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Crude oil is a generic term for the unrefined flammable liquid that is mined from the ground. It is an extremely varied and very complex medium that can contain many thousands of organic compounds, whose contents and concentrations vary enormously from one sample to another. This article discusses how recent advances in time-of-flight-mass spectrometry coupled with comprehensive two-dimensional gas chromatography is helping the petrochemical industry to characterize crude oils more fully and so provide solutions to common problems experienced during drilling, extraction, and refining.

A new approach to enhancing the performance of formula identification of true unknowns beyond high mass and spectral accuracy was evaluated. Three heuristic rules on upper limits and ratios of elements were tested for their effectiveness in filtering out false positive formulas with both high- and low-resolution mass spectrometry data. The rule on elements' upper limits was found to be the most effective one in eliminating incorrect formulas.

Associate Editor Meg Evans previews the upcoming ASMS conference, taking place May 23–27, 2010 in Salt Lake City, Utah.

Adapting the use of "ultrahigh" performance chromatography for liquid chromatography–mass spectrometry (LC–MS) applications requires specific considerations in integrating the instrument platforms. Mobile phase options are limited to volatile buffers, and slow MS sampling rates can limit throughput advantages that such next-generation media offer. High-throughput LC–MS methods of different relevant pharmaceutical and environmental mixtures were developed using ultrahigh performance core-shell media. Such methods were developed using standard HPLC systems and back pressures, showing the ease and utility of using core-shell media for increasing throughput of LC–MS methods.

For anyone who makes his or her living in the field of analytical chemistry, and more specifically, in the fields of chromatography or spectroscopy, the debate concerning the state of the conference industry is well known to say the least.

A number of clinical situations now call for high-sensitivity measurement of estrogens, including monitoring during female hormone replacement therapy, antiestrogen treatment, and estrogen deficiency in men. Traditional immunoassay methods and liquid chromatography–tandem mass spectrometry (LC–MS-MS) do not provide the sensitivity and selectivity required for these applications. In contrast, a gas chromatography–negative chemical ionization–tandem mass spectrometry (GC–NCI-MS-MS) platform can provide detection limits below 1 pg/mL when used in conjunction with the appropriate derivatization protocol, with very short cycle times.

The authors review the requirements for columns specifically designed and manufactured for SFC.

Many readers who also subscribe to LCGC's sister publication, Spectroscopy, may have read industry expert Bob McDowall's November 2009 column on the new posture of the U.S. FDA ("The Tiger Has Sharp New Teeth," Spectroscopy 24[11], 23–29 [2009]). As he saw it, "The new FDA Commissioner wants a strong FDA and is backing her words with action."

Look at the big picture. It may not be appropriate to obsess on the details

The International Symposium on Chromatography (the ISC Symposium) is one of the top international congresses in separation science. With the first symposium held in London in 1956, this conference is the oldest series of scientific meetings devoted to the field of chromatographic science.

Monolith pioneer, Frantisek Svec, brings readers up to date on the latest developments in monoliths for use in chromatography

Click the title above to open the LCGC North America May 2010 regular issue, Vol 28 No 5, in an interactive PDF format.

The workhorse technique of GC–MS continues to lead the way in application areas from environmental analysis to food and beverage research.

Using as examples an ultra-high temperature (UHT) processed milk and a baby milk powder sample, this work presents a fully automated sample preparation setup coupled to the new ion chromatograph 881 Compact IC pro

Designed to Replace HPLC Systems and Accelerate UPLC Adoption among HPLC Users

Bruker Daltonics and Kiestra Lab Automation have announced an alliance in the co-marketing and cross selling of their products, as well as a joint research and development programme for interfacing their technologies.

Agilent Technologies has released a statement reporting that its portfolio of DNA microarrays is now manufactured under ISO 13485 certification, a recognized standard for quality management systems (QMS).

LECO Apps Notes - Pegasus® 4D GCxGC-TOFMS analysis of 3-MCPD esters in edible oils

Thermo Fisher Scientific has acquired Proxeon A/S, a supplier of products for proteomics analysis headquartered in Odense, Denmark.

UHPLC systems represent the latest development in liquid chromatography instrumentation. Beside enhancements necessary to operate with sub 2 µm particle columns, they differ from each other through their versatility in handling various applications on the same instrument without any changes.

Now you can get comprehensive repair, maintenance and compliance support for all major LC, GC and MS models in your lab regardless of manufacturer.

Pittcon has always served as a showcase for innovations in laboratory science, as well as provided the perfect venue for leading scientists to share their latest research and findings... and this year is no exception.

New from Agilent: Poroshell 120 — A total lab productivity enhancer!

Thermo Fisher Scientific and Symyx Technologies have collaborated to offer Thermo Scientific?s chromatography data system integration solution on Symyx Technologies? electronic laboratory notebook.

A person-portable gas chromatography–mass spectrometry (GC–MS) system employing a toroidal ion trap mass spectrometry (TMS) detector was used to analyze chemical threat related compounds.

On Wednesday 21 and Thursday 22 April, Metrohm UK will be hosting open days at the company?s Runcorn facility in Cheshire, UK.

Participants in this Technology Forum are Richard Jack of Dionex, Jack Cochran of Restek, and Lucas Smith of LECO.

Agilent Technologies has announced a strategic partnership with Pacific Laboratory Products in Australia.

Biochrom launches the Biochrom 30+ Series of amino acid analyzers - the gold standard in dedicated amino acid analysis...

The Green Chemistry Group proudly hosts SFC 2010 from 15–16 September in Stockholm, Sweden. This year's conference will be chaired by Drs Shalini Andersson of AstraZeneca and Eric Francotte of Novartis and will feature some of the top analytical chemists and purification specialists from around the world...