Accurate and Sensitive All-Ions Quantification Using Ultra-High Resolution LC-MS
Accurate and sensitive all-ions quantification using ultra-high resolution LC-MS
Endogenous metabolite profiling is an extreme example of multi-component quantitative analysis. Triple quadrupole mass spectrometers are considered the gold standard for quantification using selected reaction monitoring (SRM). However, as the number of analytes increases, SRM method development becomes more labour intensive. Using shorter SRM dwell times to accommodate more components compromises sensitivity and precision. In contrast, ultra-high resolution LC–MS provides a highly sensitive and relatively unbiased quantitative assessment of metabolomics samples, without the need for MS–MS; it also obviates the need for multiple platforms for profiling and validation.
RAFA 2024 Highlights: Contemporary Food Contamination Analysis Using Chromatography
November 18th 2024A series of lectures focusing on emerging analytical techniques used to analyse food contamination took place on Wednesday 6 November 2024 at RAFA 2024 in Prague, Czech Republic. The session included new approaches for analysing per- and polyfluoroalkyl substances (PFAS), polychlorinated alkanes (PCAS), Mineral Oil Hydrocarbons (MOH), and short- and medium-chain chlorinated paraffins (SCCPs and MCCPs).
Advancing Bladder Cancer Research with Mass Spectrometry: A FeMS Interview with Marta Relvas-Santos
November 12th 2024LCGC International interviewed FeMS Empowerment Award winner Marta Relvas-Santos on her use of mass spectrometry to identify potential biomarkers and therapies for bladder cancer. She also shared insights on her work with FeMS and advice for fellow scientists.
