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2017 Salary Survey: Increase in Workload, But Still OptimisticWe present our analysis of LCGC’s first reader survey on salary, workload, job satisfaction, and the job market in general. The survey shows that workloads and stress levels have increased for many. Nevertheless, most view the employment outlook as good, if not excellent, and indicate a high level of satisfaction with their present jobs.
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Real-Time Monitoring of Volatile Organic Compounds in Ambient Air Using Direct Injection Mass Spectrometry (Sept 2024)In this article, the results of a DIMS air monitoring campaign in Auckland, New Zealand, are described. Real-time SIFT–MS measurements were obtained at three sites over a period of several weeks. At each site, SIFT–MS provided effective on-site analysis to sub-ppbV levels with better than 1-min time resolution.
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High-Throughput, Routine, and Comprehensive Proteome AnalysisSee how the µPAC™ capLC LC–MS column can help increase sample throughput, and at the same time maintain the highest separation efficiency and sensitivity.
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SFC–GCxGC to Analyse Matrices from Petroleum and CoalSFC–GCxGC is shown to be useful in fossil fuel analysis. Practical examples for the analysis of complex matrices are described.
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Liquid Chromatography–Atmospheric Pressure Photoionization-Mass Spectrometry Analysis of the Nonvolatile Precursors of Rancid Smell in MayonnaiseFor lipid-containing food products like mayonnaise, determining nonvolatile lipid oxidation products, the precursor compounds for rancidity, makes it possible to predict product shelf life at an earlier stage in product development. A method based on normal-phase liquid chromatography with atmospheric pressure photoionization-mass spectrometry (LC–APPI-MS) was developed for this purpose.
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Determination of PBDEs in River Water Utilizing Automated SPE in Conformance with EU Standards at IRSAPolybrominated diphenyl ethers (PBDEs) are a worldwide contamination problem. Structurally similar to polychlorinated biphenyl (PCBs), these compounds are long-lived in the environment and can bioaccumulate throughout the food chain. The health hazards of these chemicals have attracted increasing scrutiny and, as such, a great deal of research and regulations have been implemented to manage and control them.
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Analyzing Multisegmented Block Copolymers by SEC-MALS-IV“Click” chemistry is a class of efficient and selective reactions that is characterized by quantitative yields, tolerance to a broad range of functional groups, facile experimental setup, and minimal synthetic workup. This class of reactions combines particularly well with controlled radical polymerization methods, such as atom transfer radical polymerization (ATRP), and the two techniques have been prolifically employed for the synthesis of a wide variety of novel polymeric materials, including (multi) block copolymers, stars, brushes, and gels. This note describes the analysis of multisegmented block copolymers prepared by click-coupling of block copolymers synthesized by ATRP.
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Analyzing Multisegmented Block Copolymers by SEC-MALS-IV“Click” chemistry is a class of efficient and selective reactions that is characterized by quantitative yields, tolerance to a broad range of functional groups, facile experimental setup, and minimal synthetic workup. This class of reactions combines particularly well with controlled radical polymerization methods, such as atom transfer radical polymerization (ATRP), and the two techniques have been prolifically employed for the synthesis of a wide variety of novel polymeric materials, including (multi) block copolymers, stars, brushes, and gels. This note describes the analysis of multisegmented block copolymers prepared by click-coupling of block copolymers synthesized by ATRP.
Latest:
Analyzing Multisegmented Block Copolymers by SEC-MALS-IV“Click” chemistry is a class of efficient and selective reactions that is characterized by quantitative yields, tolerance to a broad range of functional groups, facile experimental setup, and minimal synthetic workup. This class of reactions combines particularly well with controlled radical polymerization methods, such as atom transfer radical polymerization (ATRP), and the two techniques have been prolifically employed for the synthesis of a wide variety of novel polymeric materials, including (multi) block copolymers, stars, brushes, and gels. This note describes the analysis of multisegmented block copolymers prepared by click-coupling of block copolymers synthesized by ATRP.
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Simultaneous Determination of Methylxanthines and Cotinine in Human Plasma by Solid-Phase Extraction Followed by LC–MS-MSA multiresidue method has been developed and validated for the analysis of methylxanthines (caffeine and its metabolites) and cotinine in human plasma.
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Identifying "Known Unknowns" in Commercial Products by Mass SpectrometryThe identification of nontargeted species in environmental and commercial samples by mass spectrometry can be very difficult. In this article, authors from Eastman Chemical Company describe their systematic approach for the identification of nontargeted species using nominal and accurate mass data, searching both mass spectral and "spectra-less" databases.
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Recent Advances in Two-Dimensional Liquid Chromatography for Pharmaceutical and Biopharmaceutical AnalysisThis is an exciting time for 2D-LC, as the expanding community of users works to develop creative solutions involving 2D-LC to solve analytical challenges that are very difficult or impossible to solve by conventional means.
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Two-Dimensional Liquid Chromatography Does More Than Increase Peak CapacityTwo-dimensional liquid chromatography (2D-LC) is drawn out of the chromatographic toolbox if resolution for compounds of interest is insufficient. Recently, several studies have started to highlight 2D-LC as a tool of choice to streamline analytical workflows to increase automation making them less time-consuming. This article highlights two proven cases where 2D-LC does more than simply increase peak capacity.
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Analysis of PFAS in Locally Acquired Food ContainersThe combination of an untargeted approach using ultrahigh pressure liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF) and a targeted approach using UHPLC–tandem mass spectrometry (MS/MS) are presented as an ideal method for detecting per- and polyfluroalkyl substances (PFAS) in fast-food packaging.
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Separation Science in Drug Development, Part 4: Quality ControlThis fourth and last instalment in the “Separation Science in Drug Development” series provides an overview of modern practices of quality control in small-molecule drug development, including activities such as setting specifications, method validation and transfer, release and stability testing, and authoring chemistry, manufacturing, and controls (CMC) sections of regulatory filings.
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Going Beyond the Requirements of US EPA Method TO-15: Cryogen-Free Monitoring of Trace-Level “Air Toxics” at High HumidityThis study describes the gas chromatography–mass spectrometry (GC–MS) analysis of trace-level “air toxics” in humidified cannister air, using cryogen-free preconcentration technology. We show that this method is able to detect 65 target compounds ranging from propene to naphthalene, with method detection limits as low as 0.7 pptv in SIM mode, making it compliant both with standard TO-15 methods, and with “trace TO-15” methods stipulating lower detection limits.
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Application of Paper Strip Extraction in Combination with LC–MS-MS in PharmacokineticsRecent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation.
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Enhancing Peptide Mapping Sequence Coverage Through an Automated Dual Protease DigestTrypsin is one of the most commonly used proteases in peptide mapping protocols because of its high level of specificity. However, trypsin alone is not always sufficient for full sequence coverage. In this article, the authors detail how trypsin was combined with chymotrypsin to overcome this, and the benefits of an automated platform.
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15th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-15)A preview of HTC-15, which will be held at Cardiff City Hall, Cardiff, United Kingdom, from 24–26 January 2018.
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Innovations In Sample Preparation: A Virtual Symposium*Live: Friday, June 18, 2021 at 1pm BST| 8am EDT* A special one-day symposium —chaired by Jared Anderson, a key opinion leader in the field of sample preparation and a member of the LCGC’s Editorial Advisory Board (EAB) — will highlight state-of-the art advances in sample preparation and will cover a wide range of topics *On Demand Until June 18, 2022*
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Highlights from the 52nd International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2024)This “Column Watch” installment presents many of the highlighted topics and trends observed at the 52nd International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2024).
