Chromatographic Strategies for Intact mAb and ADC Analysis

This webinar will focus on advanced techniques and strategies for analyzing intact monoclonal antibodies and antibody-drug conjugates. Multiple chromatography techniques and detection methods will be discussed to address select critical quality attributes investigated during biotherapeutic characterization.

Register Free: https://www.chromatographyonline.com/lcgc_w/chromatographic-strategies

Event Overview:

Various advanced chromatographic techniques and detection methods will be described for the analysis of intact monoclonal antibodies (mAbs) and antibody-drug conjugates (ADC) in this webinar. Topics addressed will include fundamentals and example methods utilizing size exclusion (SEC), affinity, and hydrophobic interaction chromatography (HIC) to determine various structural aspects of intact mAbs and ADCs. Select strategies will be discussed to make SEC and affinity chromatography amenable for advanced detection technologies like native mass spectrometry and multi-angle light scattering. Stationary phase selections for HIC will be briefly addressed for separations related to drug-to-antibody ratios for ADCs.

Key Learning Objectives:

• Selecting and understanding the importance of phase chemistry and particle morphology in biomolecule analysis
• Understanding best practices for selecting appropriate mobile phase systems for each chromatography mode
• Diagnosing the root causes of issues encountered when troubleshooting biomolecule separations

Who Should Attend:

• Antibody characterization scientists
• BioPharma R&D scientists
• Analytical development chemists
• Quality control analysts
• Biotherapeutics discovery scientists

Speaker:

Corey Meadows, PhD
Regional Product Specialist
Tosoh Bioscience LLC

Corey Meadows, PhD obtained his degree in physical chemistry at University of California, Berkeley in 2014. He served as an analytical development scientist in the renewables and biopharmaceutical industries, with a focus on HPLC, LC-MS, and GC-MS techniques for small and large molecule analyses. While working within the biopharmaceutical industry, he focused primarily on antibody and protein therapeutic characterization using high resolution UPLC-MS methods. As a regional product specialist at Tosoh Bioscience, Meadows focuses on application support and product development for analytical columns and multiangle light scattering detectors.

Register Free: https://www.chromatographyonline.com/lcgc_w/chromatographic-strategies