Biopharmaceuticals and Protein Analysis

University of Campinas and Iowa State University scientists recently combined vacuum-assisted sorbent extraction (VASE) and gas chromatography-mass spectrometry (GC–MS) to determine polycyclic aromatic hydrocarbons in açaí-based food products.

Dalian Maritime University scientists recently used high-performance liquid chromatography tandem triple quadrupole mass spectrometry HPLC-MS/MS to help detect amphetamine-type drugs in water.

Scientists from Università Politecnica delle Marche reported on baseline separation of isotopologoues of some amphetamine (AMP) derivatives on achiral and polysaccharide-based chiral columns.

Here are the top five articles published on LCGC International this week.

Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.

Shaanxi University of Technology scientists recently used analytical techniques including gas chromatography to identify various volatile organic compounds (VOCs) in different types of Chinese bacon.

Scientists from the Zheijiang University of Technology published a review article on the extraction of terpenoids from essential oils to determine what techniques can optimize enantiomer separation.

This article describes a comprehensive study on optimizing ion-pair reversed-phase liquid chromatography for analysing protected and unprotected single-stranded DNA oligonucleotides.

This article explores three case studies where autosampler injection programs help to (i) reduce the carry-over observed for large nucleic acids during anion-exchange chromatography (AEX), (ii) reduce peak distortion and breakthrough for monoclonal antibodies (mAbs) during hydrophilic-interaction chromatography (HILIC), and (iii) facilitate dissolution of lipid nanoparticles (LNPs) so that a size-exclusion chromatography (SEC) method can be applied for ribonucleic acid (RNA) payload analysis.

In biotherapeutics manufacturing, controlling size variants of therapeutic monoclonal antibodies (mAbs) is critical for ensuring product quality.

Scientists from Naif Arab University recently used a new approach to protect amide-based synthetic cannabinoids from degradation and esterification during GC–MS analysis.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from the University of Geneva in Geneva, Switzerland and AstraZeneca in Mölndal analyzed how HILIC is related to the connections between oligonucleotide structures and diastereomer separation.

University of Tübingen scientists recently tested a new approach to hydrophilic-interaction chromatography (HILIC) to address retention time repeatability issues.

Scientists from Roche Diagnostics in Germany are testing a new liquid chromatography (LC)-based approach for advancing process analytical technology (PAT) in biopharmaceutical processing.

The editors of BioPharm International spoke with Christine Rozanas, PhD, global product marketing manager at Cytiva, to discuss the advantages and persistent challenges with implementing continuous downstream chromatography.

Scientists from the University of Isfahan in Iran recently developed a new system for detecting and quantifying B vitamins in human samples.

Scientists from Hebei Medical University developed a sensitive liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for analyzing free fatty acids in human serum.

Scientists from the University of Edinburgh evaluated different polishing chromatography elution strategies to optimize output.

LCGC International sat down with Kemi Osho of the University of Nevada, Reno (UNR) to discuss her career and work with the Females in Mass Spectrometry (FeMS) group.

A session at the HTC-18 conference in Belgium featured speakers from around the world detailing the latest advances in biopharmaceutical analysis.

Here are the top five articles that the editors of LCGC International published this week.

During the 18th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, experts presented a workshop on different ways multidimensional liquid chromatography can be applied.

In preparation for ASMS 2024, we sat down with Elizabeth Neumann of the University of California, Davis about her upcoming workshop.

A recent paper discusses advances in hydrophilic interaction chromatography (HILIC) in the analysis of therapeutic oligonucleotides and their impurities.

Scientists from Changchun University of Chinese Medicine used UHPLC-Q-Orbitrap-MS/MS analysis to identify the active compounds in TongFu XieXia Decoction for treating intestinal obstruction.

Scientists from the Lunan Pharmaceutical Group explored the use of UHPLC-MS/MS to test the effects of Shouhui Tongbian capsules (SHTBs) on slow transit constipation (STC).

Scientists from Manipal Academy of Higher Education in India recently discussed different protein profile pattern analysis techniques and how they can help allow for universal screening.

Scientists from Vanderbilt University recently tested a new means of imaging mass spectrometry (IMS) for isotopically resolved intact proteins.

Scientists from Chongqing University Cancer Hospital recently developed a new system for analyzing the potential impact of retention time (RT) prediction on targeted LC–MS-based lipidomics.