Author


Derek Stevenson

Latest:

ChromSoc Activities: The Reid International Bioanalytical Forum

The Reid International Bioanalytical Forum is a conference geared towards bioanalytical scientists. It has a unique philosophy where challenging data is often presented to an audience who are encouraged to engage. This article describes how the meeting series was initiated and developed over the past 40 years and how this philosophy has been embedded into the meeting.




Kai Zhang

Latest:

Important Considerations Regarding Matrix Effects When Developing Reliable Analytical Residue Methods Using Mass Spectrometry

Practical examples of how to correct for matrix effects in food testing to obtain reliable quantitative data using LC–MS and GC–MS


Brian Mosley

Latest:

Development of a Stability Indicating Method for Green Fluorescent Protein by HPLC

This article describes the development of a HPLC method for the assay of green fluorescent protein (GFPuv) in-process samples from our model therapeutic protein production process. Specificity of the method is evaluated by demonstrating a suitable HPLC method to separate and detect closely related protein degradation species.


Nathaniel Hentz

Latest:

Development of a Stability Indicating Method for Green Fluorescent Protein by HPLC

This article describes the development of a HPLC method for the assay of green fluorescent protein (GFPuv) in-process samples from our model therapeutic protein production process. Specificity of the method is evaluated by demonstrating a suitable HPLC method to separate and detect closely related protein degradation species.


Laura McGregor

Latest:

GC/GC–MS

A snapshot of key trends and developments in the GC/GC–MS sector according to selected panelists from companies exhibiting at Analytica 2018.


Jan Knoop

Latest:

Determination of Contaminants in Beer Using LC–MS/MS and ICP-MS

The German Beer Purity Law of 1516 makes beer one of the best analyzed food products with the highest standards regarding quality, freshness, appearance, and flavor. According to this law, beer is allowed to contain hops, malt, yeast, and water as ingredients. Of course, beer also contains major B vitamins, bitter substances, and minerals and trace elements (such as Ca, Na, Mg, and Zn) that are important for human nutrition. However, undesirable substances such as pesticides and heavy metals (for instance Cd, Pb, Hg, Sb, and As) can be found as well, mostly as contaminants in brewing water and grains. In particular, the herbicide glyphosate has to be monitored carefully since it is discussed as a possible carcinogenic. The chromatography of glyphosate is challenging because of its high polarity. A well-established method including a derivatization step with 9-fluorenylmethyl chloroformate (FMOC) followed by LC–MS analysis is time-consuming and also susceptible to errors. A sample pretreatment without derivatization is desirable because it is faster and cheaper. A triple quadrupole mass spectrometer optimizes the analytical procedure and establishes a routine method for the analysis of glyphosate in beer. For the determination of low element concentrations, such as As, Se, Pb, Cd, and Zn, inductively coupled plasma-mass spectrometry (ICP-MS) is applied.


Karen Rome

Latest:

ChromSoc Activities: Academic Support

A look at some of the opportunities ChromSoc currently offers.




Kolby Jardine

Latest:

Measuring Carbon Tetrachloride Atmospheric Mixing Ratios in the Central Amazon Rainforest

Carbon tetrachloride (CCl4) is a potent greenhouse gas in the troposphere, while in the stratosphere it contributes to ozone destruction. Global atmospheric models treat anthropogenic industrial processes as the sole source of atmospheric CCl4. However, some evidence suggests that biogenic sources may also contribute. This article describes grab-sampling with analysis by thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS) to assess levels of CCl4 in a Central Amazonian rainforest. We find that ambient air mixing ratios within and above the forest, while agreeing with current equatorial estimates (120 ppt), show diurnal and canopy-height variations that suggest a biogenic source of CCl4, and therefore may be important for closing the gaps in the global atmospheric CCl4 budget.


Angela Jardine

Latest:

Measuring Carbon Tetrachloride Atmospheric Mixing Ratios in the Central Amazon Rainforest

Carbon tetrachloride (CCl4) is a potent greenhouse gas in the troposphere, while in the stratosphere it contributes to ozone destruction. Global atmospheric models treat anthropogenic industrial processes as the sole source of atmospheric CCl4. However, some evidence suggests that biogenic sources may also contribute. This article describes grab-sampling with analysis by thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS) to assess levels of CCl4 in a Central Amazonian rainforest. We find that ambient air mixing ratios within and above the forest, while agreeing with current equatorial estimates (120 ppt), show diurnal and canopy-height variations that suggest a biogenic source of CCl4, and therefore may be important for closing the gaps in the global atmospheric CCl4 budget.


