Mass Spectrometry

Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.

Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.

LCGC International sat down with Jeff Zonderman, senior vice president of Bruker Applied MS at Analytica, to discuss sustainability, PFAS analysis, and the company’s year-old mass spectrometry division.

The serum/plasma estradiol is useful for diagnosis, pathology, and therapeutic efficacy monitoring of estrogen-dependent diseases, according to the authors.

Scientists from Anhui University of Chinese Medicine in Hefei, China recently investigated the mechanisms behind what makes huachansu tablets, a type of traditional Chinese medicine (TCM), effective against liver cancer.

On the occasion of Earth Day, University of Wisconsin-Madison graduate student and chemist Katelyn Michael speaks with LCGC about the methods she has been using to attempt to degrade known PFAS.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from the Netherlands created a new LC–MS/MS assay to test new small molecular inhibitors (SMIs) and their effectiveness in prognosing lung cancer.

In this edition of "Inside the Laboratory," John A. McLean, the dean of graduate education and research at the College of Arts & Science of Vanderbilt University, discusses his laboratory's recent work regarding ion mobility-mass spectrometry (IM-MS) and how it can be applied in various fields.

LCGC International sat down with Katarina Marakova to discuss her group’s work in top-down analysis of proteins using capillary zone electrophoresis–mass spectrometry (CZE–MS).

In this interview from Analytica 2024 in Munich, Germany, Michael Lämmerhofer of the University of Tuebingen discusses the potential of chiral stationary phases (CSPs) in different applications.

Experts from academia and industry present on the innovative research projects they are working on.

Here are the top five articles that the editors of LCGC International published this week.

Chromatographic and spectroscopic techniques alike were reviewed for their current effectiveness and future potential in this lecture session at Analytica 2024.

At Analytica 2024, four speakers tackled the issue of water quality and how the detection of what is contained therein continues to evolve.

Researchers from the Massachusetts Institute of Technology (MIT) used three-dimensional printing to develop new electrospray emitters to improve medical diagnostics.

Scientists at the Analytica conference in Munich, Germany, spoke about clinical mass spectrometry and its use in metabolomics and lipidomics.

This article describes newly introduced high-performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products in 2023–2024. It summarizes their technical specifications and significant user benefits.

Rabi Ann Musah, PhD, a professor of chemistry at the University of Albany, State University of New York, is exploring ways to help protect seed viability through optimizing the isolation of specific compounds. We sat down with her to discuss her research and findings.

Yuefei Ruan from the City University of Hong Kong, China, discusses the relevance of target analysis, extractable organofluorine analysis, high-resolution mass spectrometry (HRMS) screening, and the oxidative conversion of precursors for the analysis of PFAS in aquatic environments.

Here are the top five articles that the editors of LCGC International published this week.

Researchers at Enveda Biosciences are transforming nature into new medicines with their artificial intelligence (AI)-enabled industrial-scale drug discovery platform incorporating tandem mass spectrometry (MS/MS).

Adopted 35 years ago, the Montreal Protocol is an international treaty designed to protect the ozone layer. It addresses ozone depletion caused by industrial chemicals and remains a landmark environmental agreement in the phasing out and ban of the production and consumption of ozone-depleting substances (ODSs).

The 26th Norwegian Symposium on Chromatography was held 21–23 January 2024. The symposium has strong traditions in the Norwegian separation science community, serving as a forum for excellent scientific talks, networking, and social events.

A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.

A recent study out of Auburn University sought to further understand biological mechanisms at the molecular level using ion mobility spectrometry (IMS).

Element Materials Technology introduced its Rapid Response Pharmaceutical Testing Service, providing expedited testing and focusing on various requirements including active ingredients and final drug products, extractables and leachables, degradation production, and elemental impurities.

A study has proposed targeted methods, developed using gas chromatography coupled to tandem mass spectrometry, to measure human plasma protein binding and hepatocyte clearance in 73 per- and polyfluoroalkyl substances, or PFAS.

Microextraction using sustainable green solvents, followed by mass spectrometric analysis, comprise a combined approach that is still in its infancy.

Joycelyn Tan, a PhD candidate at the University of Cambridge, is the 2024 recipient of the Darlene Solomon Award, co-sponsored by Females in Mass Spectrometry and Agilent Technologies, and created to provide support for up-and-coming women scientists.