Multidimensional GC

Invented by J. Phillips in 1989, comprehensive GCXGC has strong chromatographic resolving power; from its original petrochemical applications it has been extended to many others. However, coelutions with matrix peaks are often observed and a higher separation power is required.

One fast, simple QuEChERS extraction for a broad range of pesticides.

An excerpt from LCGC's e-learning tutorial on multidimensional GC at CHROMacademy.com.

Achieving efficient analyte transfer between columns is critical to gaining the benefits of multidimensional GC.

An excerpt from LCGC's e-learning tutorial on HPLC on multidimensional GC at Chromacademy.com.

Comprehensive GCÃ-GC(qMS) provides a maximum chromatographic separation power in gas chromatography (GC). Combining it with the highly selective negative chemical ionization (NCI) mode gives highest sensitivity for electrophilic molecules like trichloroanisole and tribromoanisole.

The International Symposium on Capillary Chromatography (ISCC) has established its reputation as forum for microcolumn separation techniques and, over the years, the most important developments in capillary gas chromatography, microcolumn liquid chromatography and electromigration techniques have been presented in this symposium series.

GCxGC-TOFMS provided a comprehensive analysis of tobacco smoke. Individual smoke constituents across several target compound classes were extracted, chromatographically resolved, then identified and quantified with mass spectral detection.

Analysis of natural compounds is becoming increasingly important. One thriving area is the evaluation and application of environmental biopolymers, such as humic substances (HSs) in various applications, including medicine, industry, agriculture and environmental protection.

Describes a novel approach for the enantioselective separation of spearmint oil incorporating a fluidic modulation system.

SFC–GCxGC is shown to be useful in fossil fuel analysis. Practical examples for the analysis of complex matrices are described.

Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.

Slides to accompany the vidcast interview from Pittcon 2011 with Luigi Mondello, Professor, Analytical Chemistry, School of Pharmacy, University of Messina

Slides to accompany the vidcast interview from Pittcon 2011 with Luigi Mondello, Professor, Analytical Chemistry, School of Pharmacy, University of Messina

Luigi Mondello, University of Messina

The QuEChERS method of food sample preparation was used in conjunction with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC–TOFMS) to successfully identify PAH contaminants spiked in liquid commercial infant formula.

LECO Application Note

In this study, comprehensive 2D gas chromatography-mass spectrometry with electron impact and chemical ionization was used to characterize silylated fatty alcohol alkoxylates.

Exploring the use of GCxGC-FID as a technique for qualitative and quantitative analysis of perfumes

The GC×GC-7 symposium ran concurrently with this year?s ISCC in Riva del Garda, Italy. Speaking with The Column, Philip Marriott of the Australian Centre for Research on Separation Science, RMIT, Melbourne, Australia, said it ?offered the most comprehensive and thorough GCxGC programme yet assembled.?

Comprehensive two dimensional gas chromatography–mass spectrometry is a powerful method to identify target analytes in complex matrices. An example is shown of identification of pesticides in citrus oil.

Coelutions using one dimensional chromatography are often observed in flavour and fragrance analysis.

The misuse of androgenic anabolic steroids in sports was banned in 1976 by the International Olympic Committee and global sports community. The illegal use of anabolic steroids has reached disturbing levels worldwide. This worldwide problem is fueled partially by an ever-increasing demand for better athletic performance. The World Anti-Doping Agency has formulated strict guidelines for minimum allowable concentrations of exogenous anabolic steroids and their metabolites. The standard test methods for doping control are analyzed in urine samples with trimethyl-silyl derivatization. Urine is a complex and difficult biological matrix. This research shows the advantages of using comprehensive two-dimensional gas chromatography–time-of-flight-mass spectrometry (GCÃ-GC–TOF-MS) and illustrates the capability of GCÃ-GC-TOF-MS to be an effective instrumental option for antidoping control screening.

In this article, the combination of SPME with GCxGC and GCxGC–TOF-MS is discussed using mixtures of solvents as example analytes

Retention Times of 209 PCB Congeners Using GCxGC-TOFMS - LECO apps note

Demonstrating the suitability of a new wax stationary phase for GCxGC analysis of essential oils

Design of a FID/MS Splitting for MS Detection in The First and Second Dimension of a Multidimensional GC–MS System

Why is thermal modulation more widely discussed than flow modulation in comprehensive multidimensional gas chromatography?

This article discusses the unique properties of ILs and their potential impact as GC stationary phases.