Chromatography Fundamentals, Part VI: The Gaussian Distribution and Moment Analysis
April 1st 2019How well do Gaussian-shaped profiles represent injected solute peaks after they are eluted through a chromatographic column? This question is explored along with a discussion of moment analysis for determining retention time, variance, and shapes of peaks.
Advancing Chromatographic Analysis Using Selective and Robust Sample Preparation
April 1st 2019The field of sample preparation is undergoing revolutionary change, largely governed by the need for miniaturization while maintaining high selectivity and high analyte enrichment. How up-to-date are you in the advances of sample preparation for chromatographic analysis?
Nanomaterials Have Come to Stay: An Overview of their Use as Sorbents in Sample Preparation
A simple, fully-automated method is proposed to analyze extractables and leachables-compounds that are released from packing materials into drugs during storage-using SPME-GC×GC–MS. This method avoids the use of sample preparation solvents and reduces sample handling, and is ideal for routine use in quality control.
A simple, automated, and fast method to quantify complex odorants in foods is described using stir-bar sorptive extraction (SBSE) combined with fast enantioselective GC–MS analysis. The total analytical method takes only 30 minutes and does not require any sample pretreatment.
New HPLC Systems and Related Products Introduced in 2018–2019: A Brief Review
April 1st 2019This instalment describes high performance liquid chromatography (HPLC), mass spectrometry (MS), and related products introduced at Pittcon 2019 and during the year prior. It reviews new HPLC and MS systems, modules, chromatography data systems (CDS), and other related software and summarizes their significant features and user benefits. A brief description of instrumentation trends and the current market is also included.
Affinity Selection-Mass Spectrometry: Development and Application in Drug Discovery (Symposium)
March 21st 2019This symposium, organized by Hui Zhang and Chang Liu, will be held in Room 120A from 8:30 to 11:45 am and covers the topic of affinity selection by mass spectrometry (ASMS), an attractive alternative for drug discovery.