March 27th 2025
David Megson from Manchester Metropolitan University in Manchester, UK, spoke to LCGC International about the latest developments in non-targeted analysis (NTA) of per- and polyfluoroalkyl substances (PFAS) in environmental matrices based on a recent systematic review paper he has collaboratively published (1).
Light Scattering and Viscometry: the Winning Combination for GPC/SEC Polymer Analysis
November 10th 2022Airing 1: Thursday November 10, 2022 at 9am EST Airing 2: Thursday November 10, 2022 at 2pm EST Polymer characterization is key to understanding their properties and ensuring the quality of final products containing polymers. Discover why light scattering and viscometry in size-exclusion chromatography become the new gold standard in polymer analysis.
What’s Your Workflow? Non-Targeted Analysis of Water Samples
September 1st 2022Are generic workflows really needed in environmental analysis? In the end, it is the analyst— not instrumentation or software—that is in charge of what data are obtained, after thoughtfully considering what sample preparation and acquisition method to use.
The Origin and Implications of Artifact Ions in Bioanalytical LC–MS
July 1st 2022Although well known, the extent of adduct ion formation in LC–ESI-MS/MS, and the implications for quantitative analysis and analyte characterization are not fully appreciated. We explore this problem and explain the implications for reproducibility, quantitative and qualitative analyses, and DDA and DIA.
Deployable Mass Spectrometry for Rapid On-Site Bioanalysis
July 1st 2022With the advent of ambient ionization and portable mass spectrometers, the ability to perform rapid, on-site analysis is fast becoming a reality. We review the critical recent developments enabling this capability as well as remaining challenges that must be tackled to enable widespread adoption.
Taking the Red Pill: Alleviating Matrix Effects for Small Molecule Quantitation in Food and Feed
May 1st 2022Rudolf Krska and Michael Sulyok from the University of Natural Resources and Life Science in Vienna, Austria, discuss their recent work developing a multi‑analyte approach using liquid chromatography tandem mass spectrometry (LC–MS/MS), and the issues surrounding agrocontaminants in animal feeds.
The 2022 Winners of the Lifetime Achievement and Emerging Leader in Chromatography Awards
February 1st 2022Barry L. Karger and James P. Grinias are the winners of the 15th annual LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, respectively, for 2022. Here, we review their achievements.
Detecting Environmental PFAS Using Liquid Chromatography–Tandem Mass Spectrometry
January 21st 2022The presence of per- and polyfluoroalkyl substances (PFAS) in products used every day by millions of people is a cause of concern among both consumers and scientists. PFAS found in drinking water and the environment can cause serious health issues in animals and humans. Amanda Belunis, who is a PhD candidate at the University of Maryland in Baltimore County, has been investigating the use of liquid chromatography–tandem mass spectrometry (LC–MS/MS) to detect PFAS from a variety of environmental sources. She spoke with us about methods used to detect PFAS and described a new method that she and her team have developed to enhance PFAS detection.
Intact Mass Analysis of Biopharmaceuticals as its Own Unique Application
November 1st 2021Intact mass analysis is becoming increasingly useful for characterizing biologics. We describe the current application of intact mass analysis, including quantitation, sequencing, and structural characterization.