All News

DataApex is an independent software company with expertise in developing and manufacturing chromatography data stations. DataApex?s solution combines hardware and software developed in DataApex laboratories with a commitment to providing quality technical support.

analytica China, which is being held at the Shanghai New International Exhibition Centre from 15?17 September 2010, has announced some of the highlights in its programme of events.

It has been revealed that the collaboration between Thermo Fisher Scientific?s Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center and three organizations will be extended.

Thermo Fisher Scientific and Professor Bruno Domon, director of the new Luxembourg Clinical Proteomics unit (LCP), have announced a collaboration to develop workflows to overcome current bottlenecks in biomarker discovery and assay development for clinical proteomics research.

Can a UHPLC approach be easily transferred to speed up GPC/SEC measurements? Unfortunately, the answer is: No! But there are other solutions to make GPC/SEC faster

Hyphenation between thermal desorption (TD), gas chromatography and mass spectrometry detection has been employed by a team from Romania to find if it is possible to discriminate between Romanian and Baltic ambers, two closely related amber species.

rgsrgssdfgdfg

The latest ion chromatography system from Dionex has been awarded the Bronze star in the GIT Innovations Award 2010. Presented by German magazine GIT Labor-Fachzeitchrift, the award was in the category of ?Analytical Instruments and Software?.

Those fond of puns point out that mass spectrometry (MS) has become ever more focused in the last two decades, while at the same time offering ever more information. The dynamic market for biotherapeutics has driven a number of developments, particularly following the paradigm of well-characterized biopharmaceutical products (WCBP) (1,2). Partly as a result of automation and interfacing, those trained in biological or biochemical disciplines now use mass spectrometers routinely. This also means that the sorts of questions asked of MS have changed. Coping with biomolecule heterogeneity is a key challenge, not generally an issue for small molecule drugs. The data complexity means that mass information alone is insufficient. And at the submission stage, regulators are increasingly concerned about tertiary structure and conformation, something that was not previously an analytical requirement (2). Adding polyethylene glycol (PEG) to already heterogeneous molecules to prolong their half-lives in the body raises..

Crude oil is a generic term for the unrefined flammable liquid that is mined from the ground. It is an extremely varied and very complex medium that can contain many thousands of organic compounds, whose contents and concentrations vary enormously from one sample to another. This article discusses how recent advances in time-of-flight-mass spectrometry coupled with comprehensive two-dimensional gas chromatography is helping the petrochemical industry to characterize crude oils more fully and so provide solutions to common problems experienced during drilling, extraction, and refining.

A new approach to enhancing the performance of formula identification of true unknowns beyond high mass and spectral accuracy was evaluated. Three heuristic rules on upper limits and ratios of elements were tested for their effectiveness in filtering out false positive formulas with both high- and low-resolution mass spectrometry data. The rule on elements' upper limits was found to be the most effective one in eliminating incorrect formulas.

Associate Editor Meg Evans previews the upcoming ASMS conference, taking place May 23–27, 2010 in Salt Lake City, Utah.

Adapting the use of "ultrahigh" performance chromatography for liquid chromatography–mass spectrometry (LC–MS) applications requires specific considerations in integrating the instrument platforms. Mobile phase options are limited to volatile buffers, and slow MS sampling rates can limit throughput advantages that such next-generation media offer. High-throughput LC–MS methods of different relevant pharmaceutical and environmental mixtures were developed using ultrahigh performance core-shell media. Such methods were developed using standard HPLC systems and back pressures, showing the ease and utility of using core-shell media for increasing throughput of LC–MS methods.

For anyone who makes his or her living in the field of analytical chemistry, and more specifically, in the fields of chromatography or spectroscopy, the debate concerning the state of the conference industry is well known to say the least.

A number of clinical situations now call for high-sensitivity measurement of estrogens, including monitoring during female hormone replacement therapy, antiestrogen treatment, and estrogen deficiency in men. Traditional immunoassay methods and liquid chromatography–tandem mass spectrometry (LC–MS-MS) do not provide the sensitivity and selectivity required for these applications. In contrast, a gas chromatography–negative chemical ionization–tandem mass spectrometry (GC–NCI-MS-MS) platform can provide detection limits below 1 pg/mL when used in conjunction with the appropriate derivatization protocol, with very short cycle times.

The authors review the requirements for columns specifically designed and manufactured for SFC.

Many readers who also subscribe to LCGC's sister publication, Spectroscopy, may have read industry expert Bob McDowall's November 2009 column on the new posture of the U.S. FDA ("The Tiger Has Sharp New Teeth," Spectroscopy 24[11], 23–29 [2009]). As he saw it, "The new FDA Commissioner wants a strong FDA and is backing her words with action."

Look at the big picture. It may not be appropriate to obsess on the details

The International Symposium on Chromatography (the ISC Symposium) is one of the top international congresses in separation science. With the first symposium held in London in 1956, this conference is the oldest series of scientific meetings devoted to the field of chromatographic science.

Monolith pioneer, Frantisek Svec, brings readers up to date on the latest developments in monoliths for use in chromatography

Click the title above to open the LCGC North America May 2010 regular issue, Vol 28 No 5, in an interactive PDF format.

The workhorse technique of GC–MS continues to lead the way in application areas from environmental analysis to food and beverage research.

Using as examples an ultra-high temperature (UHT) processed milk and a baby milk powder sample, this work presents a fully automated sample preparation setup coupled to the new ion chromatograph 881 Compact IC pro

Designed to Replace HPLC Systems and Accelerate UPLC Adoption among HPLC Users

Bruker Daltonics and Kiestra Lab Automation have announced an alliance in the co-marketing and cross selling of their products, as well as a joint research and development programme for interfacing their technologies.

Agilent Technologies has released a statement reporting that its portfolio of DNA microarrays is now manufactured under ISO 13485 certification, a recognized standard for quality management systems (QMS).

LECO Apps Notes - Pegasus® 4D GCxGC-TOFMS analysis of 3-MCPD esters in edible oils

Thermo Fisher Scientific has acquired Proxeon A/S, a supplier of products for proteomics analysis headquartered in Odense, Denmark.

UHPLC systems represent the latest development in liquid chromatography instrumentation. Beside enhancements necessary to operate with sub 2 µm particle columns, they differ from each other through their versatility in handling various applications on the same instrument without any changes.

Now you can get comprehensive repair, maintenance and compliance support for all major LC, GC and MS models in your lab regardless of manufacturer.