Best of the Week: HTC-18 Workshops, ASMS Preview, Investigating Chocolate
This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!
ASMS 2024: An Interview with Elizabeth Neumann of the University of California, Davis
Aaron Acevedo
Elizabeth Neumann is an Assistant Professor in the Department of Chemistry at the University of California, Davis. She has been a NIH Postdoctoral Fellow at Vanderbilt University, a NSF Doctoral Fellow at University of Illinois at Urbana-Champaign, and she has earned a BS in Chemistry from Baylor University. Recently, LCGC International sat down with Neumann to discuss her presentation, "Multi-Site Reproducibility Trial of MALDI-IHC Multiplexed Targeted Protein Imaging using a 33-Organ Tissue Microarray."
Multidimensional Liquid Chromatography Covered at HTC 2024
Aaron Acevedo
During the 18th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, held May 28–31, 2024 in Leuven, Belgium, a workshop session titled “Multidimensional Liquid Chromatography” was held on May 30. Led by Session Chair Oliver J. Schmitz of the University Duisburg-Essen in Germany, this session focused on the various ways multidimensional liquid chromatography (LC) can be used in different applications. Topics ranged from cannabis analysis to cholesterol biosynthesis, with speakers including André de Villiers of Stellenbosch University in South Africa and Pia Wittenhofer of the University Duisburg-Essen in Germany.
Investigating Glyoxal and Methylglyoxal Formation and Bioaccessibility in Chocolate with HPLC
John Chasse
α-dicarbonyl compounds (α-DCs) are formed from carbohydrates via the heating and storage process, mainly through the Maillard reaction (MR; the nonenzymic browning reaction of reducing sugars with amines and typically involves amino acids, proteins, and peptides), caramelization, lipid-peroxidation, and enzymatic reaction. Recently, a new study focused on evaluating the formation of α-DCs in chocolates under replicated digestive system conditions. The concentrations of glyoxal and methylglyoxal in chocolates before and after the process were concluded using through high-performance liquid chromatography (HPLC) analysis.
Emerging Industrial Applications in MS Covered at HTC 2024
Aaron Acevedo
On May 28, experts presented on emerging industrial applications during the International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, in Leuven, Belgium. Led by Session Chair Peter Van Broeck of Johnson & Johnson in Belgium, this session was dedicated to sharing what mass spectrometry (MS) and other analytical chemistry techniques can do on a practical level in various fields. Topics range from the advancements made in mass spectrometry (MS)-based structure identification to using selected-ion flow tube mass spectrometry (SIFT-MS) to monitor industrially relevant volatile organic compounds (VOCs) in air. Speakers include Filip Cuyckens of Johnson & Johnson in Belgium and Hannes Lüdtke of the German Aerospace Center.
Analyzing Total Phenolic Content in Vegetable Oils Using a Smartphone
John Chasse
Traditional methods of analyzing total phenolic content (TPC) include ultraviolet/visible (UV-vis) spectrophotometry, high-performance liquid chromatography (HPLC), and gas chromatography (GC). These approaches require sophisticated equipment as well as a stable laboratory environment, and, while they are effective, there are cost restraints, specialized knowledge is needed to use them, and their stationary nature makes them less ideal for measurements onsite or in the field. In a recent study published in the journal Foods, Sanita Vucane and her colleagues at the Latvia University of Life Sciences and Technologies (Jelgava, Latvia) created a new technique for discovering the total phenolic content (TPC) in vegetable oils through analysis of images captured by a cellphone.
Critical Role of Oligonucleotides in Drug Development Highlighted at EAS Session
November 19th 2024A Monday session at the Eastern Analytical Symposium, sponsored by the Chinese American Chromatography Association, explored key challenges and solutions for achieving more sensitive oligonucleotide analysis.
Analytical Challenges in Measuring Migration from Food Contact Materials
November 2nd 2015Food contact materials contain low molecular weight additives and processing aids which can migrate into foods leading to trace levels of contamination. Food safety is ensured through regulations, comprising compositional controls and migration limits, which present a significant analytical challenge to the food industry to ensure compliance and demonstrate due diligence. Of the various analytical approaches, LC-MS/MS has proved to be an essential tool in monitoring migration of target compounds into foods, and more sophisticated approaches such as LC-high resolution MS (Orbitrap) are being increasingly used for untargeted analysis to monitor non-intentionally added substances. This podcast will provide an overview to this area, illustrated with various applications showing current approaches being employed.
RAFA 2024 Highlights: Contemporary Food Contamination Analysis Using Chromatography
November 18th 2024A series of lectures focusing on emerging analytical techniques used to analyse food contamination took place on Wednesday 6 November 2024 at RAFA 2024 in Prague, Czech Republic. The session included new approaches for analysing per- and polyfluoroalkyl substances (PFAS), polychlorinated alkanes (PCAS), Mineral Oil Hydrocarbons (MOH), and short- and medium-chain chlorinated paraffins (SCCPs and MCCPs).
