The LCGC Blog: If at First You Don’t Succeed—Where Next in HPLC Method Development!
January 15th 2019You may be one of the many analytical scientists who look with envy at those laboratories who are equipped with sophisticated automated HPLC method development systems. These systems are indeed very nice and can be very efficient in narrowing down choices, however, they aren’t a universal panacea and one can achieve a lot with a simple, paired down approach.
YMC Acquires Pharmaceutical Systems Business of Lewa-Nikkiso America
January 7th 2019YMC Co., Ltd. (Kyoto, Japan), a supplier of separations resins, services, and systems for the pharmaceutical market, has acquired the pharmaceutical systems business of Lewa -Nikkiso America Inc. (Devens, Massachusetts).
Stopping GC and GC–MS Problems Before They Start
January 1st 2019The best troubleshooting is proactive; problems are much more easily prevented then solved. Proactive troubleshooting involves anticipating problems before they start, and stopping them before they disrupt your workflow. It also ensures a long operational lifetime for instruments. Unlike many other instruments, a gas chromatograph (GC) has several components, each of which must be properly maintained and optimized for the full instrument to operate properly. This instalment of “GC Connections” focuses on simple proactive steps that users of a gas chromatograph can take to ensure that instruments will operate correctly over time.
Data Integrity and USP : Part 3: Monitoring and Requalification
January 1st 2019This is the final part of a trilogy looking at the impact of the new USP on analytical instrument qualification (AIQ) on data integrity in a regulated chromatography laboratory. This part will focus on the performance qualification (PQ) portion of the 4Qs model and, specifically, monitoring and requalification of chromatographs.
Is Headspace Sampling Quantitative?
January 1st 2019Confusion exists on the quantitative nature of headspace sampling, because it is an equilibrium-based technique when done in the static mode, but not necessarily in the dynamic mode. To aggravate matters further, the concentrations of headspace compounds in common applications, like foods, flavours, or petroleum distillates, can easily vary by an order of magnitude or more. Thus, what defines quantitative may depend largely on the goals of the analysis. This month we’ll take a look at headspace sampling and its quantitative nature.
The 52nd Annual Conference of the German Society for Mass Spectrometry (DGMS 2019)
January 1st 2019The 52nd Annual Conference of the German Society for Mass Spectrometry (DGMS 2019) will be held 10–13 March 2019, together with the Spring Meeting of the German Physics Society (DPG). This double conference will be hosted by the University of Rostock as a main event in its 600-year anniversary celebrations.
Methods and Purposes for Determining Higher Order Structures of Biopharmaceuticals
January 1st 2019Determining the higher order structure of a protein pharmaceutical is important. Here, we review the approaches for HOS determination that are currently receiving the most attention in the literature and at scientific meetings.
Drawing A Better Map: Recent Advances in Protein Digestion and Peptide Mapping
December 17th 2018Biotherapeutics have become the hottest topic in pharmaceutical research over the past decade. With the increased interest in biotherapeutics, there has been a concomitant increase in new analytical methods for characterizing these large, complex molecules. This installment of “Column Watch” discusses advances in “bottom-up” analysis of monoclonal antibodies, while highlighting the role and importance column chemistry still plays in developing highly selective high-performance liquid chromatography (HPLC) methods for peptides.