Oliver J. Schmitz

This article explores the integration of high-resolution ion mobility spectrometry–mass spectrometry (HRIMS-MS) with liquid chromatography (LC) and quadrupole time-of-flight mass spectrometry (QTOF-MS) as a comprehensive workflow for PFAS analysis.

At Analytica this year, an oral session titled “A Dream Comes True: Fantastic News from Analytical Chemistry” focused on cutting-edge techniques in separation science in Hall 5 of the International Congress Center Munich (ICM) International Congress Center Munich (ICM).

Lipids in SFC are mainly separated according to their lipid classes, which simplifies quantification with standards. In this study, SFC coupled with drift time IM‑QTOF-MS was used to characterize the HepG2 lipidome.

In Chinese herbal medicine (CHM), traditionally, Hedyotis diffusa and Scutellaria barbata are cooked together and given to patients as tea. It is hypothesized that the interaction of metabolites from both herbs during cooking, improves the medical effect. This hypothesis was tested by preparing two tea variants which were then analyzed using high performance liquid chromatography (HPLC) coupled to ion-mobility mass spectrometry (IM-MS).

Invented by J. Phillips in 1989, comprehensive GCXGC has strong chromatographic resolving power; from its original petrochemical applications it has been extended to many others. However, coelutions with matrix peaks are often observed and a higher separation power is required.