Author
Latest:
Analysis of Weak UV-Absorbing Pharmaceutical Drug Substances Using CE with Condensation Nucleation Light-Scattering DetectionThe authors descibe the use of CE with condensation nucleation light-scattering detection to analyze three pharmaceutical analytes. Because the compounds lack adequate UV chromophores, they require a more sensitive means of detection.
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Preparation and Characterization of a Pyrethrum Extract StandardThe authors describe how they separated and collected milligram quantities of six pyrethrin esters in pyrethrum extract and used them to create analytical reference standards for these insecticide compounds.
Latest:
Analysis of Weak UV-Absorbing Pharmaceutical Drug Substances Using CE with Condensation Nucleation Light-Scattering DetectionThe authors descibe the use of CE with condensation nucleation light-scattering detection to analyze three pharmaceutical analytes. Because the compounds lack adequate UV chromophores, they require a more sensitive means of detection.
Latest:
Analysis of Weak UV-Absorbing Pharmaceutical Drug Substances Using CE with Condensation Nucleation Light-Scattering DetectionThe authors descibe the use of CE with condensation nucleation light-scattering detection to analyze three pharmaceutical analytes. Because the compounds lack adequate UV chromophores, they require a more sensitive means of detection.
Latest:
Analysis of Weak UV-Absorbing Pharmaceutical Drug Substances Using CE with Condensation Nucleation Light-Scattering DetectionThe authors descibe the use of CE with condensation nucleation light-scattering detection to analyze three pharmaceutical analytes. Because the compounds lack adequate UV chromophores, they require a more sensitive means of detection.
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The Story of Thin-Layer ChromatographyThis installment surveys the evolution of thin-layer chromatography...
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Buffers and BaselinesThis month's "LC Troubleshooting" focuses on the baseline characteristics of several common LC buffers and methods to minimize drift.
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Ultrahigh-Efficiency Protein Separations with Submicrometer Silica Using Slip FlowProfessor Mary Wirth and graduate students Bingchuan Wei and Benjamin Rogers from Purdue University demonstrate a quantum leap in protein column efficiency. Using colloidal silica particles of submicrometer diameters (470 nm), they obtained plate heights that were as much as 15-fold lower than the theoretical limit for Hagen-Poiseuille flow.
Latest:
Ultrahigh-Efficiency Protein Separations with Submicrometer Silica Using Slip FlowProfessor Mary Wirth and graduate students Bingchuan Wei and Benjamin Rogers from Purdue University demonstrate a quantum leap in protein column efficiency. Using colloidal silica particles of submicrometer diameters (470 nm), they obtained plate heights that were as much as 15-fold lower than the theoretical limit for Hagen-Poiseuille flow.
Latest:
Selective Sorbents for Solid-Phase Extraction Based on Molecularly Imprinted PolymersHighly selective sorbents for solid-phase extraction (SPE) are desirable tools for the development of selective and sensitive methods for trace analysis. Molecular imprinting is an emerging technique that can yield analyte- or group-selective polymeric sorbents.
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Advances in Amino Acid AnalysisThe authors review current strategies for amino acid analysis and explain their novel approach for simplified sample preparation of body fluids for amino acid analysis...
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Advances in Amino Acid AnalysisThe authors review current strategies for amino acid analysis and explain their novel approach for simplified sample preparation of body fluids for amino acid analysis...
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Detecting Mushroom Peptide Toxins in Body Fluids by Capillary ElectrophoresisThe Death Cap mushroom is the cause of most mushroom-related poisonings in the world. The author has developed a highly efficient, sensitive CE technique that toxicologists and forensic analysts can use to determine the poisonous peptides in body fluids of affected patients.
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Capillary Electrophoresis as a Routine Analytical Tool in Pharmaceutical AnalysisThis "CE Currents" column examines the use of capillary electrophoresis (CE) in three important areas of pharmaceutical analysis.
