Smiths Detection is part of the global business Smiths Group, a leading developer and manufacturer of advanced technology solutions for civil and military markets worldwide.
Smiths Detection is part of the global business Smiths Group, a leading developer and manufacturer of advanced technology solutions for civil and military markets worldwide. Smiths Detection scientific division develops instruments for real world lab applications where rapid and accurate answers are a requirement, not an option.
We use a range of advanced technologies that include microscopy, Fourier transform infrared (FT-IR) spectroscopy, ion mobility spectrometry (IMS), and Raman spectroscopy to help provide users with the most easy-to-use, accurate and definitive tools available.
Our innovative, user-focused solutions are helping to change the pace of chromatography. It is a cutting-edge technology that is fast and environmentally practical, offering alternatives to HPLC.
LCGC continues to serve as an invaluable tool in which we use to better understand the needs of our customers, reach them and help us build new relationships. LCGC lets us puts our message in front of more leaders, trend-setters, advanced chromatographers as well as those just learning. It is more than a trade publication, or an online forum, it is a marketplace that drives communication, advancements, and improvements along the way.
In their 25th year, LCGC is a leading resource and a trusted source of information. Congratulations.
Mike McCreary
Mike McCreary
Vice President, Scientific Division
Smiths Detection
Determining Neurotransmitters in Spinal Cords with UHPLC
February 18th 2025Researchers at Jilin University (Changchun, China) developed a highly sensitive, rapid, and accurate method for analyzing neurotransmitters (NTs) in rat spinal cord tissue. Ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS) in conjunction with ultra-ionic liquid dispersive liquid-liquid microextraction (UA-MIL-DLLME) were used to extract NTs for analysis.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
Revolutionizing LC-MS with Next-Gen Separation for Cyclic Peptide Analysis
February 17th 2025Cyclic peptides, known for their stability and high specificity, are promising therapeutic agents in the fight against cancer, infections, and autoimmune diseases. However, developing effective cyclic peptides presents numerous challenges, including poor pharmacokinetics, efficacy, and toxicity. Traditional methods like liquid chromatography tandem-mass spectrometry (LC-MS/MS) often struggle with resolving isomeric linear peptide metabolites, posing significant risks in safety, efficacy, and regulatory approval. In this paper, Komal Kedia, PhD, will share how she leveraged MOBIE’s high-resolution ion mobility-mass spectrometry (IM-MS) system to achieve a 72% reduction in run times, 200% greater resolving power, and enhanced accuracy in identifying “soft spots” prone to enzymatic degradation.