Distribution agreement for laboratory chemicals
May 10th 2010Covidien has announced that its Mallinckrodt Baker business unit has entered into a multi-year agreement with global laboratory supply company, VWR International to distribute Mallinckrodt Baker?s J.T.Baker brand products in Eastern and Central Europe.
Biomarker research collaboration
May 5th 2010Thermo Fisher Scientific and Professor Bruno Domon, director of the new Luxembourg Clinical Proteomics unit (LCP), have announced a collaboration to develop workflows to overcome current bottlenecks in biomarker discovery and assay development for clinical proteomics research.
Branching Out: Mass Spectrometry and the Shape of Biotherapeutics
May 1st 2010Those fond of puns point out that mass spectrometry (MS) has become ever more focused in the last two decades, while at the same time offering ever more information. The dynamic market for biotherapeutics has driven a number of developments, particularly following the paradigm of well-characterized biopharmaceutical products (WCBP) (1,2). Partly as a result of automation and interfacing, those trained in biological or biochemical disciplines now use mass spectrometers routinely. This also means that the sorts of questions asked of MS have changed. Coping with biomolecule heterogeneity is a key challenge, not generally an issue for small molecule drugs. The data complexity means that mass information alone is insufficient. And at the submission stage, regulators are increasingly concerned about tertiary structure and conformation, something that was not previously an analytical requirement (2). Adding polyethylene glycol (PEG) to already heterogeneous molecules to prolong their half-lives in the body raises..