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Analysis of Pesticide Residues in Apples using Agilent SampliQ QuEChERS AOAC Kit by LC–MS–MS DetectionBased on the QuEChERS AOAC Official Method 2007.01, 16 pesticides were used for evaluating the performance of the Agilent's AOAC buffered extraction and SampliQ QuEChERS dispersive SPE kits for general fruits and vegetables.
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A Generic Headspace GC Method for Residual Solvents in Pharmaceutical: Benefits, Rationale, and Adaptations for New Chemical EntitiesA generic static headspace gas chromatographic (HSGC) method for determining common residual solvents in pharmaceuticals is described.
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LC/MS Screening for EDTA in Fresh Blood Swabs Using an Expression CMS SystemExplore the potential for screening human blood fortified with ethylenediaminetetraacetic acid (EDTA) via LC/MS using an expression single quadrupole compact mass spectrometer.
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Rapid Quality Control of Flavours and Fragrances using Fast GC–MS and Multi-MS Library Search ProceduresUsing narrow-bore column fast GC combined with rapid scanning qMS to analyse flavours and fragrances is described.
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Reliable and Efficient Sulfur Detection in Proteins Using ICP-MS with Capillary LCWith recent research, the University of Oviedo's analytical spectrometry research group has taken a step closer to the absolute quantification of proteins. Quantification based upon isotope dilution mass spectrometry of sulfur is hampered by gas-based polyatomic interferences. By implementing a quadrupole inductively coupled mass spectrometer with collision/reaction cell technology, the group has been able to overcome the issues and has increased reliability while optimizing the efficiency of its analyses.
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Simplifying Solid-Phase Extraction Method Development: Exploring the Use of SoftwareSPE is a popular sample preparation technique, valued by analysts working with complex matrices.
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A Generic Headspace GC Method for Residual Solvents in Pharmaceutical: Benefits, Rationale, and Adaptations for New Chemical EntitiesA generic static headspace gas chromatographic (HSGC) method for determining common residual solvents in pharmaceuticals is described.
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High-Definition Screening for Boar Taint in Fatback Samples Using GC–MSHigh-definition screening by gas chromatography–mass spectrometry (GC–MS) is shown to be a viable option for the reliable identification of odorous compounds in pork.
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Gas Chromatography: Separation Power, Selectivity, Sensitivity, Speed, and Now....SustainabilityA chronological examination of GC is presented here, with a look at where the technique is heading and how it can be used to advance environmental sustainability.
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Unravelling the Complexity of Fragrances in HPC* Products Using TruTOF GC–TOF-MS with Automated Data DeconvolutionThe composition and analysis of fragrance components in home and personal care (HPC) products is very complex and unquestionably time consuming.
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Getting the Most Out of Calibration StandardsIn this month's "LC Troubleshooting," the authors look at another use of calibration standards: to monitor the quality of the data, with a goal toward helping scientists troubleshoot instrument problems.
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Comparison of Ion Trap and Q-TOF Mass Spectrometers for Protein IdentificationThis study uses the challenging analysis of a complex, multi-organ peptide digest of Caenorhabditis elegans (C. elegans) to compare the performance of a novel linear ion trap mass spectrometer and a quadrupole time-of-flight (Q-TOF) mass spectrometer.
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Improving HPLC Separation of PolyphenolsThis article highlights a number of recent developments in HPLC for polyphenol analysis.
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Comparison of Liquid–Liquid Extraction (LLE) and Supported Liquid Extraction (SLE): Equivalent Limits of Quantification with Smaller Sample VolumesIn this application, we demonstrate the use of supported liquid extraction (SLE) for the extraction of beta blockers and NSAIDS from plasma compared with traditional liquid–liquid extraction. SLE was demonstrated to yield consistent LOQs using lower sample volumes.
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Quantitative Proteomic Workflow for Discovery of Early Rejection Kidney Transplant Peptide Biomarkers and Subsequent Development of SRM Assays in UrineThe accurate diagnosis of renal allograft rejection currently depends upon a biopsy. Transplant medicine would benefit greatly from the availability of noninvasive tests for early detection of rejection and immunosuppressive drug therapeutic monitoring. Only a limited number of studies have been published to date on specific proteins associated with allograft rejection. Typically, renal dysfunction due to humoral transplant rejection or other pathologies results in the increase of protein excreted in urine (1–5). In blood, endogenous peptides (not generated by trypsin digestion ex vivo) are likely candidate biomarkers for many diseases and pathologies as they are secreted from tissues and enter the bloodstream (6,7). The analysis of endogenous protein and peptide fragments in urine can provide a noninvasive, early indication of kidney transplant rejection or disease.
