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Copenhagen Symposium on Separation Sciences (CSSS) Event PreviewThe 2nd Copenhagen Symposium on Separation Sciences (CSSS 2018) will be held on 26–27 June 2018 at the DGI-byen in Copenhagen, Denmark. The preliminary programme of the 2nd CSSS is summarized below and gives an idea of what can be expected.
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Copenhagen Symposium on Separation Sciences (CSSS) Event PreviewThe 2nd Copenhagen Symposium on Separation Sciences (CSSS 2018) will be held on 26–27 June 2018 at the DGI-byen in Copenhagen, Denmark. The preliminary programme of the 2nd CSSS is summarized below and gives an idea of what can be expected.
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Copenhagen Symposium on Separation Sciences (CSSS) Event PreviewThe 2nd Copenhagen Symposium on Separation Sciences (CSSS 2018) will be held on 26–27 June 2018 at the DGI-byen in Copenhagen, Denmark. The preliminary programme of the 2nd CSSS is summarized below and gives an idea of what can be expected.
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Quantitative Multi-Target Screening Using Library-Based IdentificationThis article presents a novel approach for toxicology and pharmacology laboratories that combines multi-compound screening followed by multi-compound determination in a single method. The multi-compound assay developed allows 90 molecules including benzodiazepines, cocaine and related stimulants, amphetamines, and opioids to be measured. The multi-targeted screening (MTS) method was developed using a spectra library containing over 1200 compounds. The approach was evaluated in a routine clinical toxicology laboratory to detect and quantify compounds in unknown samples.
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Copenhagen Symposium on Separation Sciences (CSSS) Event PreviewThe 2nd Copenhagen Symposium on Separation Sciences (CSSS 2018) will be held on 26–27 June 2018 at the DGI-byen in Copenhagen, Denmark. The preliminary programme of the 2nd CSSS is summarized below and gives an idea of what can be expected.
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Anomalous Retention Prediction Using Modelling Software in Gradient Reversed-Phase Liquid Chromatography: Why it Can Occur and How to Prevent ItThe success of screening column and mobile phase combinations that generate dissimilar selectivity is highlighted in a typical method development strategy.
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A Practical Approach to Modelling of Reversed-Phase Liquid Chromatographic Separations: Advantages, Principles, and Possible PitfallsChromatographic principles and best practices for obtaining highly precise retention time, peak width, and resolution predictions for the optimization of reversed-phase liquid chromatography (LC) separations using retention modelling software will be discussed. The importance of fully characterizing the LC instrumentation, how to generate accurate input data, the selection of appropriate models, and peak tracking will be addressed along with a suggested workflow. Adhesion to a few basic rules and simple precautions and the use of modern retention modelling software programmes can assist the rapid development of highly accurate retention models to enable the development of robust and optimized reversed-phase LC separations using either ultrahigh-pressure liquid chromatography (UHPLC) or high performance liquid chromatography (HPLC) conditions. Examples of retention modelling for small and large molecules will be highlighted.
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AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma (October 2024)Deriving antibodies from plasma involves a multi-step process, from plasma collection to antibody purification and quality control, ensuring the final product is safe and effective for therapeutic, diagnostic, or research use. Krish Gosh, PhD, MBA, President of TCG Digital, joined LCGC International to discuss how AI/GenAI applications can optimize several steps to enhance yield, profitability, and process monitoring.
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LC/LC–MSA snapshot of key trends and developments in the chromatography sector according to selected panelists from companies exhibiting at Analytica 2018.
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LC/LC–MSA snapshot of key trends and developments in the chromatography sector according to selected panelists from companies exhibiting at Analytica 2018.
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GC/GC–MSA snapshot of key trends and developments in the GC/GC–MS sector according to selected panelists from companies exhibiting at Analytica 2018.
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Data HandlingA snapshot of key trends and developments in the data handling sector according to selected panelists from companies exhibiting at Analytica 2018.
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Can We Continue to Draw the Line?Chromatographic peak integration continues to be a major regulatory issue and was first discussed in this column in 2015. Is the approach to manual intervention and manual integration outlined still acceptable in the light of regulatory citations and guidance documents published since then?
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Developments in Green ChromatographyWhy should you be concerned about mobile-phase degassing - it's all done automatically, isn't it?
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Determination of Seven Sodium Alkyl Sulphates in Environmental Water by Ion-pair Chromatography with Suppressed Conductivity DetectionA simple and fast ion-pair chromatography method to detect sodium alkyl sulphates in environmental samples using conductivity detection is described.
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Automating Analysis of Pain Management Drugs in UrineThis article discusses the benef ts of using automated dispersive solid-phase extraction (dSPE) rather than standard SPE in urine analysis.
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Host Cell Protein Monitoring During Downstream Processing Using Micro-Pillar Array Columns Combined with Mass SpectrometryThis article investigates host cell protein analysis using micro-pillar array columns combined with mass spectrometry.
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Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in UrineA novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.
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Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in UrineA novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.
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Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in UrineA novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Latest:
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive AnalysesNovel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
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Haloacetic Acid Analysis Using Two-Dimensional Matrix-Elimination Ion ChromatographyThe disinfectants commonly used to treat public drinking water can react with naturally occurring organic and inorganic matter in the source water to form disinfection byproducts such as haloacetic acids. Here, we describe the use of two-dimensional matrix-elimination ion chromatography (MEIC) for haloacetic acid analysis. This method minimizes the impact of matrix ions.
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Scaling LC Methods Using Porous Particle Stationary PhasesThe use of ultrahigh-pressure liquid chromatography (UHPLC) is now commonplace among pharmaceutical laboratories. However, until depreciation cycles replace traditional high performance liquid chromatography (HPLC) systems that operate at a maximum pressure of 400 bar, the advantages of UHPLC cannot be realized worldwide. Thus, product methods developed using UHPLC capabilities cannot directly transfer these methods to receiving laboratories without qualified UHPLC availability.
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Hot Topics in HPLC Part I:This is the first in a series of articles exploring topics that will be addressed at the HPLC 2020 conference in San Diego, from June 20 to 25.
