LC–MS

Scientists in Xi’an, China have created a novel system for the analysis of cell membranes, based around haloalkane dehalogenase protein tag (HALO)-tag technology. Their research was published in Talanta.

In our first edition of “Inside the Laboratory,” Laura-Isobel McCall, PhD, an associate professor of chemistry at San Diego State University, discusses her group’s most recent work using “chemical cartography” in order to perform effective liquid chromatography–mass spectrometry (LC–MS) data acquisition.

Researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College categorize the cardioprotective effects and other characteristics of flavonoids from the species commonly known as Chinese rosewood.

A variety of chromatographic techniques have been used to quantify the full range of acyl-CoAs, formed when a fatty acid bonds with coenzyme A, but added complexity and analysis time adversely affect the level of throughput.

The hyphenated method was combined with a gradient ultracentrifugation technique that allowed for lipoprotein fraction separations.

Webinar Date/Time: Tue, Jan 23, 2024 11:00 AM CET (5:00 AM EST)

Scientists from Fudan University in Shanghai, China created a system for reducing retention-time variations in metabolomic analysis using ultrahigh-performance liquid-chromatography coupled with mass spectrometry (UPLC-MS).

As 2023 comes to an end, we laid out the most read articles of the past year.

A group of scientists from Xi’an, China have created a new system for analyzing cell membranes based around HALO-tag technology.

A novel method to simultaneously characterize the capping and poly(A) tail for therapeutic mRNA in a single sample preparation workflow is described.

A novel LC–MS/MS method, with a dual ESI and APCI source using simple solvent extraction for sample preparation, was validated for analysis of 102 pesticides and 5 mycotoxins regulated by Colorado state in dried hemp.

Scientists from South Dakota State University and the University of Colorado School of Medicine created a system to detect traces of cyanide in blood samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS).

A recent study conducted in Beijing, China, presented a novel method involving LC–MS/MS, UAE, and online SPE for characterizing environmental pollutants.

A new study proposed a method for the determination of antibiotics and eight different metabolites, utilizing techniques like ultrasound-assisted extraction and LC–MS/MS.

Agilent Technologies presents this award to industry leaders as a means of supporting them through financial aid, products, and expertise, along with recognition.

Webinar Date/Time: Thursday, December 14th, 2023 at 8am PST | 11am EST | 4pm GMT | 5pm CET

Researchers used metabolomics analysis to measure different harvest times during the whole growing period of ligustri lucidi fructus (LLF), a traditional Chinese medicinal herb.

To combat fraudulent sales of low-aged ginseng disguised as high-aged ginseng, scientists from Shanghai University of Traditional Chinese Medicine created machine learning models to predict the ages of ginseng samples.

Scientists from Zhejiang, China recently conducted experiments meant to properly characterize sucrose ester isomers from tobacco samples.

Troubleshooting continues to evolve constantly, changing how we overcome issues such as chemical causes of peak tailing.

We present formulation and delivery of gene therapy products, focusing on adeno-associated virus (AAV) formulations. We also discuss the analytical technologies most used to characterize these products.

Among the chlorinated byproducts of water disinfection within the fresh-cut industry, haloacetic acids (HAAs) are known to pose a consumer health risk if they remain present in the treated product.

The α-glucosidase inhibitors (AGIs) were isolated from extracts of Agrimonia pilosa Ledeb (APL), which is a perennial herb used in traditional Chinese medicine (TCM).

Webinar Date/Time: Tue, Nov 7, 2023 11:00 AM EST

A novel lenvatinib stability-indicating method, developed through a quality by design (QbD) approach and embracing principles of green chemistry, offers a robust solution for ensuring the drug's stability under various conditions.

Researchers have developed a meticulous method for analyzing impurities in a product used for early treatment of breast cancer in premenopausal and perimenopausal women, shedding light on the product’s degradation pathways.

Three different metrics were used experimentally, based on measurements of both NIST Standard Reference Material (SRM) 1950 and data obtained from murine kidney tissue.

Webinar Date/Time: Tuesday, November 14th, 2023 at 8am PST | 11am EST | 4pm GMT | 5pm CET

Webinar Date/Time: Wed, Nov 8, 2023 11:00 AM EST

Valérie Pichon's review in Analytical and Bioanalytical Chemistry delves into sophisticated liquid chromatography techniques for detecting albumin adducts, vital biomarkers in retrospective mustard agent exposure monitoring, offering a broader window of detection than urine-based methods.