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This study illustrates the versatility of a laser-induced acoustic desorption (LIAD) approach for volatilization of analytes in modern mass spectrometry.

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Proteins - especially monoclonal antibodies (MABs) - have become increasingly important in pharmaceutical work. However, there are some important differences between conventional, chemically-synthesized drugs and proteins. Because of the complex and weak structure of proteins, even a slight change in conditions, such as pH value, temperature, or mechanical stress, may lead to aggregation and a loss of activity or stability.

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In food analysis, many different biological matrices are investigated containing numerous compounds that can interfere with liquid chromatographyÐmass spectrometry (LC–MS) analysis. To overcome the challenges that arise with these highly complex matrices, the additional separation of analytes and matrix compounds complementing chromatographic separation is becoming more significant. In this article, the potential of IM-MS to increase selectivity and for additional identity confirmation is investigated. An extensive evaluation of IM-MS instruments was performed on a broad test set of food safety contaminants. The tested IM-MS platforms were DMS, TWIMS, low field DTIMS, and TIMS. CCS data were determined using the different instruments, and the ability to separate isomers and compounds of interest from sample matrix in the IM dimension was explored.

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This article discusses the benef ts of using automated dispersive solid-phase extraction (dSPE) rather than standard SPE in urine analysis.

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Is that peak “pure”? How do I know if there might be something hiding under there?

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SFC–GCxGC is shown to be useful in fossil fuel analysis. Practical examples for the analysis of complex matrices are described.

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Two-dimensional LC, with advanced modulation techniques, can advance the analysis of advanced polymeric materials, assisting in characterizing copolymer composition heterogeneity and identifying ingredients in complex products.

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This article describes and tests a dynamic DHS−TD−GC−MS method for the fingerprinting analysis of mobile volatile organic compounds in soil.

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The authors introduce a new high-throughput approach for analyzing environmental micropollutants.

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The authors introduce a new high-throughput approach for analyzing environmental micropollutants.

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The chemical analysis of organic compounds in environmental samples is often targeted on predetermined analytes. A major shortcoming of this approach is that it invariably excludes a vast number of compounds of unknown relevance. Nontargeted chemical fingerprinting analysis addresses this problem by including all compounds that generate a relevant signal from a specific analytical platform and so more information about the samples can be obtained. A DHS−TD−GC−MS method for the fingerprinting analysis of mobile VOCs in soil is described and tested in this article. The analysis parameters, sorbent tube, purge volume, trapping temperature, drying of sorbent tube, and oven temperature were optimized through qualitative and semiquantitative analysis. The DHS−TD–GC−MS fingerprints of soil samples from three sites with spruce, oak, or beech were investigated by pixel-based analysis, a nontargeted data analysis method.

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This article describes and tests a dynamic DHS−TD−GC−MS method for the fingerprinting analysis of mobile volatile organic compounds in soil.

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This article describes and tests a dynamic DHS−TD−GC−MS method for the fingerprinting analysis of mobile volatile organic compounds in soil.

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Tuesday, November 9, 2021 at 1pm EST | 12pm CST | 10am PST Learn how limit the evaporation of harmful solvents into the lab, and therefore limit the exposure of these toxic solvents to laboratory personnel.

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Proteins - especially monoclonal antibodies (MABs) - have become increasingly important in pharmaceutical work. However, there are some important differences between conventional, chemically-synthesized drugs and proteins. Because of the complex and weak structure of proteins, even a slight change in conditions, such as pH value, temperature, or mechanical stress, may lead to aggregation and a loss of activity or stability.

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An overview on the present state of analytical lipidomics is presented from the perspective of mass spectrometry (MS) and the MS strategies most frequently used in lipidomics are highlighted.

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Poster discussing what the ICH Q14 guidelines entail and how AutoChrom can help implement these principles. The poster includes details about the ICH Q14 guidelines and specific details about how tools and features within AutoChrom can help implement ICH Q14 principles.

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There have been exciting recent advances in ICP-MS instrumentation, such as the development of magnetic sector ICP-MS, multicollector ICP-MS, time-of-flight ICP-MS, and triple-quadrupole ICP-MS, as well as developments in the coupling of laser ablation (LA) and laser-induced breakdown spectroscopy (LIBS) to ICP-MS. This article surveys these developments and looks to the future.

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Matrix-assisted laser desorption–ionization (MALDI) imaging mass spectrometry allows direct, in situ, label-free measurement of proteins, peptides, lipids, small-molecule drugs and their metabolites, and other chemicals in tissues. In a range of applications, the unique information generated by MALDI imaging can make a significant contribution to understanding factors such as molecular and metabolic mechanisms and the transport and localization of compounds or metabolites with human, animal, or plant species.

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Matrix-assisted laser desorption–ionization (MALDI) imaging mass spectrometry allows direct, in situ, label-free measurement of proteins, peptides, lipids, small-molecule drugs and their metabolites, and other chemicals in tissues. In a range of applications, the unique information generated by MALDI imaging can make a significant contribution to understanding factors such as molecular and metabolic mechanisms and the transport and localization of compounds or metabolites with human, animal, or plant species.

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This article describes possible sources of error that may contribute to significant inaccuracy in peptide assay methods: The fi ltration material (cellulose) used in sample clean up and the vial material (glass and plastic) used in LC analysis. This study is based on ?-endorphin but has relevance for most peptide assays.

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In the human food supply, public confidence is affected by contaminants and misreporting of nutritional information. This article highlights three events that required development of new mass spectrometry methods, including the detection of pesticides (such as fipronil and glyphosate), and the detection and quantification of fat-soluble vitamins.

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In the human food supply, public confidence is affected by contaminants and misreporting of nutritional information. This article highlights three events that required development of new mass spectrometry methods, including the detection of pesticides (such as fipronil and glyphosate), and the detection and quantification of fat-soluble vitamins.

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Ion mobility–mass spectrometry (IM-MS) is outlined as a separations method, several examples of the utility of IM-MS for complex biological measurements are illustrated, and the implications of this approach for systems biology research are discussed.

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The past decade has witnessed resurgent interest in coupling GC to atmospheric-pressure chemical ionization (APCI), which is suitable for the high column flows required for using flow modulation. This study assesses the use of GP-APCI with flow modulation for sensitive detection of selected trace organics.

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Metabolomics, a word coined in 1998, is the study of small molecules (that is, organic chemicals with a molecular weight of 50–2000 Daltons) present in a given biological fluid, tissue, organ, organism, and environment at a given time. Using the power and high throughput of analytical platforms, such as mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectroscopy, metabolomics promises to be a cornerstone in innovations and discoveries in the areas of medicine, agriculture, biomedical, space, and environment. Thus, science, technology, engineering, and mathematics (STEM) graduates and doctorates who interface with analytical chemistry need to prepare for the challenges of academia or industry as metabolomics research takes a centre stage in this big data era.

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The past decade has witnessed resurgent interest in coupling GC to atmospheric-pressure chemical ionization (APCI), which is suitable for the high column flows required for using flow modulation. This study assesses the use of GP-APCI with flow modulation for sensitive detection of selected trace organics.