Franz Schmitz

Latest:

Trace Perchlorate Determination by Ion Chromatography

Perchlorate salts are relatively stable, soluble in water, and migrate into groundwater sources causing possible challenges for drinking water suppliers as dissolved perchlorate has been identified to impair normal thyroid function. The development of a sensitive analytical method for perchlorate determination is therefore important to protect public health. This article addresses the validation of ion chromatography with suppressed conductivity detection (IC–CD), applying isocratic elution to analyze perchlorate.


Udo Neist

Latest:

Trace Perchlorate Determination by Ion Chromatography

Perchlorate salts are relatively stable, soluble in water, and migrate into groundwater sources causing possible challenges for drinking water suppliers as dissolved perchlorate has been identified to impair normal thyroid function. The development of a sensitive analytical method for perchlorate determination is therefore important to protect public health. This article addresses the validation of ion chromatography with suppressed conductivity detection (IC–CD), applying isocratic elution to analyze perchlorate.


Ursula K. Deister

Latest:

Trace Perchlorate Determination by Ion Chromatography

Perchlorate salts are relatively stable, soluble in water, and migrate into groundwater sources causing possible challenges for drinking water suppliers as dissolved perchlorate has been identified to impair normal thyroid function. The development of a sensitive analytical method for perchlorate determination is therefore important to protect public health. This article addresses the validation of ion chromatography with suppressed conductivity detection (IC–CD), applying isocratic elution to analyze perchlorate.


Maike A. Seiler

Latest:

Trace Perchlorate Determination by Ion Chromatography

Perchlorate salts are relatively stable, soluble in water, and migrate into groundwater sources causing possible challenges for drinking water suppliers as dissolved perchlorate has been identified to impair normal thyroid function. The development of a sensitive analytical method for perchlorate determination is therefore important to protect public health. This article addresses the validation of ion chromatography with suppressed conductivity detection (IC–CD), applying isocratic elution to analyze perchlorate.









Lourdes Ramos

Latest:

Sample Preparation: The State of the Art

In this extended special feature to celebrate the 30th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments. We asked key opinion leaders in the field to discuss the current state of the art in sample preparation.



Hernan Cortes

Latest:

Multidimensional Gas Chromatography using Planar Microfluidic Devices for the Characterization of Chlorinated Degreasers in Marine Gas Oil

A practical and reliable analytical procedure that incorporates MDGC with a planar microfl uidic device as a Deans switch was developed for the characterization of chlorinated degreasers in marine gas oil.


A. Talamona

Latest:

Isolation of Benzylideneacetophenone from a Crude Reaction Mixture

Benzylideneacetophenone forms the central core for a variety of important biological compounds, known collectively as chalcones. Many of these compounds have significant medicinal value as they demonstrate antibacterial, antifungal, antitumor, and anti-inflammatory properties.


Hannah Calder

Latest:

Detection of ODSs and HGSs in Industrial Zones Using a Cryogen-Free Preconcentration GC–MS Method

Adopted 35 years ago, the Montreal Protocol is an international treaty designed to protect the ozone layer. It addresses ozone depletion caused by industrial chemicals and remains a landmark environmental agreement in the phasing out and ban of the production and consumption of ozone-depleting substances (ODSs).


Ludivine Fromentoux

Latest:

Determination of Contaminants in Beer Using LC–MS/MS and ICP-MS

The German Beer Purity Law of 1516 makes beer one of the best analyzed food products with the highest standards regarding quality, freshness, appearance, and flavor. According to this law, beer is allowed to contain hops, malt, yeast, and water as ingredients. Of course, beer also contains major B vitamins, bitter substances, and minerals and trace elements (such as Ca, Na, Mg, and Zn) that are important for human nutrition. However, undesirable substances such as pesticides and heavy metals (for instance Cd, Pb, Hg, Sb, and As) can be found as well, mostly as contaminants in brewing water and grains. In particular, the herbicide glyphosate has to be monitored carefully since it is discussed as a possible carcinogenic. The chromatography of glyphosate is challenging because of its high polarity. A well-established method including a derivatization step with 9-fluorenylmethyl chloroformate (FMOC) followed by LC–MS analysis is time-consuming and also susceptible to errors. A sample pretreatment without derivatization is desirable because it is faster and cheaper. A triple quadrupole mass spectrometer optimizes the analytical procedure and establishes a routine method for the analysis of glyphosate in beer. For the determination of low element concentrations, such as As, Se, Pb, Cd, and Zn, inductively coupled plasma-mass spectrometry (ICP-MS) is applied.