Non-targeted Cross-Sample Analysis with Comprehensive Two-Dimensional Gas Chromatography (GC×GC)
Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.
The goal of non-targeted cross-sample analysis is to discover salient chemical characteristics from multiple samples. Applications of non-targeted cross-sample analysis include sample classification, quality control, chemical fingerprinting and biomarker discovery. Non-targeted cross-sample analysis should distinguish and reliably characterize all chemical constituents in each sample, correctly match the corresponding features that characterize each constituent in different samples, and recognize the most significant characteristics or patterns between or among samples. Comprehensive two‑dimensional gas chromatography (GC×GC) is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis. GC×GC data is information-rich but is also large and complex, making the analytical tasks of extracting and matching features and then recognizing salient patterns challenging. This review surveys some of the varied approaches that researchers have applied to these difficult problems.
Analysis of Pesticides in Foods Using GC–MS/MS: An Interview with José Fernando Huertas-Pérez
December 16th 2024In this LCGC International interview with José Fernando Huertas-Pérez who is a specialist in chemical contaminants analytics and mitigation at the Nestlé Institute for Food Safety and Analytical Sciences at Nestlé Research in Switzerland, In this interview we discuss his recent research work published in Food Chemistry on the subject of a method for quantifying multi-residue pesticides in food matrices using gas chromatography–tandem mass spectrometry (GC–MS/MS) (1).
The Use of SPME and GC×GC in Food Analysis: An Interview with Giorgia Purcaro
December 16th 2024LCGC International sat down with Giorgia Purcaro of the University of Liege to discuss the impact that solid-phase microextraction (SPME) and comprehensive multidimensional gas chromatography (GC×GC) is having on food analysis.
