Mass Spectrometry

Webinar Date/Time: Tue, Feb 13, 2024 11:00 AM EST

In our second edition of “Inside the Laboratory,” Zhibo Yang, PhD, an associate professor of chemistry at the University of Oklahoma, discusses his group’s most recent work in single-cell mass spectrometry (MS) and MS tissue imaging.

LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.

Non-alcoholic beers are becoming more popular and need to reflect the sophisticated flavourings of beers that are brewed containing alcohol. Sophisticated analytical techniques can help to achieve this.

Rolduc 2024 takes place from 28–30 April 2024 in Rolduc Abbey, Kerkrade, The Netherlands.

Scientists in Xi’an, China have created a novel system for the analysis of cell membranes, based around haloalkane dehalogenase protein tag (HALO)-tag technology. Their research was published in Talanta.

The International School on Mass Spectrometry (IntSMS) returns in 2024, and it will take place on September 9–14th at the Ettore Majorana Foundation and Centre for Scientific Culture (EMFCSC) in Erice, Italy.

Webinar Date/Time: Thu, Feb 8, 2024 11:00 AM EST

In this LCGC Blog, the author explores stationary phases that incorporate permanent or induced charges within, or alongside, hydrophobic alkyl silica type bonded ligands.

Scientists from Washington and Connecticut have created a new system to detect epithelial ovarian cancer (EOC).

Researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College categorize the cardioprotective effects and other characteristics of flavonoids from the species commonly known as Chinese rosewood.

To detect certain pesticides in rice, wheat, and maize, scientists recently developed a new SFC-MS/MS technique.

Metabolite characterization can be complex. In this study, researchers at Yeungnam University used feature-based molecular networking (FBMN) to further understand glutathione (GSH) adducts.

This review article discusses scientific rationales and current best practices in the pharmaceutical industry for performing chromatographic peak purity assessments (PPA). These activities are associated with the development and validation of liquid chromatographic (LC) stability-indicating analytical methods applicable to regulatory submissions of small-molecule drug candidates. The discussion includes a comprehensive overview of the PPA-related regulatory and scientific landscape and common industry approaches to obtain PPA results, as well as the strengths and weaknesses of PDA-facilitated ultraviolet (UV) PPA and other PPA techniques.

A variety of chromatographic techniques have been used to quantify the full range of acyl-CoAs, formed when a fatty acid bonds with coenzyme A, but added complexity and analysis time adversely affect the level of throughput.

A group of scientists tested a new means of analyzing lipids in brain tissue using mass spectrometry imaging (MSI).

Scientists from the Huazhong University of Science and Technology have developed a new method for analyzing quinolones in urine.

The Chromatographic Society will honor five scientists and academics next year, conferring its highest honor, the Martin Medal, to David McCalley and Fabrice Gritti.

The hyphenated method was combined with a gradient ultracentrifugation technique that allowed for lipoprotein fraction separations.

While lipid oxidation in food is a serious problem, lipid species in both oxidized and non-oxidized forms at varying concentrations make detection and identification of the less abundant species difficult.

You're invited to publicize your 2023–2024 new product introductions in LCGC. Here's how to get your products included.

Yuefei Ruan from the City University of Hong Kong discusses her team’s research on the importance of monitoring PFAS in aquatic environments.

Scientists from Fudan University in Shanghai, China created a system for reducing retention-time variations in metabolomic analysis using ultrahigh-performance liquid-chromatography coupled with mass spectrometry (UPLC-MS).

A group of scientists from Xi’an, China have created a new system for analyzing cell membranes based around HALO-tag technology.

Scientists from Essen, Germany recently created a method for simultaneously analyzing fatty acids (FAs) and fatty acid methyl esters (FAMEs).

A recent study published in the Journal of Separation Science reveals how ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) could be used to detect and quantify purine metabolites.

Innovative native separation strategies coupled with native mass spectrometry techniques to characterize biopharmaceuticals close to their natural state are described.

A novel method to simultaneously characterize the capping and poly(A) tail for therapeutic mRNA in a single sample preparation workflow is described.

An interview with Reed Harris on critical quality attributes and other contemporary trends in biopharm analysis.

A novel LC–MS/MS method, with a dual ESI and APCI source using simple solvent extraction for sample preparation, was validated for analysis of 102 pesticides and 5 mycotoxins regulated by Colorado state in dried hemp.