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Fast Semivolatiles Analysis Harmonized for EPA Methods 625.1 and 8270E Using Supported Liquid Extraction and GC–MS/MSA supported liquid extraction (SLE) and fast gas chromatography–tandem mass spectroscopy (GC–MS/MS) method, used in multiple reaction monitoring (MRM) mode, was developed for the analysis of semivolatile organic compounds (SVOCs) in environmental samples, according to the updated EPA Methods 625.1 and 8270E. This method requires minimal sample handling and yields significant throughput and productivity gains in the laboratory.
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Evaporation-Free Extraction and Application in High-Throughput Bioanalysis by LC–MS-MSEvaporation-free extraction (no drying down) is highly desirable because of its reduced cost and pollution, higher speed, and less possibility for contamination and conversion. Presented in this article are four types of evaporation-free extraction that are widely applicable. The first one is for the determination of didanosine over the range of 25.02–2502.00 ng/mL by injecting solid-phase extraction (SPE) eluate directly. The second is for the determination of betamethasone phosphate over the range of 2.51–250.60 ng/mL by injecting SPE eluate after pH adjustment. The third is for the determination of sumatriptan over the range of 0.99–99.40 ng/mL based upon SPE with high organic washing and low organic elution. The fourth is based upon automated dilution after protein precipitation for the determination of raloxifene-4'-glucuronide and raloxifene-6-glucuronide over the ranges of 2.02–202.40 ng/mL and 0.40–39.95 ng/mL, respectively.
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Fast Determination of Anthocyanins to Authenticate Pomegranate JuiceAnthocyanins are a sub-class of naturally electron deficient and powerful antioxidants called flavonoids that are responsible for the red, orange, and blue coloration in fruits and flowers.
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Pickering Laboratories - Analysis of Mycotoxins in Hemp and Hemp- Containing Edible ProductsPickering Laboratories developed an easy and sensitive method to analyze aflatoxins B1, B2, G1, G2, and ochratoxin A in hemp and hemp-containing edible products. Mycotoxins are isolated using immunoaffinity clean-up columns and analyzed with fluorescence detection. To increase sensitivity of aflatoxins B1 and G1, an in-line photochemical reactor (UVETM) is installed before the detector. This method utilizes standard HPLC equipment and allows laboratories to easily determine these mycotoxins at low ppb levels.
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Characterization and Prediction of Emulsification Performance of Acacia GumsThe authors use GPC coupled online to multiangle laser light scattering, refractive index, and ultra violet (UV) detectors for the characterization of Acacia gum (gum arabic).
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The Benefits of ICP-MS for the Determination of Toxic and Nutritional Elements in the Cannabis Family of Flowering PlantsThis study will focus on an ICP-MS sample preparation procedure and analytical methodology optimized for both toxic and nutritional elements in dried hops, a surrogate for the cannabis family of flowering plants. It will show that the wide dynamic range of the technique allows it to be used for the simultaneous determination of parts per billion (ppb) levels of heavy metals including Pb, As, Cd and Hg, together with high parts per million (ppm) levels of nutritional elements, such as P, Ca, K and Mg.
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Automated Solid Phase Extraction for Efficient Extraction of Fluoroquinolone Antibiotics from FishThe global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population.
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The Use of Temperature to Eliminate Organic Solvent in Analytical HPLC MethodsIncreased temperature has been used to assist the elimination of organic modifier required in the mobile phase, to achieve analyte separation in pure aqueous mobile phases.
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Quantitative Analysis of Pseudoephedrine Tablets by UHPLC–MSAn effective UHPLC–MS method for high throughput separation, identification and quantification of pseudoephedrine was developed on a Hypersil GOLD PFP 1.9 µm, 2.1 Ã- 100 mm column.
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Rapid, Specific Analysis of Melamine and Cyanuric Acid in Infant FormulaThis method is rapid and sensitive for the analysis of melamine and cyanuric acid simultaneously in infant formula. Using two Oasis solid-phase extraction protocols and the ACQUITY UPLC, the results are consistent with the published US FDA interim method, while demonstrating a reduced analysis time.
