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Proceeds from Pittcon 2016 are distributed by its sponsoring societies, the Society for Analytical Chemists of Pittsburgh (SACP), and the Spectroscopy Society of Pittsburgh (SSP).

Appropriate analytical methods are required to evaluate the presence, metabolism, degradation, and removal of specific compounds in complex mixtures. There is an increasing demand to analyze samples with a wide range of polarities in a variety of applications, including environmental analysis, biomarker discovery, and proteomics. Multiple analyses on complementary columns are often needed to cover the separation of all compounds with a large difference in polarity. This article describes a generic method involving an ultrahigh‑pressure liquid chromatography (UHPLC) system equipped with two external switching valves to connect hydrophilic interaction liquid chromatography (HILIC) and reversed-phase LC columns in series for the sequential analysis of polar and apolar compounds.

Understanding how liquid chromatography pumps operate can help streamline solving pump problems.

Nontargeted metabolite profiling by ultrahigh-pressure liquid chromatography–mass spectrometry (UHPLC–MS) is a powerful technique to investigate the influence of genetic and environmental factors on metabolic phenotypes in plants. The approach offers an unbiased and in-depth analysis that can reveal molecular markers of desirable phenotypic traits that can be complementary to genetic markers in plant breeding efforts. Here, the power of nontargeted metabolite profiling is illustrated in a study focused on the determination of molecular markers in malting barley that are predictive of desirable malting quality for brewing applications.

Leon Blumberg has been at the cutting edge of chromatography since the late 1980s. The Column spoke with him about his contribution to the past, present, and future of chromatography.

Not every method is as we would hope it would be. Some methods come to us in imperfect form and we have to live with them, while others are difficult separations and, by necessity, need to be developed using close control of several variables such as eluent pH, eluotropic strength, ionic strength etc.

The 27th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2016) will be held in Guangzhou, China, from 13–16 November 2016.

A preview of the upcoming 31st International Symposium on Chromatography (ISC 2016), which is due to be held 28 August–1 September at University College Cork, Ireland.

This is the final instalment in a series of four articles exploring topics that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June 2016.

Thermo Fisher Scientific has extended a technology collaboration with the University of Birmingham in the UK. Thermo Fisher will supply a range of mass spectrometry instruments to be used at the University’s new Phenome Centre.

Waters Corporation has announced the addition of Richard Chang and Xiao Ran Yu to its Asia Pacific leadership team. Chang has been appointed as Vice President of Waters’ Asia Pacific Operations and Yu has been appointed as General Manager of Waters China.

Food and beverage manufacturers who perform simple sugar analysis require methods that provide sensitive, selective, and direct determination of carbohydrates. Minimizing errors associated with sample preparation is of key importance, because samples often require large dilutions that can impact the downstream accuracy of results. In this summary, the benefits of using high-performance anion-exchange chromatography coupled with pulsed amperometric detection (HPAE-PAD), which does not require sample derivatization, will be discussed. We will also cover recent technological advances, including high pressure ion chromatography, which have enabled manufacturers to analyze more samples in less time.

Leap Technologies Inc. and Antec have announced a joint venture in the field of sample preparation for HDX–MS.

Click the title above to open The Column June 06, 2016 Europe & Asia issue, Volume 12, Number 10, in an interactive PDF format.

Click the title above to open The Column June 06, 2016 North American issue, Volume 12, Number 10, in an interactive PDF format.

While conventional calibration for gel permeation (GPC) or size-exclusion chromatography (SEC) is useful, there are inherent disadvantages in this type of analysis that introduce experimental error. This uncertainty may cast serious aspersions on the rigour and utility of the results. Multi-angle light scattering (MALS) detection is quite simple to add to an existing chromatography system and can help overcome the challenges faced with single detector chromatography and conventional calibration-based methods. An alternative separation technique called asymmetric flow field-flow fractionation (AF4) offers tunable, column-free fractionation.

J.J. Kirkland and J.J. DeStefano spoke to LCGC about the important contributions Dr. Klaus Unger has made to chromatography as Dr. Unger celebrates his 80th birthday.

How to optimize the key variables in GC analysis – sample introduction

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Different techniques of liquid chromatography (LC) mobile-phase mixing can give different results and have different problems.

In the world of data integrity, the focus is typically on the data and the numbers. How can technology, such as a laboratory information management system (LIMS), help to ensure data integrity?

The third instalment in this series provides an overview of modern practices of separation science in small-molecule drug development. It highlights approaches in high performance liquid chromatography (HPLC) method development and physical or chemical characterization to support process chemistry and formulation development, and for assessment or control of clinical trial materials. The roles of separation scientists in analytical development and salient chromatographic methodology trends are also discussed.

The 18th International Symposium on Advances in Extraction Technologies (ExTech’2016) and the 22nd International Symposium on Separation Sciences (ISSS’2016) will be held at the Cultural and Congress Centre “Jordanki”, Torunˊ, Poland, from 3–6 July 2016.

Click the title above to open the LCGC Asia Pacific June 2016 regular issue, Vol 19, No 2, in an interactive PDF format.

Click the title above to open the LCGC Europe June 2016 regular issue, Vol 29, No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2016 regular issue, Vol 34 No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2016 regular issue, Vol 34 No 6, in an interactive PDF format.

Following a successful launch last year, Shimadzu’s Lab4You program is once again accepting applications from young and enthusiastic researchers hoping to advance their research.