by metabolomics experiments.
"We are pleased to broaden our relationship with Agilent to advance our scientific platform and our discovery of important small molecules involved in developmental toxicity and autism," said Beth Donley, Stemina CEO.
"Metabolomics is a major growth area for us, and the innovative work being done at Stemina is the kind we like to support," said Gustavo Salem, Agilent vice president and general manager, Biological Systems Division. "We've aggressively built an LC–MS portfolio for the life sciences in recent years, and the software provides the crucial ability to visualize biological pathways from the massive and complex data sets generated by metabolomics studies."
For more information on the research company visit www.stemina.com
More information on the products is available at www.agilent.com
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
