Dorton Analytical has been appointed the UK agency rights to support and supply the Dynamic Extraction range of high performance countercurrent chromatography (HPCCC) instrumentation.
Dorton Analytical has been appointed the UK agency rights to support and supply the Dynamic Extraction range of high performance countercurrent chromatography (HPCCC) instrumentation.
According to the company, today's business environment demands that all scientists involved in the development process use their time more effectively and HPCCC instruments offer an alternative in the purification of synthetic molecules (small and large), peptides, natural product and petrochemical applications.
Scale-up on these instruments is reported to be simple, reliable and robust, compared with HPLC; where the company claims scale up can sometimes require complicated processes involving redevelopment of chromatography methods.
Due to the benefit of easy scale-up, the company reports HPCCC instruments are becoming a popular choice for liquid chromatography applications in pharmaceutical discovery and development, natural products and petrochemicals.
To find out more visit www.dortonanalytical.co.uk
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.