U-GPC? Making GPC/SEC Faster
Can a UHPLC approach be easily transferred to speed up GPC/SEC measurements? Unfortunately, the answer is: No! But there are other solutions to make GPC/SEC faster
Ultra-HPLC (UHPLC) provides a new potential for method development and analysis. It is achieved by using a sub-2 µm particle size column packing at increased linear velocities. The advantage of UHPLC over conventional HPLC is the reduced analysis time without sacrificing efficiency. In comparison to traditional HPLC, analysis time can be decreased up to a factor of 7–10.
So the question for GPC/SEC users is: Can this approach be easily transferred to speed up GPC/SEC measurements? Unfortunately, the answer is: No - the UHPLC approach does not work! But there are other solutions to make GPC/SEC faster!
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
