Biological, Medical, and Clinical Analysis

Effective analysis of branched glycopeptides using porous graphite chromatography

In this review, practical principles and guidelines for designing LCxLC methods are given.

The Canadian National Research Council?s Institute for Marine Biosciences (NRC-IMB) has signed an agreement with AB SCIEX that will enable researchers worldwide to benefit from the insitute?s experience in the detection and identification of marine and freshwater biotoxins and the creation of certified reference materials.

In 1958 the University of Chicago zapped a simulated primordial earth atmosphere with a series of electrical discharges to demonstrate the way in which organic compounds may have been originally synthesized on Earth. Archived and unreported samples have recently been uncovered and submitted to modern analytical techniques, which have revealed even more abundant amino acid and amine yields than previous experiments.

Microextraction by packed sorbent is a sample preparation technique that can be connected on-line with LC or GC systems.

The ability to determine vitamin D levels in patients rapidly and reliably is a valuable tool in identification and management of treatment regimes.

The growing market for biotherapeutic peptides and the development of quantitative methods for those analytes has brought to light the challenges facing the analysis of this broad range of compounds. Market forces and regulatory requirements are encouraging analytical groups to develop methodologies that are time- and cost-effective, while still producing assays that are sensitive enough to cope with biological matrices.

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This article focuses on two of the more common techniques applied to the analysis of a series of benzodiazepines in a biological matrix.

When electrostatic effects are superimposed on hydrophilic interactions, specific functional groups can be targeted.

Agilent Technologies has announced that Merck-Serono has selected the company?s OpenLAB ELN to enhance scientific collaboration globally throughout R&D for finding new small molecules and biopharmaceuticals.

The mechanism that allows sea snails to inject their victims with paralysing venom has been uncovered by proteomic analysis of the creature?s highly specialized biology.

The advantages of HPLC-Chip-MS workflow over conventional methods of N-glycan analysis

A study into the composition of krill oil may offer new insights into the complexity of this source of omega-3.

Following the accident at Chernobyl Nuclear Power Plant in 1986, the surrounding area remains substantially contaminated with radioactive isotopes. A study into the adaptations of the surrounding plant life has suggested that the plant proteomes remain largely unchanged by the radio contamination.

A simple and rapid HPLC method was established to simultaneously determine the active ingredients of red clover.

Scientists at the Swiss Federal Institute of Technology, in collaboration with the Institute for Systems Biology in Seattle, Washington, USA, have created assays for approximately 20?000 human proteins, generating what is claimed to be the world?s first human Multiple Reaction Monitoring Atlas.

Accurate and sensitive all-ions quantification using ultra-high resolution LC-MS

Using SRM and H-SRM on an Integrated UHPLC-MS Platform for Sensitive, Accurate and Reproducible Quantification of Perfluorinated Compounds in Human Breast Milk.

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