Characterization of Monoclonal Antibodies: The Advantages of HPLC-Chip-MS Workflow over Conventional Methods of N-glycan Analysis
The advantages of HPLC-Chip-MS workflow over conventional methods of N-glycan analysis
Full characterization of mAbs is vital as the glycan moieties have such a key role in immunogenicity, effector function efficacy and drug clearance. Conventional methods of N-glycan analysis, such as LC–FLD or CE–FLD, can take two to three days to complete a single analysis. The introduction of HPLC-Chip–MS workflow systems have significantly reduced the total analysis time (including on-chip enzymatic reaction, glycan separation and MS analysis) to tens of minutes. This creates a major productivity enhancement for biopharmaceutical analysis.
RAFA 2024 Highlights: Contemporary Food Contamination Analysis Using Chromatography
November 18th 2024A series of lectures focusing on emerging analytical techniques used to analyse food contamination took place on Wednesday 6 November 2024 at RAFA 2024 in Prague, Czech Republic. The session included new approaches for analysing per- and polyfluoroalkyl substances (PFAS), polychlorinated alkanes (PCAS), Mineral Oil Hydrocarbons (MOH), and short- and medium-chain chlorinated paraffins (SCCPs and MCCPs).
Advancing Bladder Cancer Research with Mass Spectrometry: A FeMS Interview with Marta Relvas-Santos
November 12th 2024LCGC International interviewed FeMS Empowerment Award winner Marta Relvas-Santos on her use of mass spectrometry to identify potential biomarkers and therapies for bladder cancer. She also shared insights on her work with FeMS and advice for fellow scientists.
