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Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Latest:
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Latest:
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Latest:
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Latest:
The SFC Renaissance?Jean-Luc Veuthey and Alexandre Grand-Guillaume-Perrenoud reveal the latest developments in supercritical fluid chromatography (SFC) that are bringing the technique back to the limelight.
Latest:
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Latest:
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Latest:
Analysis of Nicotine Alkaloids and Impurities in Liquids for e-Cigarettes by LC–MS, GC–MS, and ICP-MSThe development of various analytical MS methods to investigate the chemical composition of liquids used in electronic cigarettes and characterize their quality is presented in this study.
Latest:
Analysis of Nicotine Alkaloids and Impurities in Liquids for e-Cigarettes by LC–MS, GC–MS, and ICP-MSThe development of various analytical MS methods to investigate the chemical composition of liquids used in electronic cigarettes and characterize their quality is presented in this study.
Latest:
Analysis of Nicotine Alkaloids and Impurities in Liquids for e-Cigarettes by LC–MS, GC–MS, and ICP-MSThe development of various analytical MS methods to investigate the chemical composition of liquids used in electronic cigarettes and characterize their quality is presented in this study.
Latest:
Analysis of Nicotine Alkaloids and Impurities in Liquids for e-Cigarettes by LC–MS, GC–MS, and ICP-MSThe development of various analytical MS methods to investigate the chemical composition of liquids used in electronic cigarettes and characterize their quality is presented in this study.
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Lab-on-a-Chip GC for Environmental ResearchThe development of a microfabricated comprehensive GC that can be used as a portable measurement device.
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2D-LC–MS for the Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates in a Regulated EnvironmentHigh-resolution mass spectrometry (MS) is not readily compatible with chromatographic techniques using high-salt mobile phases. This study presents the development and use of 2D-LC–MS via an on-line desalting step for the analysis of monoclonal antibodies and antibody–drug conjugates.
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Rapid Quantification of Trypsin Inhibitors in Food and Feed Formulations with Electrospray Ionization Mass SpectrometryMeasuring trypsin inhibitors in legumes is important to feed processors, who are concerned with providing high-quality products for animal feed. In this study, a rapid, accurate, and precise method for the quantification of trypsin inhibitor activity is evaluated.
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Troubleshooting LC Separations of Biomolecules, Part 2: Passivation and Mobile-Phase AdditivesBioinert and biocompatible liquid chromatography (LC) systems are becoming more commonplace in laboratories, but the majority of biomolecule separations still use LC systems composed primarily of stainless steel parts. Can passivation or mobile phase additives improve separations on these systems for metal-sensitive biomolecules?
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Multi-Attribute Monitoring of Therapeutic mRNA by Liquid Chromatography–Mass SpectrometryA novel method to simultaneously characterize the capping and poly(A) tail for therapeutic mRNA in a single sample preparation workflow is described.
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Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass SpectrometryAmong all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function.
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2D-LC–MS for the Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates in a Regulated EnvironmentHigh-resolution mass spectrometry (MS) is not readily compatible with chromatographic techniques using high-salt mobile phases. This study presents the development and use of 2D-LC–MS via an on-line desalting step for the analysis of monoclonal antibodies and antibody–drug conjugates.
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LC/MS Screening for EDTA in Fresh Blood Swabs Using an Expression CMS SystemExplore the potential for screening human blood fortified with ethylenediaminetetraacetic acid (EDTA) via LC/MS using an expression single quadrupole compact mass spectrometer.
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LC/MS Screening for EDTA in Fresh Blood Swabs Using an Expression CMS SystemExplore the potential for screening human blood fortified with ethylenediaminetetraacetic acid (EDTA) via LC/MS using an expression single quadrupole compact mass spectrometer.
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Fast Sample Preparation with Liquid Chromatography Tandem Mass Spectrometry for Illegal Opioid AnalysisWith the growing use of illegal opioids, analysts should be prepared for a large influx of samples in their laboratories. While the workload may be increasing, the number of analysts and equipment may not, so the need for faster and better liquid chromatography–mass spectrometry (LC–MS) methods is important. By implementing an efficient sample preparation technique for matrix cleanup for some of the most common and traditional opioid matrices-blood and urine-coupled with a rapid and accurate LC method, laboratories can address the analytical needs for this growing problem.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Generic UHPLC Method for the Simultaneous Analysis of Compounds with a Wide Range of PolaritiesAppropriate analytical methods are required to evaluate the presence, metabolism, degradation, and removal of specific compounds in complex mixtures. There is an increasing demand to analyze samples with a wide range of polarities in a variety of applications, including environmental analysis, biomarker discovery, and proteomics. Multiple analyses on complementary columns are often needed to cover the separation of all compounds with a large difference in polarity. This article describes a generic method involving an ultrahigh-pressure liquid chromatography (UHPLC) system equipped with two external switching valves to connect hydrophilic interaction liquid chromatography (HILIC) and reversed-phase LC columns in series for the sequential analysis of polar and apolar compounds. The method was successfully applied to separate 32 pharmaceutical compounds with a wide range of polarities, which could be useful for analyzing pharmaceutical compounds in the environment.
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Magnetic Nanoparticles for Solid-Phase ExtractionMagnetic nanoparticles (m-NPs) are becoming important in analytical chemistry as sorbents in dispersive solid-phase extraction (d-SPE) because they simplify the extraction process and save time as a result of their isolation from the sample matrix by an external magnetic field. Many synthetic processes have been developed to fabricate these nanomaterials and an additional coating step is usually included at the end of the synthesis to improve their stability and to avoid the formation of agglomerates. A wide variety of coatings have been used for this purpose to improve selectivity. This manuscript provides an overview of the different synthesis methods, coatings, and applications of m-NPs as sorbents in d-SPE.
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Magnetic Nanoparticles for Solid-Phase ExtractionMagnetic nanoparticles (m-NPs) are becoming important in analytical chemistry as sorbents in dispersive solid-phase extraction (d-SPE) because they simplify the extraction process and save time as a result of their isolation from the sample matrix by an external magnetic field. Many synthetic processes have been developed to fabricate these nanomaterials and an additional coating step is usually included at the end of the synthesis to improve their stability and to avoid the formation of agglomerates. A wide variety of coatings have been used for this purpose to improve selectivity. This manuscript provides an overview of the different synthesis methods, coatings, and applications of m-NPs as sorbents in d-SPE.
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Nanomaterials Have Come to Stay: An Overview of their Use as Sorbents in Sample PreparationThis article reviews how nanomaterials are being used in a variety of sample preparation techniques, such as dispersive solid-phase extraction (dSPE), solid-phase microextraction (SPME), stir-bar sorptive extraction (SBSE), and matrix solid-phase dispersion (MSPD).
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Contemporary Analysis of Chiral MoleculesThe first high performance liquid chromatography (HPLC) column for enantioselective chromatography was introduced commercially in 1981. This chromatographic mode has now become the method of choice for the analysis of chiral pharmaceutical compounds, making previous approaches, such as optical rotation, almost completely obsolete. However, supercritical fluid chromatography (SFC) has been gaining increasing recognition as a complementary technique to HPLC for pharmaceutical enantioselective analysis. Gas chromatography (GC) and capillary electrophoresis (CE) remain very useful for particular applications.
