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Strategies for the Quantification of Endogenously Present Small Molecules in Biological SamplesThe main objective of this review article is to provide a clear summary of the different methods that can be used to quantify endogenous small molecules. Because of the increased use of mass spectrometry (MS) in the field of bioanalysis, a special focus will be placed on quantification by liquid chromatography (LC)–MS. Practical recommendations to face this bioanalytical challenge, in particular in terms of method validation, will also be provided.
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Strategies for the Quantification of Endogenously Present Small Molecules in Biological SamplesThe main objective of this review article is to provide a clear summary of the different methods that can be used to quantify endogenous small molecules. Because of the increased use of mass spectrometry (MS) in the field of bioanalysis, a special focus will be placed on quantification by liquid chromatography (LC)–MS. Practical recommendations to face this bioanalytical challenge, in particular in terms of method validation, will also be provided.
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Mobile Phase Buffers in LC: Effect of Buffer Preparation Method on Retention RepeatabilityFor liquid chromatography (LC) methods where the buffer pH and composition have an influence on retention, which buffer preparation method will provide the most repeatable results?
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Sample Treatment in Routine Analysis: A Case Study: Sulphonamides in LiverCurrently, sample treatment is still the bottleneck in the development of analytical methods to analyze complex samples, especially for routine analysis where high-tech instruments are not always available. Research on the evaluation of different sample treatments is needed to achieve the sensitivity and selectivity required. This article presents a case study related to the determination of sulphonamides in liver. Different extraction strategies, including solid-liquid extraction (SLE), ultrasound-assisted extraction (UAE), and solid-phase extraction (SPE), were evaluated to produce a simple and effective extraction method.
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Sample Treatment in Routine Analysis: A Case Study: Sulphonamides in LiverCurrently, sample treatment is still the bottleneck in the development of analytical methods to analyze complex samples, especially for routine analysis where high-tech instruments are not always available. Research on the evaluation of different sample treatments is needed to achieve the sensitivity and selectivity required. This article presents a case study related to the determination of sulphonamides in liver. Different extraction strategies, including solid-liquid extraction (SLE), ultrasound-assisted extraction (UAE), and solid-phase extraction (SPE), were evaluated to produce a simple and effective extraction method.
Latest:
Sample Treatment in Routine Analysis: A Case Study: Sulphonamides in LiverCurrently, sample treatment is still the bottleneck in the development of analytical methods to analyze complex samples, especially for routine analysis where high-tech instruments are not always available. Research on the evaluation of different sample treatments is needed to achieve the sensitivity and selectivity required. This article presents a case study related to the determination of sulphonamides in liver. Different extraction strategies, including solid-liquid extraction (SLE), ultrasound-assisted extraction (UAE), and solid-phase extraction (SPE), were evaluated to produce a simple and effective extraction method.
Latest:
Sample Treatment in Routine Analysis: A Case Study: Sulphonamides in LiverCurrently, sample treatment is still the bottleneck in the development of analytical methods to analyze complex samples, especially for routine analysis where high-tech instruments are not always available. Research on the evaluation of different sample treatments is needed to achieve the sensitivity and selectivity required. This article presents a case study related to the determination of sulphonamides in liver. Different extraction strategies, including solid-liquid extraction (SLE), ultrasound-assisted extraction (UAE), and solid-phase extraction (SPE), were evaluated to produce a simple and effective extraction method.
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A Whole Lot of Data Going On Book Review: Data Integrity and Data Governance by R.D. McDowallR.D. McDowall has written an excellent book on data integrity and data governance. Those who need to understand what this is should read the book and follow his advice. He has included both what the regulations and regulators say and what we need to do to be in compliance. This is a scalable approach with enhancements for larger items and shortcuts for smaller items, with numerous examples throughout the book.
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Analysis of Active Cannabis Compounds in Edible Food Products: Gummy Bears and BrowniesPotency testing in marijuana-infused edibles is a problematic task due to the complexity of the matrices. The concentration of active ingredients in edibles can range from a few ppm to 3.5% (1). In this application, active cannabinoid compounds were extracted from gummy bears (and also brownies, results not shown), followed by HPLC analysis.
