November 11th 2024
Pharmaceutical excipients, such as polyethylene glycol-based polymers, must be tested for the presence of ethylene oxide (EtO) and 1,4-dioxane as part of a safety assessment, according to USP Chapter <228>.
Self-Cleaning LC–MS in Organoid/Organ-on-Chip Systems for Small Molecule Analysis
August 7th 2024Steven Ray Wilson and Hanne Røberg-Larsen of the University of Oslo recently discussed the practical application and advantages of their FDA-validated research to analyse small molecule drugs and their metabolites in organoid/organ-on-chip systems that serve as alternatives to animal models.
Characterization of Product Related Variants in Therapeutic Monoclonal Antibodies
July 16th 2024Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.
Monitoring 5-Fluorouracil Levels in Dried Blood Spots with UHPLC-MS/MS
May 3rd 2024Researchers have utilized ultra-high performance liquid chromatography-tandem mass spectrometry (UH PLC-MS/MS) to monitor 5-Fluorouracil, a medication used to treat various cancers, in dried blood spots. This process offers a simpler, more efficient method than those in place involving the monitoring of plasma.
Metabolomics Meets Machine Learning: The Future of Nature-Inspired Drug Discovery
March 29th 2024Researchers at Enveda Biosciences are transforming nature into new medicines with their artificial intelligence (AI)-enabled industrial-scale drug discovery platform incorporating tandem mass spectrometry (MS/MS).
Element Launches New Pharmaceutical Testing Service
March 29th 2024Element Materials Technology introduced its Rapid Response Pharmaceutical Testing Service, providing expedited testing and focusing on various requirements including active ingredients and final drug products, extractables and leachables, degradation production, and elemental impurities.
Advanced Microextraction Technique Enhances Barbiturate Detection in Serum Samples
November 13th 2023In this study, an efficient technique is described for extracting and quantifying barbiturates in serum samples, combining ultrasound and surfactant-assisted dispersive liquid–liquid microextraction (dLLME) with poly(ethylene oxide)-mediated stacking in capillary electrophoresis.