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HPLC Analysis of Non-volatile Analytes Using Charged Aerosol DetectionA detection method based upon aerosol charging was examined for its applicability and performance with high performance liquid chromatography.
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Fast and Accurate Determination of Algal Toxins in Water Using On-line Preconcentration and UHPLC–HRAM–MSThe development of a column-switching technique based on on-line preconcentration and HRAM–MS to obtain fast and accurate results for the determination of algal toxins in drinking water is discussed.
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Application of a GPC-LC–MS/MS Method for the Determination of 31 Mycotoxins in Edible OIlsGel Permeation Chromatography (GPC) is widely used for sample clean up in mycotoxin analysis. The most commonly described methods use GPC columns packed with SX-3 BioBeads suitable for cleaning Zearalenone, Aflatoxins, and Trichothesenes from edible oils and fatty matrices. Separation of Fumonisins from the oil fraction are inadequate with this column.
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Gradient Performance Tests for Reversed-Phase and Biochemical Applications using High Salt BuffersIn gradient mode, the quality of the analysis will be influenced by the performance of the proportioning and mixing of the eluents at any time during a given chromatogram.
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The Benefits of ICP-MS for the Determination of Toxic and Nutritional Elements in the Cannabis Family of Flowering PlantsThis study will focus on an ICP-MS sample preparation procedure and analytical methodology optimized for both toxic and nutritional elements in dried hops, a surrogate for the cannabis family of flowering plants. It will show that the wide dynamic range of the technique allows it to be used for the simultaneous determination of parts per billion (ppb) levels of heavy metals including Pb, As, Cd and Hg, together with high parts per million (ppm) levels of nutritional elements, such as P, Ca, K and Mg.
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Recent Advances in Ultrahigh-Pressure Liquid ChromatographyUltrahigh-pressure liquid chromatography (UHPLC) is a technique that is experiencing continued growth due to the benefits in separation power and speed of analysis over traditional HPLC. We attempt here to give an overview of some of the advances that have occurred in UHPLC since 2003, from the standpoint of both fundamental research and the introduction of commercially-available technology.
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Mass Analysis from Kilodaltons to Megadaltons Using Macroion Mobility SpectrometryMass spectrometry (MS) has advanced to analyze ever-larger biomolecules with the invention of soft ionization techniques like electrospray ionization (ESI). Although ESI has provided a method of generating ions of high mass, mass spectrometers generally suffer both lower sensitivity and lower resolution as the mass-to-charge ratio of an ion increases. To extend the mass range of ionized macromolecules beyond the limits of MS, macroion mobility spectrometry utilizes ion mobility sizing to characterize charge-reduced ESI-generated macroions from >5 kDa to beyond megadalton masses. One prominent application of macroion mobility spectrometry, highlighted here, is the high sensitivity analysis of intact proteins, antibodies, and conjugates in which molecular masses range from antibody light-chain fragments to high mass immunoglobulin multimers.
Latest:
Application of a GPC-LC–MS/MS Method for the Determination of 31 Mycotoxins in Edible OIlsGel Permeation Chromatography (GPC) is widely used for sample clean up in mycotoxin analysis. The most commonly described methods use GPC columns packed with SX-3 BioBeads suitable for cleaning Zearalenone, Aflatoxins, and Trichothesenes from edible oils and fatty matrices. Separation of Fumonisins from the oil fraction are inadequate with this column.
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Method Translation in Gas ChromatographyThe advantages of using software to optimize GC methods with practical examples for pesticide analysis are described.
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Nanometer Internal Diameter Fused Silica Capillary TubingScientists employ fused silica capillary tubing routinely in a wide range of analytical applications, encompassing GC, CE, capillary LC, and CEC. It has proven as an ideal substrate for interfacing in hyphenated techniques.
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Control of Matrix Effects in Bioanalytical MS–MS Using On-line Multidimensional Solid-Phase ExtractionThe authors discuss a solid-phase extraction (SPE) clean-up procedure for drugs present in biofluids.
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Volatile Organic Compounds in Wastewater: Performance of US EPA Method 624 on Modern GC–MS and Purge and Trap InstrumentationUS EPA wastewater method 624 Purgeables was originally published as 40 CFR Part 136 Appendix A in the mid 1980s.
