The Partition Coefficient (log P), Distribution Coefficient (log D) and Acid Dissociation Constant (pKa): Knowing Your Compound for Solid-Phase Extraction Method Development in Reversed-Phase Mode
Gathering information about the chemical and physical properties of target analytes is an essential step to effective solid-phase extraction (SPE) method development.
Gathering information about the chemical and physical properties of target analytes is an essential step to effective solid-phase extraction (SPE) method development. Log P, log D and pKa are key analyte characteristics that can have a significant impact on the rapid success of reversed-phase SPE method development. This article explores the value of these chemical properties and demonstrates their importance in efficient reversed-phase SPE method development and optimization.
RAFA 2024 Highlights: Contemporary Food Contamination Analysis Using Chromatography
November 18th 2024A series of lectures focusing on emerging analytical techniques used to analyse food contamination took place on Wednesday 6 November 2024 at RAFA 2024 in Prague, Czech Republic. The session included new approaches for analysing per- and polyfluoroalkyl substances (PFAS), polychlorinated alkanes (PCAS), Mineral Oil Hydrocarbons (MOH), and short- and medium-chain chlorinated paraffins (SCCPs and MCCPs).
