October 25th 2024
Here is some of the most popular content posted on LCGC International this week.
Rapid Quantitative Analysis of Ethylene Oxide and 1,4-Dioxane in Polymeric Excipients Using SIFT-MS
Pharmaceutical excipients, such as polyethylene glycol-based polymers, must be tested for the presence of ethylene oxide (EtO) and 1,4-dioxane as part of a safety assessment, according to USP Chapter <228>.
Self-Cleaning LC–MS in Organoid/Organ-on-Chip Systems for Small Molecule Analysis
August 7th 2024Steven Ray Wilson and Hanne Røberg-Larsen of the University of Oslo recently discussed the practical application and advantages of their FDA-validated research to analyse small molecule drugs and their metabolites in organoid/organ-on-chip systems that serve as alternatives to animal models.
GC–MS to Determine Polycyclic Aromatic Hydrocarbons in Acai Foods
August 2nd 2024University of Campinas and Iowa State University scientists recently combined vacuum-assisted sorbent extraction (VASE) and gas chromatography-mass spectrometry (GC–MS) to determine polycyclic aromatic hydrocarbons in açaí-based food products.
Characterization of Product Related Variants in Therapeutic Monoclonal Antibodies
July 16th 2024Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.
Next Generation Peak Fitting for Separations
July 9th 2024Separation scientists frequently encounter critical pairs that are difficult to separate in a complex mixture. To save time and expensive solvents, an effective alternative to conventional screening protocols or mathematical peak width reduction is called iterative curve fitting.