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Quantitative Proteomic Workflow for Discovery of Early Rejection Kidney Transplant Peptide Biomarkers and Subsequent Development of SRM Assays in UrineThe accurate diagnosis of renal allograft rejection currently depends upon a biopsy. Transplant medicine would benefit greatly from the availability of noninvasive tests for early detection of rejection and immunosuppressive drug therapeutic monitoring. Only a limited number of studies have been published to date on specific proteins associated with allograft rejection. Typically, renal dysfunction due to humoral transplant rejection or other pathologies results in the increase of protein excreted in urine (1–5). In blood, endogenous peptides (not generated by trypsin digestion ex vivo) are likely candidate biomarkers for many diseases and pathologies as they are secreted from tissues and enter the bloodstream (6,7). The analysis of endogenous protein and peptide fragments in urine can provide a noninvasive, early indication of kidney transplant rejection or disease.
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Review of Volatile Perfluorocarboxylic Acids as Ion Pair Reagents in LC: Part IIIn Part II, we review MS ionization suppression; column, pH, and temperature selection; and system peaks and column equilibration issues associated with the use of five volatile perfluorocarboxylic acid reagents in LC.
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The QuEChERSER Mega-MethodQuEChERS has been updated to suit modern instrumentation. Now also “efficient and robust,” QuEChERSER is a “mega-method” that covers a wider polarity range.
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Current Progress in Chiral Stationary Phase Development and an Update of Chiral ApplicationsThis discusses using generic chiral stationary phase screening to find the optimum column, smaller diameter columns for HPLC and SFC, clones of off-patent phases, and new concepts in CSP development.
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Comparison of Liquid–Liquid Extraction (LLE) and Supported Liquid Extraction (SLE): Equivalent Limits of Quantification with Smaller Sample VolumesIn this application, we demonstrate the use of supported liquid extraction (SLE) for the extraction of beta blockers and NSAIDS from plasma compared with traditional liquid–liquid extraction. SLE was demonstrated to yield consistent LOQs using lower sample volumes.
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Gel Permeation Chromatography (GPC) for Process Control and Quality Control in Polyethylene and Polypropylene Manufacturing PlantsA method specifically developed to measure the molar mass distribution (MMD) of polyolefins in a manufacturing plant laboratory has been developed. It is demonstrated that the total cycle time, including the sample dissolution step, can be reduced to around 30 min, well in line with the process control requirements.
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Analysis of 17-Pesticide Residues in Apple Using Agilent SampliQ QuEChERS EN Kits and Agilent J&W Ultra Inert columns by GC–MSThe QuEChERS method for pesticide analysis was first introduced by USDA scientists in 2003. The EN method 15662:2007 is a European variation to the QuEChERS method. The method uses acetonitrile extraction, followed by the salting out of water from the sample using anhydrous magnesium sulphate (MgSO4, NaCl and buffering citrate salts to induce liquid–liquid partitioning.
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Real-Time Response to Bacteria Infection of Bioethanol Fermentation Using a Short Rezex™ ROA ColumnPolitical priorities as well as economic interests have fueled a dramatic growth in the biofuel industry, due much in part to research funding and tax incentives. Currently the world's ethanol production is estimated to be over 16 billion gallons a year. This number is expected to increase in the next few years, reaching an estimated yearly production of 20 billion gallons by 2012. Today, many ethanol producers add fermentors to expand their production capacity. In order to continue using existing HPLC equipment for the increased monitoring, increased analytical throughput is needed.
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From Academician to Entrepreneur — A Convoluted TrekWalt Jennings briefly sketches a path, occasionally humorous, occasionally somber, from the time of his Ph.D. candidacy in 1953 to the present day.
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Headspace Analysis of Volatile Organic Compounds (VOCs) in Contact Packaging Materials Using the HT3 Automated Headspace AnalyzerThe United States Food and Drug Administration (U.S. FDA) and the European Union (EU) have published regulations and provided guidance on the use of chemicals in food packaging materials. Tekmar provides method parameters for the HT3â„¢ Automated Headspace Analyzer for the determination of VOCs that may be contained in food contact packaging materials under various conditions. Temperature and mixing parameters were investigated to determine which VOCs may be released when subjected to these conditions.
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Recent Advances in Ultrahigh-Pressure Liquid ChromatographyUltrahigh-pressure liquid chromatography (UHPLC) is a technique that is experiencing continued growth due to the benefits in separation power and speed of analysis over traditional HPLC. We attempt here to give an overview of some of the advances that have occurred in UHPLC since 2003, from the standpoint of both fundamental research and the introduction of commercially-available technology.
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Quantitative Analysis of Pseudoephedrine Tablets by UHPLC–MSAn effective UHPLC–MS method for high throughput separation, identification and quantification of pseudoephedrine was developed on a Hypersil GOLD PFP 1.9 µm, 2.1 Ã- 100 mm column.
