Ion Chromatography

A new published study introduces a simple and fast way to differentiate between animal species based on their hair. The in-sample digestion method coupled with mass spectrometry analysis was successfully tested on multiple species.

A new study has identified potential quality-markers for Eucommiae Folium (Duzhongye), a traditional Chinese medicine, using UHPLC–MS/MS analysis, and has recommended isoquercitrin as a new quality-marker candidate.

A new approach for identifying isomeric and isobaric metabolites has been developed using liquid chromatography (LC) with high-resolution ion mobility spectrometry (IMS) and cryogenic infrared (IR) spectroscopy, allowing for faster, more accurate, and cost-effective metabolomics workflows.

A new study analyzed the trophic niches and niche overlap between native and introduced cyprinid fishes in Karacaören I reservoir using IRMS.

Researchers have shown the effectiveness of ion chromatography (IC) in identifying markers of forest fire emissions in rainfall samples, providing valuable insights into the signature of forest fire emissions and aiding in the development of models to predict and control air pollution resulting from these events.

Recent advancements in electrospray ionization mass spectrometry (ESI-MS) for single-cell proteomics are highlighted in a review article, including various separation techniques and MS instrumentation used to improve sample throughput and coverage.

New article reviews the progress in suppression techniques for ion chromatography from 1981 to 2022, with an emphasis on the last ten years, and discusses the current challenges and future prospects regarding suppressors.

A new study evaluated the use of HILIC for fast aqueous species distribution analysis of Nickel(II)-Histidine complex, finding that HILIC is appropriate for investigating coordination metal complexes.

A desorption electrospray ionization mass spectrometry (DESI-MS) method has been developed to effectively analyze historical synthetic dye samples.

A recent study analyzed individual hippocampal cells at ultrahigh mass resolution using a FT-ICR mass spectrometer.

Carol V. Robinson of the University of Oxford has been named the 2023 recipient of the ASMS John B. Fenn Award for Distinguished Contribution in Mass Spectrometry. Robinson will receive the award at the 2023 ASMS Conference in Houston, Texas, which takes place June 4–8.

A new study tested different solvents and buffer additives for ion mobility spectrometry to test their impact on results.

Scientists have discovered that combining imaging mass spectrometry and microscopy can enhance molecular visualization.

Ion chromatography is a technique best suited for analyzing herbicides, such as glyphosate, because it can detect its metabolites with high sensitivity, selectivity, and accuracy.

Chemical isotope labeling (CIL) can lead to excellent biological sample analysis when combined with mass spectrometry (MS).

Direct-infusion tandem mass spectrometry (DI-MS/MS) enables researchers to quantify citrate isomers and isobars in biological samples with high accuracy and reliability.

Scientists recently used continuous electrospray ionization mass spectrometry to study what makes the inland taipei snake venom so dangerous.

A new way to control ion transports in microfluidic systems has the potential to improve the technology and expand applications.

A new differential ion mobility spectrometry device has been created that will greatly change how chemicals and substances are found and analyzed.

A recent study highlights the challenges and triumphs scientists studying charge determination mass spectrometry faced in the mid-1990s.

SIFT–MS analysis has potential to screen large numbers of packaging samples for the volatile MOH fraction, providing a rapid indication of packaging material contamination.

Pressure-enhanced liquid chromatography (PE-LC) offers a new approach for improving selectivity for large molecule separations. Examples shown here include short oligonucleotides in ion-pairing reversed-phase (IP-RP) liquid chromatography and larger nucleic acids in ion-exchange (IEX) chromatography.

Analysis of unidentified organofluorine compounds and known PFAS in environmental and human samples presents many challenges. Combustion ion chromatography is one technique that can help.

Using Earth as a figurative analogy, we explore the merits of flexibility when considering which liquid chromatography (LC) modality to use for any particular bioanalysis.

Interest in three-dimensional (3D) printing technology is expanding rapidly. What impact can it have in mass spectrometry? Robert Winkler, of the Center for Research and Advanced Studies Irapuato, in Guanajuato, Mexico, is exploring this question. We recently spoke with Prof. Winkler about this work.

Modern ion mobility–mass spectrometry (IM–MS) is a key separation technology for detailed molecular characterization studies and also as part of emerging data acquisition strategies for demanding small molecule and several applications. Here is what you need to know.

Using ion mobility, analytes that have the same molecular mass can be separated by their shape, centers of mass, and collision cross section, but challenges such as ion loss can still occur. A new development in ion mobility separation, high-resolution ion mobility (HRIM), addresses such problems, and is particularly well suited to challenging applications, such as glycosylation monitoring of biological drugs and vitamin D analysis.

Ion-exchange chromatography (IEX) is a frequently overlooked technique. This novel IEX method uses non-aqueous mobile phases to purify a non-crystalline intermediate after a reductive amination with D-xylose. IEX delivers a step change in strength and purity of the intermediate allowing successful downstream processing.

Sulphite is a preservative added to a vast range of foods and beverages to prevent browning or oxidation. Some individuals are sensitive to sulphite additives and may experience a range of allergic reactions. Therefore, both the U.S. Food and Drug Administration (FDA) and European Union (EU) laws require that the presence of sulphites be declared on food labels when the concentration exceeds 10 mg/L. Several analytical methods exist to measure sulphite in food and beverages, however, they suffer from repeatability issues, and can be quite cumbersome to perform. A patent has been filed for an innovative, fast, and accurate ion chromatographic (IC) method based on direct current (DC) mode electrochemical detection. This article explains more.