Application Notes

Burning mosquito coils to repel these pests is common in many countries; however the emission of various, potentially toxic volatile organic compounds (VOCs) is cause for concern.

N-Nitrosodimethylamine and other structurally similar nitrosamines are classified as probable carcinogens by the U.S. EPA, and their presence has been reported in California drinking water since 1998.

Levoglucosan is a combustion product of cellulose and, as such, widely used as a unique tracer for biomass burning sources in atmospheric aerosols.

Agilent Poroshell 120, a superficially porous particle column, offers resolution and speed similar to columns packed with 1.8-µm totally porous particles, without generating high back pressure.

Gel filtration chromatography is the primary method used to analyze the amount of aggregate and dimer present in a therapeutic protein sample.

This paper describes the use of the AB SCIEX TripleTOFTM 5600 LC–MS-MS system for targeted and nontargeted screening for pesticide residue in food samples.

Fast, flexible platforms for peptide quantification are needed, particularly for a discovery setting.

The optical isomers of flavanone have been separated using the EpitomizeTM CSP-1 series of chiral stationary phases.

This article reports a new sample injection mechanism for an autosampler that directly transfers a sample to column without passing it through any flow-changing device, and hence minimizes a delay volume and reduces a carryover signal to the extreme level.

In this application note we present an online SPE-LC method for the determination of trace-level endocrine disruptive compounds (EDCs) in seawater using the new SolEx HRP cartridge as the solid-phase extraction (SPE) phase.

A sample of ambient cabin air from a commercial airliner was collected by stir bar sorption extraction (SBSE) and analyzed by thermal desorption GCxGC-TOFMS.

The new MAbPacTM size exclusion (SEC) column is based on high-purity, spherical, porous (300 Å), 5 µm silica covalently modified with a proprietary diol hydrophilic layer.

Site-specific analysis of protein glycosylation has become a very important issue in pharmaceutical/biotech industries, requiring specific analytical tools and methodologies.

Urine is often used to analyze drugs of abuse because it is easy to collect and is available in copious amounts.

Aflatoxins occur naturally in peanuts, cottonseed, corn, and dried chili pepper, as well as many mixed or processed foods and feeds.

Method development in reversed-phase liquid chromatography (RPLC) can be challenging for structurally similar compounds.

Electrochemical detection (ECD) is both selective and extremely sensitive. However, relatively few compounds are electrochemically active, therefore limiting its application.

Complete high resolution cross-fractionation of Polyolefins in the molar mass and composition dimensions is achieved with a new benchtop CFC analytical instrument.

Methods: Vials and closures were exposed to acetonitrile for 2 h and subsequently analysed by LC-UV, LC–MS, and GC–MS to characterize the interferences.

Whisky is a complex and variable material, the quality of which is affected by the raw materials and processing.

Gel-permeation chromatography (GPC) is a highly effective postextraction cleanup method for removing high molecular-weight interferences such as lipids, proteins, and pigments from sample extracts prior to analysis.

P-hydroxybenzoic acid esters, also called parabens, are widely used as antimicrobial preservatives in cosmetic products.

Modern analytical applications often demand definitive tandem MS results on ever more complex samples utilizing fast separation techniques.

The QuEChERS approach is used for the extraction of 16 PAH compounds from fish with analysis by LC using fluorescence detection.

Since the addition of electron transfer dissociation (ETD) to the Thermo Scientific LTQ Orbitrap hybrid mass spectrometers, ETD has become a standard tool for proteomics research together with the traditional collision-induced dissociation (CID) (1).

For many years, the use of guard columns has been advocated by column manufacturers and other experts to protect and extend column lifetime and performance of analytical columns from potential damage caused by the presence of chemical contaminants and microparticulates in the sample and mobile phase.

The fully automated combustion ion chromatography (CIC) system presented here combines a highly efficient combustion system with the separation power of ion chromatography (IC). CIC allows for the simultaneous, speciated trace analysis of halide (F, Cl, Br and I) and sulphur compounds (as sulphate) from sub-ppm to percent levels in any nonaqueous sample matrix.

Analysis of biological samples frequently involves the identification of peptides from low amounts of complex samples. Confident identification of these peptides requires rapid generation of high quality, high sensitivity MS and MS–MS data. The maXis TOF mass spectrometer incorporates novel technical innovations, which together produce an unprecedented level of data quality, resulting in a significant increase in the number of peptides identified from challenging samples.

Phenol formaldehyde resins are formed by a step-growth polymerization. GPC/SEC with RI and UV detection is often used to characterize resins and to quantify the amount of different oligomeric species.

Ingestion of DEG-adulterated glycerin excipients in pharmaceuticals and personal care products, such as toothpaste, mouth wash and medicinal syrups has caused systemic alcohol intoxication, acidosis and subsequent multiorgan failure that have led to hundreds of fatalities of children and adults.