Application Notes

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.

A fast and efficient SPE sorbent, Strata-X PRO, was chosen to extract a panel of acids, neutrals, and bases from plasma to reduce the number of steps in the clean-up.

This application focuses on developing a rapid SPE and LC-MS/MS method for the quantitative analysis of uracil and its two homologues from human serum.

In this application, an SPE method is implemented for a panel of pain relievers to produce acceptable results to offer an alternative solution for high recoveries and to reduce matrix effects.

Software solutions can guide all stages of pharmaceutical stress testing, from prediction of degradation chemistry to analytical development and, project management.

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

This application note describes the measurement of ionic content in drinking water using the new HIC-ESP Ion Chromatograph to determine and minimize potential health risks.

Synthetically derived food and beverage dye analysis to meet regulatory requirements aimed at reducing the risk of allergies, cancers, and attention deficits.

This application note describes the molecular weight determination of different polymer samples under micro-GPC conditions with up to 80% less solvent consumption.

This applicationnote describesthe molecular weight determination of different polymer samplesunder micro-GPC conditions with up to 80% less solvent consumption.

The timsTOF fleX system bridges a current gap by providing MALDI Imaging and in-depth proteomics analysis in just one instrument. The instrument offers all benefits of a timsTOF Pro for time-efficient and sensitive proteomics, combined with a high-resolution MALDI source and stage. Using PASEF technology, it is possible to retrieve high protein ID rates with small sample amounts. Here we present the new SpatialOMx® workflow to identify distinct proteomic profiles for different tumor subpopulations in breast cancer as an example for this powerful approach.

For effective analytical practices, it is important to understand and control the binding of analytes to filters and pre-filters. This summary discusses the effect of sample filtration on analyte binding.

Biogen and Postnova present data on the analysis of adeno-associated viruses (AAV) using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering detection (AF4-MALS). AAV are promising gene therapy delivery vehicles, whose efficacy may be negatively affected by the presence of viral aggregates. Due to its gentle separation and broad applicable size range, AF4-MALS is able to characterize AAV and their aggregates with high resolution and precision, thereby overcoming the drawbacks that column-based chromatography techniques often face when dealing with samples larger than 50 nm in size.

For effective analytical practices, it is important to understand and control the binding of analytes to filters and pre-filters. This summary discusses the effect of sample filtration on analyte binding.

This technical overview presents sample purification under low and high pH conditions via two columns on one system, with automated column and solvent switching.

This application describes the purification of paracetamol from crude sample in early-stage drug discovery. Outstanding purity (>99%) and recovery (>95%) are achieved.

This technical overview presents an entire purification workflow using a 1290 Infinity II Autoscale Preparative LC/MSD System with Automated Purification Software.

This technical overview describes how to increase fraction capacity by clustering multiple fraction collectors. Smart software helps keep track of the fractions.