Mass Spectrometry

This article describes newly introduced high-performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products in 2023–2024. It summarizes their technical specifications and significant user benefits.

Rabi Ann Musah, PhD, a professor of chemistry at the University of Albany, State University of New York, is exploring ways to help protect seed viability through optimizing the isolation of specific compounds. We sat down with her to discuss her research and findings.

Yuefei Ruan from the City University of Hong Kong, China, discusses the relevance of target analysis, extractable organofluorine analysis, high-resolution mass spectrometry (HRMS) screening, and the oxidative conversion of precursors for the analysis of PFAS in aquatic environments.

Here are the top five articles that the editors of LCGC International published this week.

This month we interview David Steiner, head of product development at LVA GmbH–Lebensmittelversuchsanstalt in Klosterneuburg, Austria about his work developing liquid chromatography–tandem mass spectrometry (LC–MS/MS) multiclass methods for classification of feedstuff, including replication of model complex feedstuffs in the analytical laboratory.

Researchers at Enveda Biosciences are transforming nature into new medicines with their artificial intelligence (AI)-enabled industrial-scale drug discovery platform incorporating tandem mass spectrometry (MS/MS).

Adopted 35 years ago, the Montreal Protocol is an international treaty designed to protect the ozone layer. It addresses ozone depletion caused by industrial chemicals and remains a landmark environmental agreement in the phasing out and ban of the production and consumption of ozone-depleting substances (ODSs).

The 26th Norwegian Symposium on Chromatography was held 21–23 January 2024. The symposium has strong traditions in the Norwegian separation science community, serving as a forum for excellent scientific talks, networking, and social events.

A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.

A recent study out of Auburn University sought to further understand biological mechanisms at the molecular level using ion mobility spectrometry (IMS).

Element Materials Technology introduced its Rapid Response Pharmaceutical Testing Service, providing expedited testing and focusing on various requirements including active ingredients and final drug products, extractables and leachables, degradation production, and elemental impurities.

A study has proposed targeted methods, developed using gas chromatography coupled to tandem mass spectrometry, to measure human plasma protein binding and hepatocyte clearance in 73 per- and polyfluoroalkyl substances, or PFAS.

Microextraction using sustainable green solvents, followed by mass spectrometric analysis, comprise a combined approach that is still in its infancy.

Joycelyn Tan, a PhD candidate at the University of Cambridge, is the 2024 recipient of the Darlene Solomon Award, co-sponsored by Females in Mass Spectrometry and Agilent Technologies, and created to provide support for up-and-coming women scientists.

A recent review article highlights the current analytical techniques being used to detect illicit drug use in sports.

At the 2024 Pittcon Conference, Elizabeth Humston-Fulmer of LECO Corporation presented an improved workflow which uses two-dimensional gas chromatography (GCxGC) with dual time of flight (TOF) MS/FID detection. Shortly after Pittcon, Humston-Fulmer discussed this analytical method with us.

Scientists recently tested a new system for detecting and extracting favipiravir from plasma samples.

Conventional sample preparation can be time- and resource-consuming, and a green analytical methodology can be a game-changer for scientists, in addition to facilitating selective and sensitive separations.

A recent article examines how the coupling of liquid or gas chromatography to mass spectrometry has advanced the development dielectric barrier discharge ion sources.

Scientists from the Affiliated Hospital of Putian University recently analyzed the dysregulation of lipid metabolism in patients suffering from chronic hepatitis B patients.

Joycelyn Tan of the University of Cambridge recently won the Darlene Solomon Award for her notable research into mass spectrometry.

The company’s new service will provide expedited testing to customer around the world.

This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!

A recent study examined using high performance liquid chromatography coupled to mass spectrometry (HPLC–MS/MS) to optimize this key class of drugs that are used for the treatment of the common cold and flu.

In this review article, we showcase some of LCGC International’s recent coverage of mass spectrometry.

In a recent study from the GITAM School of Pharmacy, two scientists used different liquid chromatography techniques to assess the properties of ozenoxacin (OXC) and its degradation products.

Scientists investigated using this method to measure volatile organic compounds in the breath of patients with chronic kidney disease.

A multidisciplinary study was conducted to increase our understanding of thiosuccinimide linkers in bioconjugates.

In a recent study, researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College used liquid chromatography–mass spectrometry (LC–MS) to gain further insight into tumor metabolism.

In a recent study out of Central South University in Changsha, China, scientists tested different cosine similarity algorithms to test for illegal adulterants in drugs.