Non-targeted Cross-Sample Analysis with Comprehensive Two-Dimensional Gas Chromatography (GC×GC)
Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.
The goal of non-targeted cross-sample analysis is to discover salient chemical characteristics from multiple samples. Applications of non-targeted cross-sample analysis include sample classification, quality control, chemical fingerprinting and biomarker discovery. Non-targeted cross-sample analysis should distinguish and reliably characterize all chemical constituents in each sample, correctly match the corresponding features that characterize each constituent in different samples, and recognize the most significant characteristics or patterns between or among samples. Comprehensive two‑dimensional gas chromatography (GC×GC) is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis. GC×GC data is information-rich but is also large and complex, making the analytical tasks of extracting and matching features and then recognizing salient patterns challenging. This review surveys some of the varied approaches that researchers have applied to these difficult problems.
RAFA 2024 Highlights: Contemporary Food Contamination Analysis Using Chromatography
November 18th 2024A series of lectures focusing on emerging analytical techniques used to analyse food contamination took place on Wednesday 6 November 2024 at RAFA 2024 in Prague, Czech Republic. The session included new approaches for analysing per- and polyfluoroalkyl substances (PFAS), polychlorinated alkanes (PCAS), Mineral Oil Hydrocarbons (MOH), and short- and medium-chain chlorinated paraffins (SCCPs and MCCPs).
Advancing Bladder Cancer Research with Mass Spectrometry: A FeMS Interview with Marta Relvas-Santos
November 12th 2024LCGC International interviewed FeMS Empowerment Award winner Marta Relvas-Santos on her use of mass spectrometry to identify potential biomarkers and therapies for bladder cancer. She also shared insights on her work with FeMS and advice for fellow scientists.
Pharmaceutical excipients, such as polyethylene glycol-based polymers, must be tested for the presence of ethylene oxide (EtO) and 1,4-dioxane as part of a safety assessment, according to USP Chapter <228>.
