Using SRM and H-SRM on an Integrated UHPLC-MS Platform for Sensitive, Accurate and Reproducible Quantification of Perfluorinated Compounds in Human Breast Milk
Using SRM and H-SRM on an Integrated UHPLC-MS Platform for Sensitive, Accurate and Reproducible Quantification of Perfluorinated Compounds in Human Breast Milk.
Perfluorinated compounds (PFCs) are pollutants that bioaccumulate in animals and humans and have been linked to developmental, reproductive and systemic toxicity. PFCs are detectable in human serum and breast milk and have even been found in the blood of newborns, through lactational transfer from mothers. The potential toxicity and bioaccumulation of these chemicals has led to an increase in the need to monitor PFCs and assess their risk to humans. This article discusses how PFCs can be accurately and reproducibly detected at ppt concentrations in neat solution and human breast milk using selected reaction monitoring (SRM) and highly selective reaction monitoring (H-SRM) on an integrated ultra high performance liquid chromatography mass spectrometry (UHPLC–MS) platform.
RAFA 2024 Highlights: Contemporary Food Contamination Analysis Using Chromatography
November 18th 2024A series of lectures focusing on emerging analytical techniques used to analyse food contamination took place on Wednesday 6 November 2024 at RAFA 2024 in Prague, Czech Republic. The session included new approaches for analysing per- and polyfluoroalkyl substances (PFAS), polychlorinated alkanes (PCAS), Mineral Oil Hydrocarbons (MOH), and short- and medium-chain chlorinated paraffins (SCCPs and MCCPs).
Advancing Bladder Cancer Research with Mass Spectrometry: A FeMS Interview with Marta Relvas-Santos
November 12th 2024LCGC International interviewed FeMS Empowerment Award winner Marta Relvas-Santos on her use of mass spectrometry to identify potential biomarkers and therapies for bladder cancer. She also shared insights on her work with FeMS and advice for fellow scientists.
