Characterization of Monoclonal Antibodies: The Advantages of HPLC-Chip-MS Workflow over Conventional Methods of N-glycan Analysis
The advantages of HPLC-Chip-MS workflow over conventional methods of N-glycan analysis
Full characterization of mAbs is vital as the glycan moieties have such a key role in immunogenicity, effector function efficacy and drug clearance. Conventional methods of N-glycan analysis, such as LC–FLD or CE–FLD, can take two to three days to complete a single analysis. The introduction of HPLC-Chip–MS workflow systems have significantly reduced the total analysis time (including on-chip enzymatic reaction, glycan separation and MS analysis) to tens of minutes. This creates a major productivity enhancement for biopharmaceutical analysis.
GC–TOF-MS Finds 250 Volatile Compounds in E-Cigarette Liquids
November 1st 2024A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.
Green Chemistry: What is it (and What Is It Not)? And How Does It Apply to Gas Chromatography?
October 31st 2024Everyone is talking about sustainability, and organizations are creating sustainability programs. But what does green chemistry really mean, and how does it apply to gas chromatography?
AOAC International Awarded NIST Grant for Developing Drug Testing Standards
October 31st 2024The grant will be part of a new collaborative scientific initiative to address the need for standards that define the desired performance of lateral flow immunoassay test strips to detect illicit drugs in tablets and powders.