Latest:
Capillary Electrophoresis as a Routine Analytical Tool in Pharmaceutical AnalysisThis "CE Currents" column examines the use of capillary electrophoresis (CE) in three important areas of pharmaceutical analysis.
Latest:
Selective Sorbents for Solid-Phase Extraction Based on Molecularly Imprinted PolymersHighly selective sorbents for solid-phase extraction (SPE) are desirable tools for the development of selective and sensitive methods for trace analysis. Molecular imprinting is an emerging technique that can yield analyte- or group-selective polymeric sorbents.
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Striving to Validate NutraceuticalsGuest authors Thompson and Morris summarize the problems and progress in establishing regulated analytical methods for dietary supplements.
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Striving to Validate NutraceuticalsGuest authors Thompson and Morris summarize the problems and progress in establishing regulated analytical methods for dietary supplements.
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New Developments in the Application of Monolithic HPLC ColumnsThe guest authors discuss the use of monolithic silica columns in high-throughput HPLC, including developments and applications in combinatorial chemistry. They also explain performance characteristics for these columns and provide caveats about their effective usage.
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New Developments in the Application of Monolithic HPLC ColumnsThe guest authors discuss the use of monolithic silica columns in high-throughput HPLC, including developments and applications in combinatorial chemistry. They also explain performance characteristics for these columns and provide caveats about their effective usage.
Latest:
New Developments in the Application of Monolithic HPLC ColumnsThe guest authors discuss the use of monolithic silica columns in high-throughput HPLC, including developments and applications in combinatorial chemistry. They also explain performance characteristics for these columns and provide caveats about their effective usage.
Latest:
New Developments in the Application of Monolithic HPLC ColumnsThe guest authors discuss the use of monolithic silica columns in high-throughput HPLC, including developments and applications in combinatorial chemistry. They also explain performance characteristics for these columns and provide caveats about their effective usage.
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Analytica 2018 Event PreviewAnalytica will take place from 10–13 April 2018 at the Messe München, in Munich, Germany. The Analytica conference is Analytica’s scientific highlight and will take place at the International Congress Center (ICM) from 10–12 April 2018. The increasing digitization in the laboratory and the handling of the resulting flood of data are big focus this year. This preview will shed more light on what to expect.
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Why All C18 SPE Phases Are Not EqualOctadecyl bonded silica gel (C18) is widely used in solid-phase extraction (SPE), but there are many variations including particle size, pore size, surface chemistry, and carbon loading applications.
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Volumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole BloodWhole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were carried out using volumetric absorptive microsampling (VAMS), a novel blood collection device that allows the sampling of a known blood volume independently from hematocrit. The composition of the extraction medium was optimized using an experimental design to get the most intense signal of hepcidin, considering different organic solvents and acidic additives.
Latest:
Volumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole BloodWhole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were carried out using volumetric absorptive microsampling (VAMS), a novel blood collection device that allows the sampling of a known blood volume independently from hematocrit. The composition of the extraction medium was optimized using an experimental design to get the most intense signal of hepcidin, considering different organic solvents and acidic additives.
Latest:
Volumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole BloodWhole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were carried out using volumetric absorptive microsampling (VAMS), a novel blood collection device that allows the sampling of a known blood volume independently from hematocrit. The composition of the extraction medium was optimized using an experimental design to get the most intense signal of hepcidin, considering different organic solvents and acidic additives.
Latest:
Volumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole BloodWhole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were carried out using volumetric absorptive microsampling (VAMS), a novel blood collection device that allows the sampling of a known blood volume independently from hematocrit. The composition of the extraction medium was optimized using an experimental design to get the most intense signal of hepcidin, considering different organic solvents and acidic additives.
Latest:
Volumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole BloodWhole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were carried out using volumetric absorptive microsampling (VAMS), a novel blood collection device that allows the sampling of a known blood volume independently from hematocrit. The composition of the extraction medium was optimized using an experimental design to get the most intense signal of hepcidin, considering different organic solvents and acidic additives.
Latest:
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical AnalysesA newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
