Application Notes

This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.

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From siRNA to mRNA to DNA, separating full length product from impurities can be challenging. Taking into consideration the nature of the oligonucleotide you are interested in, you will be able to make informed choices about what approach to use to characterize or purify your molecule.

This application note describes the company’s range of oligonucleotide columns and oligonucleotide standards.

This application note demonstrates the suitability of the company’s stationary phases to separate deprotected RNA and DNA oligonucleotides of different sizes.

A method using the company’s system to purify long-and short-term oligonucleotides is described.

This application note demonstrates direct ion-pair reversed-phase online desalting using 2D -LC for the analysis of oligonucleotides.

Polymeric strong anion exchange methods such as PL SAX are suitable for anion exchange and purification of oligonucleotides. At elevated temperatures, enhanced mass transfer increases the resolution for larger oligonucleotides. Working at higher PH values enables resolution of phosphodiester and phosphothioate forms of the oligonucleotide.

IONICON PTR-TOF real-time breath gas analyzers are deployed for finding a quick, non-invasive test to identify a SARS-CoV-2 infection in exhaled breath.

Key bourbon odorants with flavor dilution factor 201 found by solventless extraction and GC–MS/O-Aroma Dilution Analysis. Data analysis and AEDA-like reporting is shown.

GC/MS system capabilities can be expanded using versatile technology. A new multi-mode pyrolyzer addresses analytical challenges and increases efficiency.

Released & 2AB labelled N-glycans of similar structure, are shown to be well separated using HILIC methodology with the Avantor® ACE® Glycan column. 

In this publication, the concentrations of various amino acids in a culture fluid under different culture conditions were monitored using the Hitachi LA-8080 amino acid analyser.

Efficient and reproducible separation of thymidine oligomers is achieved using an ion-pair reversed phase shallow gradient method with the Avantor® ACE® Oligo column.

To analyse fatty acids, they are derivatised to FAME’s for analysis by GC.  Here we separate 22 FAMEs with two CLA isomers using the Avantor® Hichrom HI-10 phase.

In this white paper we discuss the importance of correct mobile phase buffer selection and pH control in LC and LC–MS method development.