Sample Preparation

This article focuses on two of the more common techniques applied to the analysis of a series of benzodiazepines in a biological matrix.

An introduction to sequential injection analysis as a useful tool for automated sample preparation.

A multistep workflow process provides purified samples for in-vitro testing in just two or three business days.

High recovery, reproducibility, and cost savings are among the advantages of this environmentally friendly method.

Miniaturization and solvent substitution are two key approaches.

How to measure a method's 'greenness' and examples of green chromatography in action.

When electrostatic effects are superimposed on hydrophilic interactions, specific functional groups can be targeted.

New methods are available for whole blood analysis. Here, various approaches are compared and contrasted.

Ways of improving laboratory practices by introducing an effective sample preparation protocol into current workflow systems

Industry veteran Thomas Beesley takes readers on a tour of his experiences in chromatography.

The analysis of clozapine and norclozapine in plasma using automated on-line sample preparation and LC–MS/MS

In this installment, the subject of LPME is reviewed, with emphasis on the use of hollow fibers.

Discussing trends in sample preparation for the determination of phytochemicals in natural products.

The inventors of the QuEChERS technique present an update and a look at the future.

Selected modes of operations are presented and a few recent environmental applications of modular PLE are reviewed.

Selected modes of operations are presented and a few recent environmental applications of modular PLE are reviewed.

Associate Editor Megan Evans reviews this year's ASMS Conference, held in Salt Lake City, Utah.

Speaking about studies into electromembrane extraction and the possibilities that this alternative sample preparation technique opens up for research.

Ron Majors presents the second part of his yearly review of all that was new and innovative at Pittcon 2010, held this year in Orlando, Florida.

How the combination of an electroextraction with hollow-fiber liquid-phase microextraction can lead to a selective, rapid new method.

This article provides an introduction to electrochemical liquid chromatography mass spectrometry. The instrumental set-up is presented and selected applications in drug development processes are discussed.

The technique can be seen as an alternative to size-exclusion chromatography. This article illustrates how to choose parameters such as the dimensions of the separation channel and flow rates.

LCGC provides its annual editorial index as a resource for readers.

Peter Johnson gives readers the history of the well-known Minnesota Chromatography Forum.

In this installment of "MS-The Practical Art," guest columnist Jack Henion presents an historical and practical overview of lab-on-a-chip (LOC) research and the commercial achievement associated with it so far.

To meet system suitability requirements, chromatographers might need to make adjustments to the high performance liquid chromatography (HPLC) operating conditions.

Incognito presents the first in a series on the pitfalls in the practice of modern SPE.

Ron Majors provides first-hand coverage of some of the technology and application advances reported at HPLC 2009.

The former "Milestones in Chromatography" editor returns to give readers the story of his time in the field.

Ron Majors discusses the technique of Salting-out Liquid-Liquid Extraction (SALLE) and provides some examples of its successful applications.