Application Notes

Flexible synthetic fused silica capillary is routinely supplied to the market in long continuous lengths on low cost Styrofoam or plastic spools.

An analytical method for the rapid determination of 25-OH vitamin D2 and 25-OH vitamin D3 in serum, which will speed diagnosis of potential Vitamin D deficiencies, is described.

Organochlorine pesticides are man-made organic chemicals with a history of wide spread use in the United States, as well as globally.

Aminopolycarboxylate chelating agents form stable complexes with transition metals, thereby increasing metal solubility, preventing metal-catalyzed reactions, and removing heavy metal contamination in soil remediation.

Allantoin is a heterocyclic organic compound derived from purine.

Gelatin is the denatured form of collagen, the main component of skin, bone, and connective tissues of animals.

Clavulanic acid is commonly used in combination with penicillin and cephalosporin antibiotics to overcome bacterial resistance.

Sweeteners are low or zero-calorie sugar substitutes that are added in drinks to provide the sweet taste of sucrose or table sugar.

Many modern stationary phases suffer from poor chromatographic performance for basic compounds at low pH, especially when using low-ionic strength mobile phases such as formic acid.

Natural gas and other gaseous fuels contain varying amounts and types of sulfur compounds which can be corrosive to equipment and can inhibit or destroy gas processing catalysts.

This application note demonstrates the extraction of sour cream, cream cheese, coffee creamer, heavy whipping cream, and low fat milk using an ASE 350 Accelerated Solvent Extractor technique developed by Dionex and compares results to the traditional Mojonnier technique.

Saccharides are fundamental substances that express various bioactivities and may exist independently or form complexes with proteins or lipids.

A modified QuEChERS-type extraction method is used with an additional concentration step to detect 38 anthelmintic (nematicides, flukicides, endectocides) drug residues, consisting of benzimidazoles, avermectins, and flukicides in milk. UHPLC–MS-MS instrumentation detects most analytes at <1 µg/kg.

Nicotine is a famously addictive alkaloid found in tobacco. Controlled doses of nicotine compounds are sometimes used to help tobacco users quit smoking.

Perfluorinated compounds (PFC) are considered as emerging contaminants that attract high interest from the international scientific community.

Using a bonded polymeric zwitterionic stationary phase, in HILIC mode, polar quaternary herbicides like Diquat can easily be retained, with good peak symmetry.

Since the gas flow required for the separation step in gas chromatography is frequently lower that that required to optimize the detection, nitrogen is used as a make-up gas to increase the gas flow for detection.

Rapid Resolution High Definition (RRHD) columns, used on UHPLC instruments, provide significant productivity enhancements because they are stable to 1200 bar and can withstand higher flow rates.

Pesticide pollution is a subject of global concern, and although many countries have now banned the use of organochlorine pesticides, they linger in the environment and can contaminate water sources.

With Americans becoming increasingly health conscious and concerned with their exposure to chemicals, businesses have made movements to create more products that are safer for the consumer and the environment.

The separation of closely related compounds is of interest to many disciplines including natural products, flavors and fragrances, and pharmaceuticals.

The determination of enantiomeric purity is crucial in new drug development.

New efficient, effective, and sensitive sample preparation application for the extraction of ethyl glucuronide from human urine at significantly low levels using EVOLUTE AX; a resin-based mixed-mode sorbent with an optimised combination of nonpolar (hydrophobic), polar (hydrophilic), and strong anion exchange interactions.

Aflatoxins occur naturally in peanuts, cottonseed, corn, and dried chili pepper, as well as many mixed or processed foods and feeds.

This article describes a straightforward ion chromatographic method that uses isocratic elution and pulsed amperometric detection (PAD) to sensitively determine water-soluble polyols and sugar alcohols as well as mono-, di- and oligosaccharides in essential and nonessential foodstuffs.

In food, organic acids originate from the natural biochemistry processes or are added as preservatives, acidulants and stabilizers.

Using a bonded polymeric zwitterionic stationary phase, in HILIC mode, polar quaternary herbicides like Diquat can easily be retained, with good peak symmetry.

Naringenin, a chiral flavonoid found in several fruit juices, is well known for its beneficial health-related properties, including antioxidant, antimicrobial, anti-inflammatory, and immunomodulating activities. The HPLC and supercritical fluid chromatography (SFC) enantioselective separation of (R,S)-Naringenin has been performed on both analytical and semi-preparative scale using an amylose derived RegisPack CSP.

Isolation and purification of compounds and their impurities/degradants is an important part of the drug discovery and development process.

Polysaccharides are often separated using SEC columns. However, SEC columns do have limitations, specifically: poor column efficiency or peak shape.