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Optimizing the Use of High Purity Water in Ion Chromatography – Direct-Feed and Hints and TipsAs instrumentation and analytical methods are becoming increasingly sensitive, the ability to perform trace and ultra trace analyses relies on the high quality and purity of the reagents used.
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Determination of Psilocin and Psilocybin in Magic Mushrooms Using iHILIC®-Fusion and MSHallucinogenic mushrooms, known as magic mushrooms, contain psychoactive compounds such as psilocin and psilocybin (Figure 1). This hallucinogenic effect means they are constantly offered on the black market. Therefore, the reliable quantification of these compounds is a particularly important task for forensic analysis because their results have a significant impact on the judgement passed by the courts.
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Determination of Psilocin and Psilocybin in Magic Mushrooms Using iHILIC®-Fusion and MSHallucinogenic mushrooms, known as magic mushrooms, contain psychoactive compounds such as psilocin and psilocybin (Figure 1). This hallucinogenic effect means they are constantly offered on the black market. Therefore, the reliable quantification of these compounds is a particularly important task for forensic analysis because their results have a significant impact on the judgement passed by the courts.
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Determination of Psilocin and Psilocybin in Magic Mushrooms Using iHILIC®-Fusion and MSHallucinogenic mushrooms, known as magic mushrooms, contain psychoactive compounds such as psilocin and psilocybin (Figure 1). This hallucinogenic effect means they are constantly offered on the black market. Therefore, the reliable quantification of these compounds is a particularly important task for forensic analysis because their results have a significant impact on the judgement passed by the courts.
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The 30th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2019)A preview of the upcoming 30th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2019), which is due to be held on 15–18 September 2019 at the Convention Centre of The Dan Panorama Hotel in Tel Aviv, Israel.
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Gulf Coast Conference Continues to Transform the Analytical WorldThe Gulf Coast Conference (GCC) is held in Galveston annually. For the past 50+ years, this gathering of international scientists has blazed a trail for analytical needs and innovations for the refining and petrochemical industries.
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Multi-Attribute Analysis of Monoclonal AntibodiesMulti-attribute analysis combines protein A affinity chromatography, SEC, and LC/MS in a 3D setup for assessment of features including mAb titer and size variants.
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Direct Analysis of Drugs in BiofluidsSample pretreatment is often a time consuming and labor-intensive step which can be a restricting factor for the rapid analysis. This is especially true for the analysis of drugs in biofluids containing many interfering matrices.
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A Convenient Alternative to MALDI and ESIIonization of small, large, volatile, and nonvolatile compounds with charge states nearly identical to electrospray ionization are produced from a solid matrix or solution with high sensitivity utilizing the vacuum inherent with any mass spectrometer. With the proper matrix, analytes can be analyzed from ambient conditions or by direct introduction into vacuum.
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The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
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The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
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The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
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The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
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The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
Latest:
The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
Latest:
The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by Liquid Chromatography–MS/MS and Gas Chromatography–MS/MSAn increasing range of per- and polyfluoroalkyl substances (PFAS) has been found migrating from food contact material into food. This article establishes an integrated analytical approach combining HPLC–MS/MS and GC–MS/MS to detect 36 such PFAS.
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Simultaneous Determination of Methylxanthines and Cotinine in Human Plasma by Solid-Phase Extraction Followed by LC–MS-MSA multiresidue method has been developed and validated for the analysis of methylxanthines (caffeine and its metabolites) and cotinine in human plasma.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
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Laser Thermal Desorption and GC×GC for Harsh Environment and Planetary Mass SpectrometryThe development of analytical instrumentation for harsh terrestrial environments and outer planet space exploration exponentially increases instrument requirements-for features such as robustness, autonomous operation, and speed-and poses unique system integration challenges. Here, we explore the use of laser thermal desorption coupled to comprehensive two-dimensional gas chromatography (LTD-GC×GC) for use with a compact, high-resolution mass spectrometer for challenging applications.
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High-Throughput Experimentation: Where Does Mass Spectrometry Fit?In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.
