Author
Latest:
PeakMaster — A Freeware Simulator of Capillary Zone ElectrophoresisThe authors describe how this free downloadable software calculates and displays CZE separations after the user has entered sample and operations parameters. The underlying principles and mathematical basis are explained.
Latest:
Accelerated and Automated Extraction of Hexavalent Chromium from Solid Waste Materials Coupled with Ion Chromatography DeterminationIn this article, the authors describe a method based on the accelerated and automated extraction of hexavalent chromium from solid samples followed by ion chromatography analysis using spectrophotometric detection. The experiments were performed on different samples of sludge and soil.
Latest:
Determining the Hydrocarbon Oil Index in Water using Ultra Fast Gas ChromatographyThis article discusses utra fast gas chromatography as a suitable technique for determining the hydrocarbon oil index in water. The advantages of this technique over conventional GC technology are presented.
Latest:
PeakMaster — A Freeware Simulator of Capillary Zone ElectrophoresisThe authors describe how this free downloadable software calculates and displays CZE separations after the user has entered sample and operations parameters. The underlying principles and mathematical basis are explained.
Latest:
Separating Proteins by pI-Values — Can 2D LC Replace 2D GE?The authors address the specific separation problems of proteins and assess whether 2D liquid chromatography could possibly be considered as an alternative to traditional 2D gel electrophoresis in the future.
Latest:
Separating Proteins by pI-Values — Can 2D LC Replace 2D GE?The authors address the specific separation problems of proteins and assess whether 2D liquid chromatography could possibly be considered as an alternative to traditional 2D gel electrophoresis in the future.
Latest:
Determining the Hydrocarbon Oil Index in Water using Ultra Fast Gas ChromatographyThis article discusses utra fast gas chromatography as a suitable technique for determining the hydrocarbon oil index in water. The advantages of this technique over conventional GC technology are presented.
Latest:
Preparative Chiral SFC as a Green Technology for Rapid Access to Enantiopurity in Pharmaceutical Process ResearchThis month’s column provides an overview of green chemistry issues relating to preparative chiral SFC chromatography in support of preclinical development in the pharmaceutical industry.
Latest:
Preparative Chiral SFC as a Green Technology for Rapid Access to Enantiopurity in Pharmaceutical Process ResearchThis month’s column provides an overview of green chemistry issues relating to preparative chiral SFC chromatography in support of preclinical development in the pharmaceutical industry.
Latest:
Preparative Chiral SFC as a Green Technology for Rapid Access to Enantiopurity in Pharmaceutical Process ResearchThis month’s column provides an overview of green chemistry issues relating to preparative chiral SFC chromatography in support of preclinical development in the pharmaceutical industry.
Latest:
PeakMaster — A Freeware Simulator of Capillary Zone ElectrophoresisThe authors describe how this free downloadable software calculates and displays CZE separations after the user has entered sample and operations parameters. The underlying principles and mathematical basis are explained.
Latest:
IC–MS Determination of Ionic Compounds in ToothpasteA fast and easy-to-use method for the identifcation and determination of active anionic ingredients in toothpaste is presented using ion chromatography in combination with electrospray mass spectrometry. In this application, positive identification of glycerol, sorbitol, chloride, fluoride, sulphate, monofluorophosphate and polyphospates, in addition to citrate and saccharin, is achieved in one chromatographic run with a total analysis time of 22 min.
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Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery ApplicationsThis article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.
Latest:
Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery ApplicationsThis article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.
Latest:
Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery ApplicationsThis article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.
Latest:
Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery ApplicationsThis article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.
Latest:
Molecular Interaction Sensors: A New Type of Detector for Separation MethodsPotentiometry is a new detection method for liquid chromatography (LC) and capillary electrophoresis (CE). The principle behind this method is familiar to chromatographers because the signals depend on the partitioning tendency of analytes over the sensor coating and the eluent. This partitioning provokes a change in the surface potential and the detection of these changes can be classified as "potentiometric". A conversion algorithm is needed to convert the generated signals to concentration-related tracings (chromatograms).
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Shear-Driven Flow LC: Dispensing with Pumps and Voltage Supplied for Increased Speed and ResolutionThe authors discuss the application of shear-driven chromatography, a technique that depends on viscous drag to propel mobile phase in high-resolution/high-speed liquid chromatography. This method, it is claimed, overcomes the pressure- and voltage-drop limitations of both HPLC and CEC. Early development of the technique is reviewed and updated with the current status of the group's work. Also covered are the challenges faced and opportunities available to interface such systems to MS and UV/vis absorption detectors.
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Using Second-Order Data in Chromatographic AnalysisThe authors discuss zero-, first- and second-order data and describe the advantages of using second-order chromatographic data compared with the more traditional univariate or multivariate calibration. They demonstrate how its use can uncover much more information from chromatograms and spectra.
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Molecularly Imprinted Polymers: Developments and Applications of New Selective Solid-Phase Extraction MaterialsMIPs are synthetic polymeric materials possessing specific cavities designed for a target molecule. The various parameters affecting extraction selectivity are discussed in the article and the potential of MIPs as selective sorbents reviewed.
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A Combination of Liquid Chromatography and Mass Spectrometry for Peptidomic ResearchThe guest authors describe the use of LC–MS for the analysis of peptides. They deal with peptide extraction, peptidomic analysis in organisms with and without genomic databases, identification of peptides with conserved N- and C- terminal sequences, and in situ MALDI-TOF peptide profiling.
Latest:
A Combination of Liquid Chromatography and Mass Spectrometry for Peptidomic ResearchThe guest authors describe the use of LC–MS for the analysis of peptides. They deal with peptide extraction, peptidomic analysis in organisms with and without genomic databases, identification of peptides with conserved N- and C- terminal sequences, and in situ MALDI-TOF peptide profiling.
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Multidimensional and Hyphenated Techniques in Aerosol AnalysisThe authors provide suggestions for the sample pretreatment and analysis of aerosol particles including the use of on-line SFE–LC–GC–MS, GCXGC and LC–MS. Although each technique has its merits, the novel multidimensional systems and those integrating sample pretreatment with the final analysis proved to be valuable tools in aerosol analysis.
Latest:
Multidimensional and Hyphenated Techniques in Aerosol AnalysisThe authors provide suggestions for the sample pretreatment and analysis of aerosol particles including the use of on-line SFE–LC–GC–MS, GCXGC and LC–MS. Although each technique has its merits, the novel multidimensional systems and those integrating sample pretreatment with the final analysis proved to be valuable tools in aerosol analysis.
