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LC–MS compatible ADC analysis by reverse-phase
In this application YMC-Triart Bio C4 was used to analyse a reduced monoclonal antibody and a reduced ADC mimic with formic acid or TFA as additives.
Protect Your Lab Against COVID-19
Note discusses how labs can protect themselves against spreading COVID-19 among its employees.
Advanced Analytical Workflow Solutions for Monitoring Critical Quality Attributes of Monoclonal Antibodies
Recombinant mAbs tend to be unstable and susceptible to modification/degradation. These mAbs need to be identified/monitored for successful drug development. New advanced LC–MS workflows have been developed to meet such needs.
Two-Dimensional Purification for Complex Natural Products
This application note describes the isolation of target compounds from Rhodiola rosea using online mass-based 2D-LC purification to quickly achieve the highest purity.
Analysis of BTEX in Water Using Hydrogen Carrier Gas
This application note shows that hydrogen is a valuable alternative to helium, as it is lower in cost and provides great separation in shorter analysis time.
Advancements in Native Analysis by Microchip Capillary Electrophoresis-ESI-MS
Monitoring Amino Acid Composition of Cell Culture Media using Microfluidic CE-MS
Determination of Full, Partial and Empty Capsid Ratios for Adeno-Associated Virus (AAV) Analysis
Gene Therapy and Oligonucleotide Compendium
Genome Sizing Methodology for Genome Integrity Analysis of Adeno-Associated Viruses (AAV)
Purity Analysis of Adeno-Associated Virus (AAV) Capsid Proteins using CE-LIF Technology
Liquid Chromatography at Room Temperature: When Should the Column Temperature Be Specified in a Method?
In reversed-phase liquid chromatography, increasing the column temperature usually results in a decrease in analyte retention. Will this cause problems if a method does not call for control of the column temperature but the room temperature of the laboratory environment changes?
New Gas Chromatography Products for 2019–2020
“GC Connections” presents the column’s annual review of new developments in the field of gas chromatography seen at Pittcon and other venues in the past 12 months.
Guide to Advancing Biopharmaceutical Development from Research to Routine with Multi-Attribute Method (MAM)
More and more manufacturers are embracing multi-attribute method, which simplifies biopharmaceutical product quality testing, and facilitates the measurement and monitoring of critical quality attributes.
The Method Development Advantages Offered by Hybrid-Silica Products
Mycotoxin Detection in Cannabis Products
Isocratic HPLC method for the analysis of mycotoxins and aflatoxins uses the DFL-10 filter fluorescence detector with a photochemical reactor to improve sensitivity.
Essential Oil Characterization with GC–MS
By analyzing and characterizing a mint essential oil, we can demonstrate the benefits of full m/z range data, deconvolution, and retention index determinations.
Cell Protein Analysis Using Agilent AssayMAP Bravo
An HCP analysis workflow including the Agilent AssayMAP Bravo platform for automated sample preparation, 6545XT AdvanceBio LC/Q‑TOF for LC-MS/MS analysis
ROI and Productivity Increases with Ultivo
This whitepaper demonstrates the features and benefits of owning an Ultivo LC/TQ in terms of actual tangible benefits to your laboratory operations.
Determination of Nitrosamine Impurities Using Ultivo
A method describing the detection of 12 potentially mutagenic nitrosamine impurities found in sartan drugs using the Ultivo LC/TQ
Rapid Low-Level Identification and Quantification of Host Cell Proteins
HCPs can threaten drug product efficacy and stability. LC–MS/MS using automated sample prep can address HCP analysis challenges. Software and hardware workflow upgrades can optimize HCP analysis methods.
Phospholipid and Protein Removal in One SPE Process Prevents Matrix-Based Signal Suppression
Here, we used Resprep PLR SPE to simultaneously remove proteins and phospholipids from plasma in one high-efficiency sample preparation process.
Characterization of nano-pharmaceuticals with FFF-MALS-DLS
FFF-MALS-DLS provides the detailed characterization of nano-pharmaceuticals that is essential for development and regulatory filing.
Analysis of PFAS in Water by LC–MS/MS
Stay one step ahead of water regulation, QSight™ LC–MS/MS offers sensitivity, selectivity, and robustness while saving time on maintenance and cleaning operations for your testing.
Improve ROI with Integrated LC–MSD Solution
Use interactive calculators included in this whitepaper to determine the incremental economic value of the Agilent 1260 Infinity II Prime LC and InfinityLab LC/MSD iQ.
Characterization of TSKgel® FcR-IIIA-NPR™ HPLC Column by Top Down Mass Spectrometry
This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.
Achieving Up to 70% Faster GC PAH Analysis
The Zebron ZB-PAH-EU and ZB-PAH-SeleCT offer unparalleled performance of targeted selectivity for PAHs in food, environmental, electronics, and fuel industries.
Purgeable Volatile Organic Compounds by GC–MS Using Zebron™ ZB-624PLUS™ GC Columns
In this application, we look at purgeable volatile organic compounds by GC–MS using Zebron™ ZB-624PLUS™ GC columns.
Residual Solvents per USP 467 Using Zebron™ ZB-624PLUS™ and ZB-WAXPLUS™ GC Columns
In this application, we look at residual solvents per USP 467 using Zebron™ ZB-624PLUS™ and ZB-WAXPLUS™ GC columns.
The Fast FAME GC Column: Zebron ZB-FAME
How to reduce FAME run times by up to 75% and improve the separation of cis/trans FAME isomers while remaining compatible with AOAC, AOCS, and IOC regulatory methods.