Application Notes

A simple and efficient supported liquid extraction (SLE) procedure for the extraction of THC and metabolites from human plasma at low levels has been developed.

The method described employs a triple quadrupole mass spectrometer equipped with hyperbolic quadrupole rods for increased selectivity to prerform a trace level screening method for PCDD/Fs and PCBs and follows the well-established United States Environmental Protection Agency (US EPA) Method 1613A.

Tablet formulations of most major pharmaceutical drug products contain significant amounts of inactive ingredients (excipients) in their formulations.

The QuEChERS method of food sample preparation was used in conjunction with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC–TOFMS) to successfully identify PAH contaminants spiked in liquid commercial infant formula.

AGPC column and organic solvents are used to selectively pass large macro molecules such as lipids, resins, waxes, and other compounds from sample extracts while retaining the smaller target analyte molecules in the pores of the gel.

Recognition of DNAs and RNAs wide range of biological actions has driven modern biopharmaceutical research into the therapeutic value of oligonucleotides.

This rapid LC–MS method shows sensitive and selective separation of five ethanolamine analytes in wastewater.

The US Pharmacopeia recently released USP<467> as the current monograph for determining residual solvents in pharmaceutical products by static headspace.

An approach was developed to align release and end-expiry specifications for molecular size for the quality control of Merck's polyvalent pneumococcal polysaccharide vaccine (PNEUMOVAX 23).

Biodiesel fuels are part of a rapidly growing alternative fuel industry to replace gasoline with renewable, more efficient, and lower emission fuels (1).

Flexible synthetic fused silica capillary is routinely supplied to the market in long continuous lengths on low cost Styrofoam or plastic spools.

An analytical method for the rapid determination of 25-OH vitamin D2 and 25-OH vitamin D3 in serum, which will speed diagnosis of potential Vitamin D deficiencies, is described.

Organochlorine pesticides are man-made organic chemicals with a history of wide spread use in the United States, as well as globally.

Aminopolycarboxylate chelating agents form stable complexes with transition metals, thereby increasing metal solubility, preventing metal-catalyzed reactions, and removing heavy metal contamination in soil remediation.

Allantoin is a heterocyclic organic compound derived from purine.

Gelatin is the denatured form of collagen, the main component of skin, bone, and connective tissues of animals.

Clavulanic acid is commonly used in combination with penicillin and cephalosporin antibiotics to overcome bacterial resistance.

Sweeteners are low or zero-calorie sugar substitutes that are added in drinks to provide the sweet taste of sucrose or table sugar.

Many modern stationary phases suffer from poor chromatographic performance for basic compounds at low pH, especially when using low-ionic strength mobile phases such as formic acid.

Natural gas and other gaseous fuels contain varying amounts and types of sulfur compounds which can be corrosive to equipment and can inhibit or destroy gas processing catalysts.

This application note demonstrates the extraction of sour cream, cream cheese, coffee creamer, heavy whipping cream, and low fat milk using an ASE 350 Accelerated Solvent Extractor technique developed by Dionex and compares results to the traditional Mojonnier technique.

Saccharides are fundamental substances that express various bioactivities and may exist independently or form complexes with proteins or lipids.

A modified QuEChERS-type extraction method is used with an additional concentration step to detect 38 anthelmintic (nematicides, flukicides, endectocides) drug residues, consisting of benzimidazoles, avermectins, and flukicides in milk. UHPLC–MS-MS instrumentation detects most analytes at <1 µg/kg.

Nicotine is a famously addictive alkaloid found in tobacco. Controlled doses of nicotine compounds are sometimes used to help tobacco users quit smoking.

Perfluorinated compounds (PFC) are considered as emerging contaminants that attract high interest from the international scientific community.

Using a bonded polymeric zwitterionic stationary phase, in HILIC mode, polar quaternary herbicides like Diquat can easily be retained, with good peak symmetry.

Since the gas flow required for the separation step in gas chromatography is frequently lower that that required to optimize the detection, nitrogen is used as a make-up gas to increase the gas flow for detection.

Rapid Resolution High Definition (RRHD) columns, used on UHPLC instruments, provide significant productivity enhancements because they are stable to 1200 bar and can withstand higher flow rates.

Pesticide pollution is a subject of global concern, and although many countries have now banned the use of organochlorine pesticides, they linger in the environment and can contaminate water sources.

With Americans becoming increasingly health conscious and concerned with their exposure to chemicals, businesses have made movements to create more products that are safer for the consumer and the environment.