MilliporeSigma

This article will discuss several aspects of working with high purity water in LC-MS analyses including quality and handling. Solutions will be proposed for optimal water purification based on the use of complementary purification technologies combined with application-specific final filtering, and finally, the importance of water purification system maintenance will be discussed.

This article will discuss several aspects of working with high purity water in LC-MS analyses including quality and handling. Solutions will be proposed for optimal water purification based on the use of complementary purification technologies combined with application-specific final filtering, and finally, the importance of water purification system maintenance will be discussed.

This application note demonstrates the use of Thermal Desorption as a greener approach for sampling of terpenes in the air for workplace exposure or terpene profiling

Quantitative measurement of biotherapeutic and clinically important biomarker proteins using LC-MS/MS has seen great development in the last 15 years. Stable Isotope Labelled Internal Standards are a cornerstone of accurate quantitation and there are several options ranging from signature peptides to “winged” longer peptides or full 13C and/or 15N labelled proteins to choose from. In this video Kevin Ray, Kwasi Mawunyega and Anders Fridstrom will discuss pros and cons with different SIL IS approaches as well as similarities and differences between biopharmaceutical bioanalysis and biomarkers for disease research & diagnosis.

Webinar Date/Time: Tuesday, November 29th, 2022 at 11am EST|8am PST|4pm GMT|5pm CET

Webinar Date/Time: Fri, Dec 2, 2022 11:00 AM EST

Wednesday, November 9th, 2022 at 10am EST|7am PST|3pm GMT|4pm CET Chromatographic approaches to intact and middle-up analysis of monoclonal antibodies delving into detailed, more complex strategies for analysis, including ADCs.

Thu, Sep 8, 2022 11:00 AM EDT Tips for Improved Peptide Mapping: Navigating Past Pitfalls to Achieve New Peaks of Success" by Cory E. Muraco, MilliporeSigma's Biomolecules Workflow Product Manager. Improve your LC-MS peptide mapping skills by learning how column chemistry and optimized sample preparation methods can lead to higher accuracy and throughput.

MilliporeSigma experts will be sharing their experience in providing tips for protein biologics sample preparation. Special focus is on reduction and deglycosylation for characterizing antibody-drug conjugates, as well as enzyme and chemical treatment options to ensure desired results when deglycosylating glycoprotein samples.

Three MilliporeSigma experts sharing their personal experiences in a cordial roundtable discussion counting down 5 tips to incorporate into your pharma analysis & QC validation strategy.

Monday, September 20, 2021 at 11am EDT | 8am PDT| 4pm BST | 5pm CEST Learn how system-related PFAS contamination might hamper your LC–MS analysis and discover solutions to overcome this issue.

***Live Dates:Day 1, Wednesday, November 18, 2020 9am–11:30am EST | 2pm – 3:30pm GMT | 3pm-4:30pm CET Day 2, Thursday, November 19, 2020 9am–11:30am EST | 2pm – 3:30pm GMT | 3pm-4:30pm CET ***Biopharmaceutical analysis is a fast-paced and constantly evolving field, and chromatographers play a pivotal role. This two-day virtual event, focusing on cutting-edge trends, has been organized by The Chromatographic Society (“ChromSoc”) in collaboration with LCGC and features talks from top analytical chemists working in biopharmaceutical analysis.***On demand available after final airing until Nov. 19, 2021***

For effective analytical practices, it is important to understand and control the binding of analytes to filters and pre-filters. This summary discusses the effect of sample filtration on analyte binding.

Are you using sample preparation techniques effectively in your HPLC and GC methods? Are you aware of the latest advances in sample preparation? Join us for this informative web seminar to learn more about how to use sample preparation effectively and the latest advances in sample preparation techniques. The panelists can answer your questions too! Part 1: Thursday, Sept. 17, 2020 at 10am EDT| 2pm BST| 3pm CEST Part 2: Friday, Sept. 18, 2020 at 10am EDT| 2pm BST| 3pm CEST On demand available after final airing until Sept. 18, 2021.

How can you easily improve sensitivity of your LC–MS setup? Discover this and more in the upcoming webcast. Live: Tuesday, Mar. 17, 2020 at 11am EDT | 8am PDT | 3pm GMT | 4pm CET On demand available after final airing Mar. 17, 2021 Register free

How can you easily improve sensitivity of your LC–MS setup? Discover this and more in the upcoming webcast. Live: Thursday, Jan. 30, 2020 at 11am EST | 8am PST | 4pm GMT | 5pm CET On demand available after final airing Jan. 30, 2021 Register free

In this webcast, Dr. Estelle Riche will discuss how water is purified for the most sensitive analytical techniques, will provide guidance on how to select the optimal water purification solution, and will give tips on preventing water contamination for optimal experimental results. Live: Tuesday, Dec. 3, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET On demand available after final airing Dec. 3, 2020 Register free

Potency testing in marijuana-infused edibles is a problematic task due to the complexity of the matrices. The concentration of active ingredients in edibles can range from a few ppm to 3.5% (1). In this application, active cannabinoid compounds were extracted from gummy bears (and also brownies, results not shown), followed by HPLC analysis.